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公开(公告)号：US20160362431A1
公开(公告)日：2016-12-15
申请号：US15216009
申请日：2016-07-21
申请人： AbbVie, Inc.
发明人： Benoit CARDINAL-DAVID , Vincent S. CHAN , Kassibla DEMPAH , Brian P. ENRIGHT , Rodger F. HENRY , Raimundo HO , Ye HUANG , Alexander D. HUTERS , Russell C. KLIX , Scott W. KRABBE , Philip R. KYM , Yanbin LAO , Xiaochun LOU , Sean E. MACKEY , Mark A. MATULENKO , Peter T. MAYER , Christopher P. MILLER , James STAMBULI , Eric A. VOIGHT , Zhi WANG , Geoff G. ZHANG , Valentino J. STELLA
IPC分类号： C07F9/09 , A61K31/661 , A61K45/06 , C07F9/06 , A61K31/6615
摘要： The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.
摘要翻译： 本公开内容涉及（a）卡比多巴前药，（b）药物组合和包含卡比多巴前药和/或左旋多巴前药的组合物，和（c）治疗帕金森病和相关病症的方法，包括施用卡比多巴前药和 左旋多巴前药与帕金森病患者。
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2.发明申请公开(公告)号：US20160206584A1
公开(公告)日：2016-07-21
申请号：US15001392
申请日：2016-01-20
申请人： AbbVie, Inc.
发明人： Rajkumar CONJEEVARAM , Alexandru DEAC , Ye HUANG , Sean E. MACKEY , Randy A. MENGES , Jayne ZIMMERMAN
CPC分类号： A61K31/198 , A61K9/0019 , A61K9/0053 , A61K9/10 , A61K45/06 , A61K47/10 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： The present disclosure relates to (a) an improved pharmaceutical composition comprising a levodopa active agent and a carbidopa active agent (b) methods of producing the pharmaceutical composition and (c) methods of treating Parkinson's disease and associated conditions comprising administering the pharmaceutical composition to a subject with Parkinson's disease.
摘要翻译： 本公开涉及（a）包含左旋多巴活性剂和卡比多巴活性剂的改进的药物组合物（b）制备药物组合物的方法和（c）治疗帕金森病和相关病症的方法，包括将药物组合物施用于 患有帕金森病。
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公开(公告)号：US20210046029A1
公开(公告)日：2021-02-18
申请号：US16822892
申请日：2020-03-18
申请人： AbbVie Inc.
发明人： Rajkumar CONJEEVARAM , Alexandru DEAC , Ye HUANG , Sean E. MACKEY , Randy A. MENGES , Jayne ZIMMERMAN
摘要： The present disclosure relates to (a) an improved pharmaceutical composition comprising a levodopa active agent and a carbidopa active agent (b) methods of producing the pharmaceutical composition and (c) methods of treating Parkinson's disease and associated conditions comprising administering the pharmaceutical composition to a subject with Parkinson's disease.
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公开(公告)号：US20190142777A1
公开(公告)日：2019-05-16
申请号：US16161940
申请日：2018-10-16
申请人： AbbVie Inc.
发明人： Rajkumar Conjeevaram , Alexandru DEAC , Ye HUANG , Sean E. MACKEY , Randy A. MENGES , Jayne Zimmerman
摘要： The present disclosure relates to (a) an improved pharmaceutical composition comprising a levodopa active agent and a carbidopa active agent (b) methods of producing the pharmaceutical composition and (c) methods of treating Parkinson's disease and associated conditions comprising administering the pharmaceutical composition to a subject with Parkinson's disease.
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公开(公告)号：US20160106765A1
公开(公告)日：2016-04-21
申请号：US14919418
申请日：2015-10-21
申请人： AbbVie Inc.
发明人： Benoit CARDINAL-DAVID , Vincent S. CHAN , Kassibla E. DEMPAH , Brian P. ENRIGHT , Rodger F. HENRY , Raimundo HO , Ye HUANG , Alexander D. HUTERS , Russell C. KLIX , Scott W. KRABBE , Philip R. KYM , Yanbin LAO , Xiaochun LOU , Sean E. MACKEY , Mark A. MATULENKO , Peter T. MAYER , Christopher P. MILLER , James STAMBULI , Eric A. VOIGHT , Zhi WANG , Geoff G. ZHANG , Valentino J. STELLA
IPC分类号： A61K31/661 , C07F9/06
CPC分类号： C07F9/094 , A61K31/661 , A61K31/6615 , A61K45/06 , C07B2200/13 , C07C47/277 , C07C281/02 , C07C309/24 , C07F9/06 , A61K2300/00
摘要： The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.
摘要翻译： 本公开内容涉及（a）卡比多巴前药，（b）药物组合和包含卡比多巴前药和/或左旋多巴前药的组合物，和（c）治疗帕金森病和相关病症的方法，包括施用卡比多巴前药和 左旋多巴前药与帕金森病患者。
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