公开(公告)号：US20180235962A1

公开(公告)日：2018-08-23

申请号：US15957433

申请日：2018-04-19

Applicant: AbbVie Inc.

Inventor： Ping X. GAO ,  Raimundo HO ,  Jayanthy JAYANTH ,  Samrat MUKHERJEE ,  Katherine E. PETERSON ,  John C. STRONG ,  Ping TONG ,  Geoff ZHANG

IPC: A61K31/505 ,  A61K9/16 ,  B01F11/02 ,  A61J3/02

CPC classification number: A61K31/505 ,  A61K9/1688 ,  A61K31/513 ,  B01F11/02 ,  B01F2215/0032

Abstract: A process for acoustically mixing a bulk drug substance involves the application of acoustic energy to drive an accelerative force in a mixing vessel containing the drug substance. The drug substance may be, for example, Elagolix.

公开(公告)号：US20160106765A1

公开(公告)日：2016-04-21

申请号：US14919418

申请日：2015-10-21

Applicant: AbbVie Inc.

Inventor： Benoit CARDINAL-DAVID ,  Vincent S. CHAN ,  Kassibla E. DEMPAH ,  Brian P. ENRIGHT ,  Rodger F. HENRY ,  Raimundo HO ,  Ye HUANG ,  Alexander D. HUTERS ,  Russell C. KLIX ,  Scott W. KRABBE ,  Philip R. KYM ,  Yanbin LAO ,  Xiaochun LOU ,  Sean E. MACKEY ,  Mark A. MATULENKO ,  Peter T. MAYER ,  Christopher P. MILLER ,  James STAMBULI ,  Eric A. VOIGHT ,  Zhi WANG ,  Geoff G. ZHANG ,  Valentino J. STELLA

IPC: A61K31/661 ,  C07F9/06

CPC classification number: C07F9/094 ,  A61K31/661 ,  A61K31/6615 ,  A61K45/06 ,  C07B2200/13 ,  C07C47/277 ,  C07C281/02 ,  C07C309/24 ,  C07F9/06 ,  A61K2300/00

Abstract: The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

Abstract translation: 本公开内容涉及（a）卡比多巴前药，（b）药物组合和包含卡比多巴前药和/或左旋多巴前药的组合物，和（c）治疗帕金森病和相关病症的方法，包括施用卡比多巴前药和 左旋多巴前药与帕金森病患者。

公开(公告)号：US20170007600A1

公开(公告)日：2017-01-12

申请号：US15204217

申请日：2016-07-07

Applicant: AbbVie Inc.

Inventor： Ping X. GAO ,  Raimundo HO ,  Jayanthy JAYANTH ,  Samrat MUKHERJEE ,  Katherine E. PETERSON ,  John C. STRONG ,  Ping TONG ,  Geoff G. ZHANG

IPC: A61K31/505 ,  A61K9/16 ,  A61J3/02 ,  B01F15/00

CPC classification number: A61K31/505 ,  A61J3/02 ,  A61K9/1688 ,  B01F11/02 ,  B01F2215/0032

Abstract: A process for acoustically mixing a bulk drug substance involves the application of acoustic energy to drive an accelerative force in a mixing vessel containing the drug substance. The drug substance may be, for example, Elagolix.

Abstract translation: 用于声学混合散装药物的方法包括施加声能以驱动含有药物物质的混合容器中的加速力。 药物可以是例如Elagolix。

公开(公告)号：US20160362431A1

公开(公告)日：2016-12-15

申请号：US15216009

申请日：2016-07-21

Applicant: AbbVie, Inc.

Inventor： Benoit CARDINAL-DAVID ,  Vincent S. CHAN ,  Kassibla DEMPAH ,  Brian P. ENRIGHT ,  Rodger F. HENRY ,  Raimundo HO ,  Ye HUANG ,  Alexander D. HUTERS ,  Russell C. KLIX ,  Scott W. KRABBE ,  Philip R. KYM ,  Yanbin LAO ,  Xiaochun LOU ,  Sean E. MACKEY ,  Mark A. MATULENKO ,  Peter T. MAYER ,  Christopher P. MILLER ,  James STAMBULI ,  Eric A. VOIGHT ,  Zhi WANG ,  Geoff G. ZHANG ,  Valentino J. STELLA

IPC: C07F9/09 ,  A61K31/661 ,  A61K45/06 ,  C07F9/06 ,  A61K31/6615

Abstract: The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

Abstract translation: 本公开内容涉及（a）卡比多巴前药，（b）药物组合和包含卡比多巴前药和/或左旋多巴前药的组合物，和（c）治疗帕金森病和相关病症的方法，包括施用卡比多巴前药和 左旋多巴前药与帕金森病患者。