公开(公告)号：US20220213092A1

公开(公告)日：2022-07-07

申请号：US17552396

申请日：2021-12-16

Applicant: AbbVie Inc.

Inventor： David A. DeGoey ,  Felix DeAnda, Jr. ,  Amanda W. Dombrowski ,  Igor Dubovyk ,  Stephen N. Greszler ,  Dimitri Khrakovsky ,  Chih-Hung Lee ,  James N. Newton ,  Elizabeth L. Noey ,  Akinori Okano ,  Kevin B. Sippy ,  Andrew J. Souers ,  Longcheng Wang ,  Noel S. Wilson ,  Jeffery A. Zablocki

IPC: C07D471/04 ,  C07D519/00 ,  C07D487/04

Abstract: The present invention provides for compounds of formula (I) wherein A, R1, R2, R4, W, m, and n have any of the values defined herein, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL and/or SLL.

公开(公告)号：US10266532B2

公开(公告)日：2019-04-23

申请号：US15829243

申请日：2017-12-01

Applicant: AbbVie Inc.

Inventor： Eric C. Breinlinger ,  Phil B. Cox ,  Justin D. Dietrich ,  Kristine E. Frank ,  Michael M. Friedman ,  Huan-Qui Li ,  Kenton L. Longenecker ,  Augustine T. Osuma ,  Ann Marie Rowley ,  Anil Vasudevan ,  Noel S. Wilson ,  Jerome Daanen ,  Stevan Djuric ,  Amanda W. Dombrowski ,  Arthur Gomtsyan ,  Robert Schmidt

IPC: C07D521/00 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D498/04 ,  C07D498/14 ,  C07D498/18 ,  C07D498/20 ,  C07D498/22 ,  C07D519/00 ,  C07D471/18 ,  C07D491/147 ,  C07D491/22

Abstract: The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.

公开(公告)号：US20160304517A1

公开(公告)日：2016-10-20

申请号：US15130362

申请日：2016-04-15

Applicant: AbbVie Inc.

Inventor： Eric C. Breinlinger ,  Phil B. Cox ,  Jerome Daanen ,  Justin Dietrich ,  Stevan Djuric ,  Amanda W. Dombrowski ,  Kristine E. Frank ,  Michael M. Friedman ,  Arthur Gomtsyan ,  Huan-Qui Li ,  Kenton Longenecker ,  Augustine Osuma ,  Ann Marie Rowley ,  Robert Schmidt ,  Anil Vasudevan ,  Noel Wilson

IPC: C07D471/04 ,  C07D491/147 ,  C07D491/22 ,  C07D498/04 ,  C07D471/18 ,  C07D471/14 ,  C07D498/22 ,  C07D498/14 ,  C07D498/20 ,  C07D487/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D471/14 ,  C07D471/18 ,  C07D487/04 ,  C07D491/147 ,  C07D491/22 ,  C07D498/04 ,  C07D498/14 ,  C07D498/18 ,  C07D498/20 ,  C07D498/22 ,  C07D519/00

Abstract: The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供三环杂环化合物，药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。