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公开(公告)号：US20240173307A1
公开(公告)日：2024-05-30
申请号：US18330171
申请日：2023-06-06
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Qingwei Zhang , Zhaoming Xiong , Ramzi Farah Sweis , Michael J. Dart , Kathleen J. Murauski
IPC: A61K31/44 , A61K31/165 , A61K31/18 , A61K31/341 , A61K31/35 , A61K31/381 , A61K31/4045 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/437 , A61K31/439 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/444 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K45/06 , A61P25/28 , C07C237/24 , C07C311/46 , C07C323/40 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/75 , C07D213/85 , C07D231/12 , C07D233/64 , C07D235/14 , C07D237/14 , C07D239/34 , C07D239/47 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D307/52 , C07D333/20 , C07D401/12 , C07D405/12 , C07D471/04 , C07D471/08 , C07D493/08
CPC classification number: A61K31/44 , A61K31/165 , A61K31/18 , A61K31/341 , A61K31/35 , A61K31/381 , A61K31/4045 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/437 , A61K31/439 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/444 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K45/06 , A61P25/28 , C07C237/24 , C07C311/46 , C07C323/40 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/75 , C07D213/85 , C07D231/12 , C07D233/64 , C07D235/14 , C07D237/14 , C07D239/34 , C07D239/47 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D307/52 , C07D333/20 , C07D401/12 , C07D405/12 , C07D471/04 , C07D471/08 , C07D493/08
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20240000792A1
公开(公告)日：2024-01-04
申请号：US18463183
申请日：2023-09-07
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph
IPC: A61K31/538 , A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/4045 , A61K31/472 , A61K45/06 , C07C235/22 , C07D209/08 , C07D209/42 , C07D217/16 , C07D265/36 , C07D307/85 , C07D311/66 , C07D317/46 , C07D319/20 , C07D405/12 , C07D413/06 , C07D413/12 , C07D493/04
CPC classification number: A61K31/538 , A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/4045 , A61K31/472 , A61K45/06 , C07C235/22 , C07D209/08 , C07D209/42 , C07D217/16 , C07D265/36 , C07D307/85 , C07D311/66 , C07D317/46 , C07D319/20 , C07D405/12 , C07D413/06 , C07D413/12 , C07D493/04
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20250115563A1
公开(公告)日：2025-04-10
申请号：US18647747
申请日：2024-04-26
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Yunsong Tong , Xiangdong Xu , Qingwei Zhang , Ramzi Farah Sweis , Michael J. Dart
IPC: C07D271/10 , A61K31/4245 , A61K31/4355 , A61K31/4439 , A61K45/06 , A61P25/28 , C07D233/96 , C07D271/06 , C07D401/12 , C07D413/12 , C07D491/048
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20240018133A1
公开(公告)日：2024-01-18
申请号：US18462918
申请日：2023-09-07
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph , Hanae Benelkebir
IPC: C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08
CPC classification number: C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08 , A61K45/06
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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![SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS](/abs-image/US/2013/04/04/US20130085142A1/abs.jpg.150x150.jpg)
5.发明申请SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS 有权取代的OCTAHYDROPRROLO [1,2-a]吡啶作为钙通道阻断剂公开(公告)号：US20130085142A1
公开(公告)日：2013-04-04
申请号：US13627541
申请日：2012-09-26
Applicant: AbbVie Inc.
Inventor： Tao Li , Sachin V. Patel , Richard J. Perner , John T. Randolph , Michael R. Schrimpf , Kevin R. Woller , Zhiren Xia , Qingwei Zhang
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.
Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z 1，Z 2，Z 3，Z 4，R 1，R 2和R 3如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道抑制剂。
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Patent Agency Ranking
公开(公告)号：US20250122188A1
公开(公告)日：2025-04-17
申请号：US18648195
申请日：2024-04-26
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC: C07D471/04 , A61P25/28 , C07C235/22 , C07C311/13 , C07C311/24 , C07C317/22 , C07D213/30 , C07D213/64 , C07D213/66 , C07D213/73 , C07D231/56 , C07D237/14 , C07D237/16 , C07D241/18 , C07D261/08 , C07D261/20 , C07D271/113 , C07D317/64 , C07D401/04 , C07D405/08
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20220106281A1
公开(公告)日：2022-04-07
申请号：US17108416
申请日：2020-12-01
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC: C07D307/82 , C07D213/74 , C07D231/14 , C07D237/10 , C07D241/12 , C07D241/44 , C07D261/08 , C07D277/32 , C07D213/57 , C07D307/56 , C07C233/74 , C07D213/54 , C07C235/54 , C07C233/79 , C07C255/41 , C07C255/57 , C07C235/14
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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![(4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo-[1,2-a]pyrazin-2(1H)-ylcarbonyl]-benzenesulfonamide, and pharmaceutically acceptable salts thereof](/abs-image/US/2014/06/03/US08741899B2/abs.jpg.150x150.jpg)
8.发明授权(4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo-[1,2-a]pyrazin-2(1H)-ylcarbonyl]-benzenesulfonamide, and pharmaceutically acceptable salts thereof 有权（4-氯-2-氟-N-（2-氟苯基）-5 - [（8aR） - 六氢吡咯并[1,2-a]吡嗪-2（1H） - 基羰基] - 苯磺酰胺及其药学上可接受的盐公开(公告)号：US08741899B2
公开(公告)日：2014-06-03
申请号：US13758615
申请日：2013-02-04
Applicant: AbbVie Inc.
Inventor： Qingwei Zhang , Andrew O. Stewart , Zhiren Xia
IPC: A61K31/495
CPC classification number: C07D487/04 , C07D211/58 , C07D401/04 , C07D471/04
Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本发明涉及包含式（I），式（II），式（III）或式（IV）的化合物的钙通道抑制剂，其中L 1，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R c 如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US20130210827A1
公开(公告)日：2013-08-15
申请号：US13758615
申请日：2013-02-04
Applicant: AbbVie Inc.
Inventor： Qingwei Zhang , Andrew O. Stewart , Zhiren Xia
IPC: C07D487/04 , C07D401/04 , C07D471/04
CPC classification number: C07D487/04 , C07D211/58 , C07D401/04 , C07D471/04
Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本发明涉及包含式（I），式（II），式（III）或式（IV）的化合物的钙通道抑制剂，其中L 1，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R c 如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
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10.发明申请公开(公告)号：US20130178477A1
公开(公告)日：2013-07-11
申请号：US13734385
申请日：2013-01-04
Applicant: AbbVie Inc.
Inventor： Qingwei Zhang , Andrew O. Stewart , Zhiren Xia , Wolfram V. Nothaft
IPC: A61K31/4985
CPC classification number: A61K31/4985
Abstract: This invention is directed to methods of treating diabetic neuropathy, particularly, diabetic peripheral neuropathy, in a patient in need of treatment thereof.
Abstract translation: 本发明涉及在需要治疗的患者中治疗糖尿病性神经病变，特别是糖尿病性周围神经病变的方法。
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