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公开(公告)号：US20180008438A1
公开(公告)日：2018-01-11
申请号：US15688486
申请日：2017-08-28
发明人： Rommel Lumauig , Stephen D. Pacetti , Ni Ding , Joel Harrington , Xiao Ma , James P. Oberhauser , Jill McCoy , Chad J. Abunassar , Senthil Eswaran , Diem Ta
IPC分类号： A61F2/915 , B29C71/02 , C08G63/08 , A61L31/14 , A61L31/06 , B29L31/00 , B29C35/08 , B29C35/04 , B29K67/00
CPC分类号： A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0004 , A61F2230/0069 , A61L31/06 , A61L31/14 , A61L31/148 , B29C71/0009 , B29C71/02 , B29C2035/046 , B29C2035/048 , B29C2035/0811 , B29C2035/0822 , B29C2035/0855 , B29C2035/0861 , B29C2071/022 , B29K2067/046 , B29K2995/006 , B29L2031/7534 , C08G63/08 , C08L67/04
摘要： Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.
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2.发明申请公开(公告)号：US20170319363A1
公开(公告)日：2017-11-09
申请号：US15661925
申请日：2017-07-27
CPC分类号： A61F2/90 , A61F2/91 , A61L31/041 , A61L31/06 , A61L31/148
摘要： Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.
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公开(公告)号：US09795497B2
公开(公告)日：2017-10-24
申请号：US14859170
申请日：2015-09-18
发明人： Rommel Lumauig , Stephen D. Pacetti , Ni Ding , Joel Harrington , Xiao Ma , James P. Oberhauser , Jill McCoy , Chad J. Abunassar , Senthil Eswaran , Diem Ta
IPC分类号： A61F2/82 , A61F2/91 , A61F2/915 , C08G63/08 , B29C71/02 , A61L31/06 , A61L31/14 , B29K67/00 , B29L31/00 , B29C35/04 , B29C35/08
CPC分类号： A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0004 , A61F2230/0069 , A61L31/06 , A61L31/14 , A61L31/148 , B29C71/0009 , B29C71/02 , B29C2035/046 , B29C2035/048 , B29C2035/0811 , B29C2035/0822 , B29C2035/0855 , B29C2035/0861 , B29C2071/022 , B29K2067/046 , B29K2995/006 , B29L2031/7534 , C08G63/08 , C08L67/04
摘要： Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.
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4.发明授权公开(公告)号：US10022906B2
公开(公告)日：2018-07-17
申请号：US14810344
申请日：2015-07-27
IPC分类号： B29C55/26 , B29C65/56 , A61F2/82 , B29C49/00 , B29C49/64 , B23P11/00 , B29C49/08 , B29K67/00 , B29L31/00 , A61L31/06 , A61L31/14 , B29L23/00
摘要： A polymer tube is processed using a solid phase process for improving mechanical characteristics of the tube, including radial strength and stiffness. The tube is made into a scaffold possessing improved mechanical and use characteristics, such as a reduced crimped profile and improved deliverability.
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公开(公告)号：US09750622B2
公开(公告)日：2017-09-05
申请号：US14307440
申请日：2014-06-17
CPC分类号： A61F2/90 , A61F2/91 , A61L31/041 , A61L31/06 , A61L31/148
摘要： Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.
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6.发明申请公开(公告)号：US20170112646A1
公开(公告)日：2017-04-27
申请号：US15399632
申请日：2017-01-05
CPC分类号： A61F2/915 , A61F2/06 , A61F2/82 , A61F2/91 , A61F2/958 , A61F2002/825 , A61F2002/91566 , A61F2002/91583 , A61F2210/0004 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/412 , C08L67/04
摘要： Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters.
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公开(公告)号：US20160375179A1
公开(公告)日：2016-12-29
申请号：US14750913
申请日：2015-06-25
CPC分类号： A61L31/06 , A61F2/844 , A61F2/915 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2230/0069 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L67/04
摘要： Methods of fabricating a stent are disclosed including forming a primer layer on a surface of the scaffold including a first polylactide polymer. The primer layer includes a second polylactide polymer and is free of a therapeutic agent. The scaffold with the primer layer is thermally treated to condition the scaffold. A therapeutic layer is formed over the primer layer and the therapeutic layer includes the second polylactide polymer and a drug. The scaffold is crimped and the primer layer improves adhesion of the therapeutic layer to the scaffold and reduces or prevents damage to the therapeutic layer during crimping.
摘要翻译： 公开了制造支架的方法，包括在包括第一聚丙交酯聚合物的支架表面上形成底漆层。 底漆层包括第二聚丙交酯聚合物并且不含治疗剂。 将具有底漆层的支架进行热处理以调节支架。 在底漆层上形成治疗层，治疗层包括第二聚丙交酯聚合物和药物。 支架被卷曲，并且底漆层改善治疗层对支架的粘附，并减少或防止在卷曲期间对治疗层的损伤。
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8.发明申请HIGH MOLECULAR WEIGHT POLYLACTIDE AND POLYCAPROLACTONE COPOLYMER AND BLENDS FOR BIORESORBABLE VASCULAR SCAFFOLDS 有权高分子量聚合物和聚碳酸酯共聚物和可生物降解血管的混合物公开(公告)号：US20150359648A1
公开(公告)日：2015-12-17
申请号：US14307440
申请日：2014-06-17
CPC分类号： A61F2/90 , A61F2/91 , A61L31/041 , A61L31/06 , A61L31/148
摘要： Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.
摘要翻译： 由具有高分子量聚合物的聚丙交酯和聚己内酯的组合制成的可生物再吸收的聚合物血管支架，在选定范围内的薄支柱和足够的径向强度以在部署时支撑血管。 支架具有有助于血管愈合的分子量，径向强度和质量的降解行为，包括向容器提供通畅性，降低径向强度，分解和再吸收以允许血管返回到自然状态。
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公开(公告)号：US10278844B2
公开(公告)日：2019-05-07
申请号：US15688486
申请日：2017-08-28
发明人： Rommel Lumauig , Stephen D. Pacetti , Ni Ding , Joel Harrington , Xiao Ma , James P. Oberhauser , Jill McCoy , Chad J. Abunassar , Senthil Eswaran , Diem Ta
IPC分类号： A61F2/915 , C08G63/08 , B29C71/02 , A61L31/06 , A61L31/14 , B29C71/00 , B29K67/00 , B29L31/00 , B29C35/04 , B29C35/08
摘要： Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.
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10.发明申请TUBE EXPANSION PROCESSES FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS 有权用于半结晶聚合物的管扩展方法以最大限度地减少破裂韧性公开(公告)号：US20140374963A1
公开(公告)日：2014-12-25
申请号：US14480484
申请日：2014-09-08
CPC分类号： B29C61/04 , B29C35/045 , B29C35/0805 , B29C71/0063 , B29C71/02 , B29C2035/0822 , B29C2071/022 , B29K2067/046 , B29K2105/258 , B29K2995/004 , B29K2995/006 , B29K2995/0089 , B29L2031/7534
摘要： Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold.
摘要翻译： 公开了制造具有改进的断裂韧性的聚合物支架的方法，包括聚合物管的径向膨胀和从膨胀管制造支架。 聚合物管设置在模具内并且可以用辐射加热。 加热管在模具内径向扩张。
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