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1.发明申请公开(公告)号：US20190233510A1
公开(公告)日：2019-08-01
申请号：US16055659
申请日：2018-08-06
发明人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole Teusch
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07H21/00 , C07K16/2863 , C07K2317/14 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
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2.发明申请NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NgR) AND USES THEREOF 审中-公开去除NOGO-66受体（NgR）的单克隆抗体及其用途公开(公告)号：US20160145334A1
公开(公告)日：2016-05-26
申请号：US14989532
申请日：2016-01-06
发明人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole Teusch
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07H21/00 , C07K16/2863 , C07K2317/14 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
摘要翻译： 本发明涉及结合Nogo-66受体的分离的蛋白质，特别是单克隆抗体。 具体地说，这些抗体具有抑制Nogo-66受体的天然配体结合并中和Nogo-66受体的能力。 本发明的这些抗体或其部分可用于检测NgR和抑制NgR活性，例如在患有NgR或Nogo-66活性有害的病症的人中。
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公开(公告)号：US10040852B2
公开(公告)日：2018-08-07
申请号：US14989532
申请日：2016-01-06
发明人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole Teusch
IPC分类号： C07K16/28 , A61K39/395 , C07H21/00 , A61K39/00
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
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4.发明授权Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR) and uses thereof 有权针对Nogo-66受体（NgR）的中和单克隆抗体及其用途公开(公告)号：US09255146B2
公开(公告)日：2016-02-09
申请号：US14013916
申请日：2013-08-29
发明人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole Teusch
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07H21/00 , C07K16/2863 , C07K2317/14 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
摘要翻译： 本发明涉及结合Nogo-66受体的分离的蛋白质，特别是单克隆抗体。 具体地说，这些抗体具有抑制Nogo-66受体的天然配体结合并中和Nogo-66受体的能力。 本发明的这些抗体或其部分可用于检测NgR和抑制NgR活性，例如在患有NgR或Nogo-66活性有害的病症的人中。
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5.发明申请NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NgR) AND USES THEREOF 有权去除NOGO-66受体（NgR）的单克隆抗体及其用途公开(公告)号：US20140065155A1
公开(公告)日：2014-03-06
申请号：US14013916
申请日：2013-08-29
发明人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole Teusch
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07H21/00 , C07K16/2863 , C07K2317/14 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
摘要翻译： 本发明涉及结合Nogo-66受体的分离的蛋白质，特别是单克隆抗体。 具体地说，这些抗体具有抑制Nogo-66受体的天然配体结合并中和Nogo-66受体的能力。 本发明的这些抗体或其部分可用于检测NgR和抑制NgR活性，例如在患有NgR或Nogo-66活性有害的病症的人中。
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