公开(公告)号：US20180086737A1

公开(公告)日：2018-03-29

申请号：US15670708

申请日：2017-08-07

Applicant: AbbVie Inc.

Inventor： Maria Argiriadi ,  Eric Breinlinger ,  Justin D. Dietrich ,  Michael Friedman ,  David Ihle ,  Michael Morytko ,  Kelly Mullen ,  Augustine Osuma ,  Gloria Y. LoSchiavo ,  Noel S. Wilson

IPC: C07D403/04 ,  C07F9/6558 ,  C07D401/14 ,  C07D413/04 ,  C07D471/04 ,  C07D498/04 ,  C07D491/107 ,  C07D487/04 ,  C07D417/14 ,  C07D417/04 ,  C07D403/14 ,  C07D401/04 ,  C07D413/14 ,  C07D405/14 ,  C07D405/04

CPC classification number: C07D403/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D498/04 ,  C07F9/65583

Abstract: The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.

公开(公告)号：US20180215764A1

公开(公告)日：2018-08-02

申请号：US15852179

申请日：2017-12-22

Applicant: AbbVie Inc.

Inventor： Eric C. Breinlinger ,  Andrew Burchat ,  Justin D. Dietrich ,  Michael Friedman ,  David Ihle ,  David Kinsman ,  Kelly Mullen ,  Augustine T. Osuma ,  Anil Vasudevan ,  Noel S. Wilson

IPC: C07D487/04 ,  C07D519/00 ,  C07D498/04

CPC classification number: C07D487/04 ,  C07D498/04 ,  C07D519/00

Abstract: The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.

公开(公告)号：US10273238B2

公开(公告)日：2019-04-30

申请号：US15852179

申请日：2017-12-22

Applicant: AbbVie Inc.

Inventor： Eric C. Breinlinger ,  Andrew Burchat ,  Justin Dietrich ,  Michael Friedman ,  David Ihle ,  David Kinsman ,  Kelly Mullen ,  Augustine Osuma ,  Anil Vasudevan ,  Noel S. Wilson

IPC: C07D487/04 ,  C07D519/00 ,  C07D498/04

Abstract: The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.

公开(公告)号：US20160304526A1

公开(公告)日：2016-10-20

申请号：US15130323

申请日：2016-04-15

Applicant: AbbVie Inc.

Inventor： Eric Breinlinger ,  Andrew Burchat ,  Justin Dietrich ,  Michael Friedman ,  David Ihle ,  David Kinsman ,  Kelly Mullen ,  Augustine Osuma ,  Anil Vasudevan ,  Noel Wilson

IPC: C07D487/04 ,  C07D498/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D498/04 ,  C07D519/00

Abstract: The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.

Abstract translation: 药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本公开的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：US10160748B2

公开(公告)日：2018-12-25

申请号：US15670708

申请日：2017-08-07

Applicant: AbbVie Inc.

Inventor： Maria Argiriadi ,  Eric Breinlinger ,  Justin D. Dietrich ,  Michael Friedman ,  David Ihle ,  Michael Morytko ,  Kelly Mullen ,  Augustine Osuma ,  Gloria Y. LoSchiavo ,  Noel S. Wilson

IPC: C07D403/04 ,  C07F9/6558 ,  C07D413/04 ,  C07D471/04 ,  C07D405/04 ,  C07D491/107 ,  C07D487/04 ,  C07D401/14 ,  C07D417/04 ,  C07D403/14 ,  C07D498/04 ,  C07D401/04 ,  C07D413/14 ,  C07D405/14 ,  C07D417/14

Abstract: The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.

公开(公告)号：US09879016B2

公开(公告)日：2018-01-30

申请号：US15130323

申请日：2016-04-15

Applicant: AbbVie Inc.

Inventor： Eric Breinlinger ,  Andrew Burchat ,  Justin Dietrich ,  Michael Friedman ,  David Ihle ,  David Kinsman ,  Kelly Mullen ,  Augustine Osuma ,  Anil Vasudevan ,  Noel Wilson

IPC: C07D487/04 ,  C07D498/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D498/04 ,  C07D519/00

Abstract: The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.

公开(公告)号：US20160304496A1

公开(公告)日：2016-10-20

申请号：US15130279

申请日：2016-04-15

Applicant: AbbVie Inc.

Inventor： Maria Argiriadi ,  Eric Breinlinger ,  Justin D. Dietrich ,  Michael Friedman ,  David Ihle ,  Michael Morytko ,  Kelly Mullen ,  Augustine Osuma ,  Glora Y. Lo Schiavo ,  Noel S. Wilson

IPC: C07D403/04 ,  C07D403/14 ,  C07D491/107 ,  C07D405/14 ,  C07D487/04 ,  C07D405/04 ,  C07D417/14 ,  C07D401/04 ,  C07D417/04 ,  C07D413/04 ,  C07D471/04 ,  C07F9/6558 ,  C07D401/14 ,  C07D498/04

CPC classification number: C07D403/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D498/04 ,  C07F9/65583

Abstract: The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.

Abstract translation: 本公开提供吲哚酮化合物，药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本公开的化合物可用于治疗免疫学和肿瘤学病症。