Patent search ap:("ABBVie Inc.") AND inv:"Richard J. Perner" Page 1

1.

发明申请
TRPA1 ANTAGONISTS 审中-公开

公开(公告)号：US20150065538A1

公开(公告)日：2015-03-05

申请号：US14532573

申请日：2014-11-04

Applicant: AbbVie Inc.

Inventor： Richard J. Perner , Michael E. Kort , Stanley DiDomenico , Jun Chen , Anil Vasudevan

IPC: C07D333/22 , A61K31/44 , A61K45/06 , A61K31/381 , A61K31/472 , C07D213/53 , C07D215/12 , A61K31/47 , C07D217/14 , C07D213/61 , C07D213/64

CPC classification number: C07D333/22 , A61K31/381 , A61K31/44 , A61K31/47 , A61K31/472 , A61K45/06 , C07D213/53 , C07D213/61 , C07D213/64 , C07D215/12 , C07D217/14 , C07D333/20

Abstract: Compounds of formula (I) wherein R1, R2, R3, and Y are defined in the description are TRPA1 antagonists.Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

2.

发明授权
TRPA1 antagonists 有权

公开(公告)号：US09751850B2

公开(公告)日：2017-09-05

申请号：US14532573

申请日：2014-11-04

Applicant: AbbVie Inc.

Inventor： Richard J. Perner , Michael E. Kort , Stanley DiDomenico , Jun Chen , Anil Vasudevan

IPC: A61K31/44 , A61K45/06 , A61K31/381 , C07D333/22 , C07D213/53 , C07D215/12 , C07D217/14 , C07D333/20 , A61K31/47 , A61K31/472 , C07D213/61 , C07D213/64

CPC classification number: C07D333/22 , A61K31/381 , A61K31/44 , A61K31/47 , A61K31/472 , A61K45/06 , C07D213/53 , C07D213/61 , C07D213/64 , C07D215/12 , C07D217/14 , C07D333/20

Abstract: Compounds of formula (I) wherein R1, R2, R3, and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

3.

发明申请
SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS 有权
Title translation: 取代的OCTAHYDROPRROLO [1,2-a]吡啶作为钙通道阻断剂

公开(公告)号：US20130085142A1

公开(公告)日：2013-04-04

申请号：US13627541

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li , Sachin V. Patel , Richard J. Perner , John T. Randolph , Michael R. Schrimpf , Kevin R. Woller , Zhiren Xia , Qingwei Zhang

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z 1，Z 2，Z 3，Z 4，R 1，R 2和R 3如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道抑制剂。

4.

发明授权
Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers 有权
Title translation: 取代的八氢吡咯并[1,2-a]吡嗪作为钙通道阻断剂

公开(公告)号：US08669255B2

公开(公告)日：2014-03-11

申请号：US13627541

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li , Sachin V. Patel , Richard J. Perner , John T. Randolph , Michael R. Schrimpf , Kevin R. Woller , Zhiren Xia , Qingwei Zhang

IPC: A61K31/495

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z 1，Z 2，Z 3，Z 4，R 1，R 2和R 3如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道抑制剂。

5.

发明授权
Substituted octahydropyrrolo[1,2-a]pyrazine sulfonamides as calcium channel blockers 有权
Title translation: 取代的八氢吡咯并[1,2-a]吡嗪磺酰胺作为钙通道阻断剂

公开(公告)号：US08648074B2

公开(公告)日：2014-02-11

申请号：US13627536

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li , Sachin V. Patel , Richard J. Perner , John T. Randolph , Michael R. Schrimpf , Kevin R. Woller , Zhiren Xia , Qingwei Zhang

IPC: A61K31/495

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z′, Z″, L2, G2, R1, and R2 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z'，Z“，L2，G2，R1和R2如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道阻滞剂。

6.

发明申请
SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINE SULFONAMIDES AS CALCIUM CHANNEL BLOCKERS 有权
Title translation: 取代的甲氧基吡咯并[1,2-a]吡啶磺酰胺作为钙通道阻断剂

公开(公告)号：US20130085141A1

公开(公告)日：2013-04-04

申请号：US13627536

申请日：2012-09-26

Applicant: ABBVie Inc.

Inventor： Tao Li , Sachin V. Patel , Richard J. Perner , John T. Randolph , Michael R. Schrimpf , Kevin R. Woller , Zhiren Xia , Qingwei Zhang

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z′, Z″, L2, G2, R1, and R2 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.

Abstract translation: 本申请涉及：（a）式（I）化合物及其盐，其中Z'，Z“，L2，G2，R1和R2如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道阻滞剂。

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