公开(公告)号：US20160375179A1

公开(公告)日：2016-12-29

申请号：US14750913

申请日：2015-06-25

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Jose R. Gamez ,  Karen Wang ,  Mary Beth Kossuth ,  Joel Harrington ,  James P. Oberhauser

IPC: A61L31/06 ,  A61F2/915 ,  A61L31/16 ,  A61F2/844

CPC classification number: A61L31/06 ,  A61F2/844 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0069 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/04

Abstract: Methods of fabricating a stent are disclosed including forming a primer layer on a surface of the scaffold including a first polylactide polymer. The primer layer includes a second polylactide polymer and is free of a therapeutic agent. The scaffold with the primer layer is thermally treated to condition the scaffold. A therapeutic layer is formed over the primer layer and the therapeutic layer includes the second polylactide polymer and a drug. The scaffold is crimped and the primer layer improves adhesion of the therapeutic layer to the scaffold and reduces or prevents damage to the therapeutic layer during crimping.

Abstract translation: 公开了制造支架的方法，包括在包括第一聚丙交酯聚合物的支架表面上形成底漆层。 底漆层包括第二聚丙交酯聚合物并且不含治疗剂。 将具有底漆层的支架进行热处理以调节支架。 在底漆层上形成治疗层，治疗层包括第二聚丙交酯聚合物和药物。 支架被卷曲，并且底漆层改善治疗层对支架的粘附，并减少或防止在卷曲期间对治疗层的损伤。