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公开(公告)号：US20190048069A1
公开(公告)日：2019-02-14
申请号：US15908285
申请日：2018-02-28
Applicant: AbbVie Inc.
Inventor： Christopher M. CHUMSAE
Abstract: Methylglyoxal (MGO)-modified recombinant TNF-alpha antibodies (e.g., Adalimumab) are identified. MGO modification decreases binding between Adalimumab and TNF-alpha. Methods are disclosed for reducing the presence of MGO-modified antibodies in the production of Adalimumab TNF-alpha antibodies.
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2.发明申请Human Antibodies that Bind Human TNF-Alpha and Methods of Preparing the Same 审中-公开绑定人类TNF-α的人抗体及其制备方法公开(公告)号：US20170029495A1
公开(公告)日：2017-02-02
申请号：US15297055
申请日：2016-10-18
Applicant: AbbVie Inc.
Inventor： Christopher M. CHUMSAE
CPC classification number: C07K16/241 , B01D15/362 , C07K1/18 , C07K2317/21 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N30/96
Abstract: Methylglyoxal (MGO)-modified recombinant TNF-alpha antibodies (e.g., Adalimumab) are identified. MGO modification decreases binding between Adalimumab and TNF-alpha. Methods are disclosed for reducing the presence of MGO-modified antibodies in the production of Adalimumab TNF-alpha antibodies.
Abstract translation: 鉴定了甲基乙二醛（MGO）修饰的重组TNF-α抗体（例如阿达木单抗）。 MGO修饰降低阿达木单抗与TNF-α之间的结合。 公开了用于在产生阿达木单抗TNF-α抗体中减少MGO修饰的抗体的存在的方法。
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3.发明申请公开(公告)号：US20170121403A1
公开(公告)日：2017-05-04
申请号：US15353116
申请日：2016-11-16
Applicant: AbbVie, Inc.
Inventor： Kartik SUBRAMANIAN , Mayda Perez THIELE , Xiaobei ZENG , Chee Furng WONG , Zehra KAYMAKCALAN , Ying JING , Christopher M. CHUMSAE
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C12P21/005
Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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