公开(公告)号：US20130197594A1

公开(公告)日：2013-08-01

申请号：US13798684

申请日：2013-03-13

申请人： Aaron R. McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

发明人： Aaron R. McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36053 ,  A61N1/3606 ,  A61N1/36128 ,  A61N1/36139

摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

公开(公告)号：US08406876B2

公开(公告)日：2013-03-26

申请号：US12688575

申请日：2010-01-15

申请人： Aaron R. McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

发明人： Aaron R. McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

IPC分类号： A61N1/365

CPC分类号： A61N1/36114 ,  A61N1/36053 ,  A61N1/3606 ,  A61N1/36128 ,  A61N1/36139

摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

公开(公告)号：US09031650B2

公开(公告)日：2015-05-12

申请号：US12986762

申请日：2011-01-07

申请人： Aaron R. McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

发明人： Aaron R. McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

IPC分类号： A61N1/365 ,  A61N1/36

CPC分类号： A61N1/36139 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/365 ,  A61N1/36592 ,  A61N1/3962 ,  A61N1/3987

摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

摘要翻译： 本主题的各个方面涉及一种方法。 根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。

公开(公告)号：US20110106199A1

公开(公告)日：2011-05-05

申请号：US12986762

申请日：2011-01-07

申请人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

发明人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

IPC分类号： A61N1/365

CPC分类号： A61N1/36139 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/365 ,  A61N1/36592 ,  A61N1/3962 ,  A61N1/3987

摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

摘要翻译： 本主题的各个方面涉及一种方法。 根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。

公开(公告)号：US20100121399A1

公开(公告)日：2010-05-13

申请号：US12688575

申请日：2010-01-15

申请人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

发明人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

IPC分类号： A61N1/365

CPC分类号： A61N1/36114 ,  A61N1/36053 ,  A61N1/3606 ,  A61N1/36128 ,  A61N1/36139

摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

摘要翻译： 本主题的各个方面涉及一种方法。 根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。

公开(公告)号：US07873413B2

公开(公告)日：2011-01-18

申请号：US11459481

申请日：2006-07-24

申请人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

发明人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

IPC分类号： A61N1/36

CPC分类号： A61N1/36139 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/365 ,  A61N1/36592 ,  A61N1/3962 ,  A61N1/3987

摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

摘要翻译： 本主题的各个方面涉及一种方法。 根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。

公开(公告)号：US20080021504A1

公开(公告)日：2008-01-24

申请号：US11459481

申请日：2006-07-24

申请人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

发明人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

IPC分类号： A61N1/36

CPC分类号： A61N1/36139 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/365 ,  A61N1/36592 ,  A61N1/3962 ,  A61N1/3987

摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

摘要翻译： 本主题的各个方面涉及一种方法。 根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。

公开(公告)号：US08452398B2

公开(公告)日：2013-05-28

申请号：US12469012

申请日：2009-05-20

申请人： Imad Libbus ,  Paul A. Haefner ,  Aaron R. McCabe ,  Yi Zhang

发明人： Imad Libbus ,  Paul A. Haefner ,  Aaron R. McCabe ,  Yi Zhang

IPC分类号： A61N1/365

CPC分类号： A61N1/36135 ,  A61N1/36114 ,  A61N1/365 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571

摘要： A neural stimulator senses a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using a sensor external to the heart and blood vessels. The delivery of the neural stimulation pulses are synchronized to that timing reference event. Examples of the timing reference event include a predetermined cardiac event such as a P-wave or an R-wave detected from a subcutaneous ECG signal, a predetermined type heart sound detected from an acoustic signal, and a peak detected from a hemodynamic signal related to blood flow or pressure.

公开(公告)号：US20090228060A1

公开(公告)日：2009-09-10

申请号：US12469012

申请日：2009-05-20

申请人： Imad Libbus ,  Paul A. Haefner ,  Aaron R. McCabe ,  Yi Zhang

发明人： Imad Libbus ,  Paul A. Haefner ,  Aaron R. McCabe ,  Yi Zhang

IPC分类号： A61N1/365

CPC分类号： A61N1/36135 ,  A61N1/36114 ,  A61N1/365 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571

摘要： A neural stimulator senses a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using a sensor external to the heart and blood vessels. The delivery of the neural stimulation pulses are synchronized to that timing reference event. Examples of the timing reference event include a predetermined cardiac event such as a P-wave or an R-wave detected from a subcutaneous ECG signal, a predetermined type heart sound detected from an acoustic signal, and a peak detected from a hemodynamic signal related to blood flow or pressure.

摘要翻译： 神经刺激器感测指示心脏周期的参考信号，每个参考信号包括使用心脏和血管外部的传感器的预定类型的定时参考事件。 神经刺激脉冲的输送与该定时参考事件同步。 定时参考事件的示例包括预定的心脏事件，例如从皮下ECG信号检测到的P波或R波，从声信号检测到的预定类型心音，以及从与 血流或压力。

公开(公告)号：US07542800B2

公开(公告)日：2009-06-02

申请号：US11099141

申请日：2005-04-05

申请人： Imad Libbus ,  Paul A. Haefner ,  Aaron McCabe ,  Yi Zhang

发明人： Imad Libbus ,  Paul A. Haefner ,  Aaron McCabe ,  Yi Zhang

IPC分类号： A61N1/36

CPC分类号： A61N1/36135 ,  A61N1/36114 ,  A61N1/365 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571

摘要： A neural stimulator senses a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using a sensor external to the heart and blood vessels. The delivery of the neural stimulation pulses are synchronized to that timing reference event. Examples of the timing reference event include a predetermined cardiac event such as a P-wave or an R-wave detected from a subcutaneous ECG signal, a predetermined type heart sound detected from an acoustic signal, and a peak detected from a hemodynamic signal related to blood flow or pressure.

摘要翻译： 神经刺激器感测指示心脏周期的参考信号，每个参考信号包括使用心脏和血管外部的传感器的预定类型的定时参考事件。 神经刺激脉冲的输送与该定时参考事件同步。 定时参考事件的示例包括预定的心脏事件，例如从皮下ECG信号检测到的P波或R波，从声信号检测到的预定类型心音，以及从与 血流或压力。