公开(公告)号：US20210154207A1

公开(公告)日：2021-05-27

申请号：US17047871

申请日：2018-07-23

Applicant: AbbVie Inc.

Inventor： Kristof Chwalisz ,  Jane Castelli-Haley ,  Oscar Antunez Flores ,  Keith Gordon ,  Rita Jain ,  Juki Wing-Keung Ng ,  Janine D. North ,  Charlotte D. Owens ,  Hannah Palac ,  Paul M. Peloso ,  Michael C. Snabes ,  Ahmed M. Soliman ,  James W. Thomas

IPC: A61K31/57 ,  A61K31/567 ,  A61K31/513 ,  A61P15/00

Abstract: The present invention relates to the method of treating heavy menstrual bleeding in a subject with or without uterine fibroids and in need of treatment by administering an effective amount of 4-((R)-2-[5-(2-fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethylamino)-butyric acid or a pharmaceutically acceptable salt thereof, in combination with estrogens and progestogens.

公开(公告)号：US20190054088A1

公开(公告)日：2019-02-21

申请号：US16105396

申请日：2018-08-20

Applicant: AbbVie Inc. ,  Neurocrine Biosciences, Inc.

Inventor： Jayanthy Jayanth ,  Kevin C. Spence ,  Gregory A. McClelland ,  Anna V. Stepanenko ,  Kristof Chwalisz ,  Charlotte D. Owens ,  James W. Thomas ,  Jane Castelli-Haley ,  Keith Gordon ,  Michael C. Snabes ,  Ahmed M. Soliman ,  Geoff Zhang ,  David Metzger ,  Yanxia Li ,  Tzuchi R. Ju ,  Xi Shao ,  Oscar Antunez Flores ,  Rita Jain ,  Juki Wing-Keung Ng ,  Janine D. North ,  Hannah Palac ,  Paul M. Peloso ,  Laura A. Williams

IPC: A61K31/513 ,  A61K9/20 ,  A61P15/00 ,  A61P5/30

Abstract: The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using such compositions. The disclosure also relates to methods of facilitating release of a GnRH antagonist from a pharmaceutical composition.

公开(公告)号：US20230255968A1

公开(公告)日：2023-08-17

申请号：US18168221

申请日：2023-02-13

Applicant: AbbVie Inc. ,  Neurocrine Biosciences, Inc.

Inventor： Jayanthy Jayanth ,  Kevin C. Spence ,  Gregory A. McClelland ,  Anna V. Stepanenko ,  Kristof Chwalisz ,  Charlotte D. Owens ,  James W. Thomas ,  Jane Castelli-Haley ,  Keith Gordon ,  Michael C. Snabes ,  Ahmed M. Soliman ,  Geoff Zhang ,  David Metzger ,  Yanxia Li ,  Tzuchi R. Ju ,  Xi Shao ,  Oscar Antunez Flores ,  Rita Jain ,  Juki Wing-Keung Ng ,  Janine D. North ,  Hannah Palac ,  Paul M. Peloso

IPC: A61K31/513 ,  A61K9/20 ,  A61P5/30 ,  A61P15/00

CPC classification number: A61K31/513 ,  A61K9/2009 ,  A61K9/2018 ,  A61P5/30 ,  A61K9/2059 ,  A61P15/00 ,  A61K9/2027

Abstract: The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using such compositions. The disclosure also relates to methods of facilitating release of a GnRH antagonist from a pharmaceutical composition.

公开(公告)号：US20190054027A1

公开(公告)日：2019-02-21

申请号：US16105440

申请日：2018-08-20

Applicant: AbbVie Inc.

Inventor： Yihong Qiu ,  Yuchuan Gong ,  Alexander Ruggles ,  Jared A. Baird ,  Kristof Chwalisz ,  Charlotte D. Owens ,  James W. Thomas ,  Jane Castelli-Haley ,  Keith Gordon ,  Michael C. Snabes ,  Ahmed M. Soliman ,  Oscar Antunez Flores ,  Rita Jain ,  Juki Wing-Keung Ng ,  Janine D. North ,  Hannah Palac ,  Paul M. Peloso ,  Laura A. Williams ,  Hui Zu ,  Yuerong Hu

IPC: A61K9/20 ,  A61K31/513 ,  A61P15/00

Abstract: The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using such compositions. The disclosure also relates to methods of facilitating release of a GnRH antagonist from a pharmaceutical composition.

公开(公告)号：US20230277556A1

公开(公告)日：2023-09-07

申请号：US18317718

申请日：2023-05-15

Applicant: AbbVie Inc.

Inventor： Kristof Chwalisz ,  Jane Castelli-Haley ,  Oscar Antunez Flores ,  Keith Gordon ,  Rita Jain ,  Juki Wing-Keung Ng ,  Janine D. North ,  Charlotte D. Owens ,  Hannah Palac ,  Paul M. Peloso ,  Michael C. Snabes ,  Ahmed M. Soliman ,  James W. Thomas ,  Mohamad Shebley

IPC: A61K31/57 ,  A61P15/00 ,  A61K31/513 ,  A61K31/567

CPC classification number: A61K31/57 ,  A61P15/00 ,  A61K31/513 ,  A61K31/567

Abstract: The present invention relates to the method of treating heavy menstrual bleeding in a subject with or without uterine fibroids and in need of treatment by administering an effective amount of 4-((R)-2-[5-(2-fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethylamino)-butyric acid or a pharmaceutically acceptable salt thereof, in combination with estrogens and progestogens.

公开(公告)号：US20160136154A1

公开(公告)日：2016-05-19

申请号：US14946643

申请日：2015-11-19

Applicant: AbbVie Inc.

Inventor： Rita I. Jain ,  Andrea E. Best ,  Earle Lockhart ,  Steven E. Marx ,  James W. Thomas ,  Pamela Giang Vo

IPC: A61K31/485 ,  A61K31/167

CPC classification number: A61K31/485 ,  A61K31/165 ,  A61K31/167 ,  A61K31/439 ,  A61K2300/00

Abstract: The present invention generally provides a method of treatment and improvement of quality of life for patients adversely affected by various pain conditions. One preferred embodiment provides a method of treatment of acute pain, moderate to moderately severe pain, chronic pain, non-cancer pain, osteoarthritic pain, bunionectomy pain or lower back pain in a patient in need thereof, comprising providing at least one or two dosage form having about 15 mg of hydrocodone and its salt and about 500 mg of acetaminophen, once, twice or thrice daily. Preferably, the dosage form is about 30 mg of hydrocodone and about 1000 mg of acetaminophen taken twice daily. Alternatively, the dosage form is about 15 mg of hydrocodone and about 500 mg of acetaminophen taken twice daily.

Abstract translation: 本发明通常提供一种治疗和改善由各种疼痛状况不利影响的患者的生活质量的方法。 一个优选的实施方案提供了治疗有需要的患者的急性疼痛，中度至中度重度疼痛，慢性疼痛，非癌症疼痛，骨关节炎疼痛，骨髓切除术疼痛或下背痛的方法，包括提供至少一个或两个剂量 形式具有约15mg的氢可酮及其盐和约500mg的对乙酰氨基酚，每日一次，两次或三次。 优选地，剂型为约30mg氢可酮，约1000mg对乙酰氨基酚每天服用两次。 或者，剂型为约15mg氢可酮，约500mg对乙酰氨基酚每天服用两次。