公开(公告)号：US20180235962A1

公开(公告)日：2018-08-23

申请号：US15957433

申请日：2018-04-19

Applicant: AbbVie Inc.

Inventor： Ping X. GAO ,  Raimundo HO ,  Jayanthy JAYANTH ,  Samrat MUKHERJEE ,  Katherine E. PETERSON ,  John C. STRONG ,  Ping TONG ,  Geoff ZHANG

IPC: A61K31/505 ,  A61K9/16 ,  B01F11/02 ,  A61J3/02

CPC classification number: A61K31/505 ,  A61K9/1688 ,  A61K31/513 ,  B01F11/02 ,  B01F2215/0032

Abstract: A process for acoustically mixing a bulk drug substance involves the application of acoustic energy to drive an accelerative force in a mixing vessel containing the drug substance. The drug substance may be, for example, Elagolix.

公开(公告)号：US20140018518A1

公开(公告)日：2014-01-16

申请号：US13939873

申请日：2013-07-11

Applicant: AbbVie Inc.

Inventor： Ahmad Y. SHEIKH ,  Moiz DIWAN ,  Agnes E. PAL ,  Yuchuan GONG ,  Paul J. BRACKEMEYER ,  Geoff ZHANG ,  Seble WAGAW

IPC: C07K5/12

CPC classification number: C07K5/123 ,  C07D487/04 ,  C07K5/0804

Abstract: The present invention features crystalline forms of Compound I. In one embodiment, a crystalline form of Compound I has characteristic peaks in the PXRD pattern at values of two theta (° 2θ) of 10.7, 11.6, 12.7, 13.0, 13.2, 13.7, 14.5, 18.7, 19.0, and 19.9 after equilibration at 43% relative humidity.

Abstract translation: 本发明的特征在于化合物I的结晶形式。在一个实施方案中，化合物I的结晶形式在2θ（°2θ）为10.7,11.6,12.7,13.0,13.2,13.7,14.5的值的PXRD图中具有特征峰 ，18.7,19​​.0和19.9，在43％相对湿度下平衡后。