公开(公告)号：US09168256B2

公开(公告)日：2015-10-27

申请号：US11928257

申请日：2007-10-30

申请人： Absar Faruqui ,  John A. Zebala ,  Barton A. Kamen

发明人： Absar Faruqui ,  John A. Zebala ,  Barton A. Kamen

IPC分类号： A61K31/519

CPC分类号： A61K31/519

摘要： There is disclosed stable pharmaceutical compositions containing pharmaceutically acceptable salts of aminopterin surface deposited onto solid excipients. The stable pharmaceutical compositions are hermetically sealed from the atmosphere. The formation of degradation products of aminopterin is reduced or eliminated.

摘要翻译： 公开了稳定的药物组合物，其含有沉积在固体赋形剂上的氨基蝶呤表面药学上可接受的盐。 将稳定的药物组合物与大气密封。 氨蝶呤的降解产物的形成被减少或消除。

公开(公告)号：US3972991A

公开(公告)日：1976-08-03

申请号：US451875

申请日：1974-03-18

申请人： J. Douglas Caston ,  Barton A. Kamen

发明人： J. Douglas Caston ,  Barton A. Kamen

IPC分类号： C07D475/04 ,  G01N33/82 ,  G21H5/02 ,  A61K43/00 ,  G01T1/16

CPC分类号： G01N33/82 ,  C07D475/04 ,  G21H5/02

摘要： There is provided a rapid and less costly radioisotopic assay for measuring the concentration of folate in blood serum. This procedure utilizes .sup.3 H-pteroylmonoglutamate, unlabeled 5-methyl-tetrahydrofolic acid, and a partially purified folate binder, such as for example a folate binder extracted from hog kidney. The procedure involves radioisotopically relating the bound amounts of a labeled folate and a known folate at various concentrations of the known folate in a system containing a predetermined amount of the labeled folate, a predetermined amount of the binder factor for the folates, and a predetermined amount of defolated test serum.

摘要翻译： 提供了用于测量血清中叶酸浓度的快速且成本较低的放射性同位素测定法。 该方法使用3H-蝶呤单谷氨酸盐，未标记的5-甲基 - 四氢叶酸和部分纯化的叶酸粘合剂，例如从猪肾提取的叶酸粘合剂。 该方法涉及在包含预定量的标记叶酸，预定量的叶酸的粘合剂因子和预定量的体系中将已标记的叶酸和已知叶酸的各种浓度的已知叶酸的结合量放射性同位素联系在一起 的脱水测试血清。

公开(公告)号：US08129383B2

公开(公告)日：2012-03-06

申请号：US11928890

申请日：2007-10-30

申请人： John Zebala ,  Barton A. Kamen

发明人： John Zebala ,  Barton A. Kamen

IPC分类号： A61K31/505

CPC分类号： A61K31/519 ,  A61K31/525 ,  Y10S514/825 ,  Y10S514/863 ,  Y10S514/886 ,  Y10S514/903

摘要： There is disclosed dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof, that achieve efficacy without concomitant toxicity. Specifically, there is disclosed a method for treating an inflammatory disorder in a patient with uninterrupted doses of aminopterin.

摘要翻译： 公开了用治疗有效量的氨基喋呤或其药学上可接受的盐治疗具有炎性病症的患者的剂型和方法，其实现功效而没有伴随的毒性。 具体地，公开了一种用于治疗患有不间断剂量的氨基蝶呤的患者的炎性疾病的方法。

公开(公告)号：US20120128703A1

公开(公告)日：2012-05-24

申请号：US13360778

申请日：2012-01-29

申请人： Barton A. Kamen ,  John Zebala

发明人： Barton A. Kamen ,  John Zebala

IPC分类号： A61K31/519 ,  A61P37/06 ,  A61P29/00

CPC分类号： A61K31/519 ,  A61K31/525 ,  Y10S514/825 ,  Y10S514/863 ,  Y10S514/886 ,  Y10S514/903

摘要： There is disclosed dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof, that achieve efficacy without concomitant toxicity. Specifically, there is disclosed a method for treating an inflammatory disorder in a patient with uninterrupted doses of aminopterin.

摘要翻译： 公开了用治疗有效量的氨基喋呤或其药学上可接受的盐治疗具有炎性病症的患者的剂型和方法，其实现功效而没有伴随的毒性。 具体地，公开了一种用于治疗患有不间断剂量的氨基蝶呤的患者的炎性疾病的方法。

公开(公告)号：US3981983A

公开(公告)日：1976-09-21

申请号：US591310

申请日：1975-06-30

申请人： J. Douglas Caston ,  Barton A. Kamen

发明人： J. Douglas Caston ,  Barton A. Kamen

IPC分类号： G01N33/53 ,  C12Q1/26 ,  G01N33/94 ,  G01N33/00 ,  A61K43/00 ,  G21H5/02

CPC分类号： G01N33/94 ,  C12Q1/26 ,  Y10S435/968 ,  Y10S435/971 ,  Y10S436/815

摘要： A radiochemical ligand binding assay for methotrexate is provided. A binder factor comprising a partially purified dihydrofolic acid reductase preparation is employed. The binder factor is conveniently prepared by homogenizing a factor containing animal organ such as liver, and extracting with isotonic saline and ammonium sulfate. A binder cofactor, NADPH.sub.2, is also employed in the binding reaction. The procedure contemplates both direct and sequential assay techniques, and it is not interfered with by vast excesses of many natural folate derivatives.

摘要翻译： 提供了甲氨蝶呤的放射化学配体结合测定法。 使用包含部分纯化的二氢叶酸还原酶制剂的粘合剂因子。 通过使含有动物器官如肝脏的因子均质并用等渗盐水和硫酸铵提取来方便地制备粘合剂因子。 粘合剂辅因子NADPH2也用于结合反应。 该方法考虑到直接和顺序的测定技术，并且不会被大量过量的许多天然叶酸衍生物所干扰。