公开(公告)号：US20130085142A1

公开(公告)日：2013-04-04

申请号：US13627541

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li ,  Sachin V. Patel ,  Richard J. Perner ,  John T. Randolph ,  Michael R. Schrimpf ,  Kevin R. Woller ,  Zhiren Xia ,  Qingwei Zhang

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z 1，Z 2，Z 3，Z 4，R 1，R 2和R 3如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道抑制剂。

公开(公告)号：US08741899B2

公开(公告)日：2014-06-03

申请号：US13758615

申请日：2013-02-04

Applicant: AbbVie Inc.

Inventor： Qingwei Zhang ,  Andrew O. Stewart ,  Zhiren Xia

IPC: A61K31/495

CPC classification number: C07D487/04 ,  C07D211/58 ,  C07D401/04 ,  C07D471/04

Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及包含式（I），式（II），式（III）或式（IV）的化合物的钙通道抑制剂，其中L 1，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R c 如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：US20130210827A1

公开(公告)日：2013-08-15

申请号：US13758615

申请日：2013-02-04

Applicant: AbbVie Inc.

Inventor： Qingwei Zhang ,  Andrew O. Stewart ,  Zhiren Xia

IPC: C07D487/04 ,  C07D401/04 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07D211/58 ,  C07D401/04 ,  C07D471/04

Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及包含式（I），式（II），式（III）或式（IV）的化合物的钙通道抑制剂，其中L 1，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R c 如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：US20130178477A1

公开(公告)日：2013-07-11

申请号：US13734385

申请日：2013-01-04

Applicant: AbbVie Inc.

Inventor： Qingwei Zhang ,  Andrew O. Stewart ,  Zhiren Xia ,  Wolfram V. Nothaft

IPC: A61K31/4985

CPC classification number: A61K31/4985

Abstract: This invention is directed to methods of treating diabetic neuropathy, particularly, diabetic peripheral neuropathy, in a patient in need of treatment thereof.

Abstract translation: 本发明涉及在需要治疗的患者中治疗糖尿病性神经病变，特别是糖尿病性周围神经病变的方法。

公开(公告)号：US08669255B2

公开(公告)日：2014-03-11

申请号：US13627541

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li ,  Sachin V. Patel ,  Richard J. Perner ,  John T. Randolph ,  Michael R. Schrimpf ,  Kevin R. Woller ,  Zhiren Xia ,  Qingwei Zhang

IPC: A61K31/495

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z 1，Z 2，Z 3，Z 4，R 1，R 2和R 3如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道抑制剂。

公开(公告)号：US08648074B2

公开(公告)日：2014-02-11

申请号：US13627536

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li ,  Sachin V. Patel ,  Richard J. Perner ,  John T. Randolph ,  Michael R. Schrimpf ,  Kevin R. Woller ,  Zhiren Xia ,  Qingwei Zhang

IPC: A61K31/495

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z′, Z″, L2, G2, R1, and R2 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z'，Z“，L2，G2，R1和R2如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道阻滞剂。

公开(公告)号：US20130085141A1

公开(公告)日：2013-04-04

申请号：US13627536

申请日：2012-09-26

Applicant: ABBVie Inc.

Inventor： Tao Li ,  Sachin V. Patel ,  Richard J. Perner ,  John T. Randolph ,  Michael R. Schrimpf ,  Kevin R. Woller ,  Zhiren Xia ,  Qingwei Zhang

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z′, Z″, L2, G2, R1, and R2 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.

Abstract translation: 本申请涉及：（a）式（I）化合物及其盐，其中Z'，Z“，L2，G2，R1和R2如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道阻滞剂。