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12 条记录 (耗时 0.026 秒)

    System and method for sealing battery separator
    1.
    发明授权
    System and method for sealing battery separator 有权
    密封电池分离器的系统和方法

    公开(公告)号：US08551642B2

    公开(公告)日：2013-10-08

    申请号：US13037972

    申请日：2011-03-01

    申请人： Adam J. Morgan ,  Ignacio Chi ,  Brian L. Schmidt ,  Benjamin J. Haasl ,  Jon Schell

    发明人： Adam J. Morgan ,  Ignacio Chi ,  Brian L. Schmidt ,  Benjamin J. Haasl ,  Jon Schell

    IPC分类号： H01M2/00

    CPC分类号： H01M2/1653 ,  H01M2/06 ,  H01M2/08 ,  H01M2/1673 ,  H01M2/361 ,  H01M2/365 ,  H01M4/405 ,  H01M4/505 ,  H01M10/058

    摘要： One embodiment of the present subject matter includes a battery having a stack of substantially planar battery electrodes, the stack including a first electrode including a first tab, and a second electrode including a second tab, with the first tab electrically connected to the second tab. The embodiment includes a first separator layer and a second separator layer sandwiching the first electrode, with the edges of the first separator layer and the second separator connected with a weld, the first separator layer and the second separator layer defining an interior space in which the first electrode is disposed, with the first tab extending outside the interior space. The embodiment includes a battery housing having electrolyte disposed therein, the housing including at least a first aperture and a feedthrough aperture; a lid conformed and sealed to the first aperture; and a feedthrough conformed and sealed to the feedthrough aperture.

    摘要翻译： 本主题的一个实施例包括具有基本上平面的电池电极的堆叠的电池，该堆叠包括包括第一突出部的第一电极和包括第二突出部的第二电极，其中第一突出部电连接到第二突出部。 该实施例包括夹着第一电极的第一隔离层和第二隔离层，第一隔板层和第二隔板的边缘与焊缝相连，第一隔离层和第二隔离层限定内部空间， 第一电极被布置，第一突出部延伸到内部空间的外部。 该实施例包括其中设置有电解质的电池壳体，该壳体至少包括第一孔和馈通孔; 盖子适合并密封到第一孔; 并且馈通符合并密封到馈通孔。

    Method and apparatus for concurrent welding and excise of battery separator
    2.
    发明授权
    Method and apparatus for concurrent welding and excise of battery separator 有权
    电池分离器同时焊接和消除的方法和装置

    公开(公告)号：US08048252B2

    公开(公告)日：2011-11-01

    申请号：US12776726

    申请日：2010-05-10

    申请人： Paul Machacek ,  Adam J. Morgan ,  Benjamin J. Haasl

    发明人： Paul Machacek ,  Adam J. Morgan ,  Benjamin J. Haasl

    IPC分类号： B32B37/00

    CPC分类号： B29C65/38 ,  B29C65/02 ,  B29C65/224 ,  B29C65/226 ,  B29C65/743 ,  B29C66/1122 ,  B29C66/433 ,  B29C66/71 ,  B29C66/7234 ,  B29C66/727 ,  B29C66/8322 ,  B29C66/9241 ,  B29C66/9261 ,  B29K2023/06 ,  B29K2023/12 ,  B29K2105/04 ,  B29K2705/00 ,  B29L2009/00 ,  B29L2031/3468 ,  H01M2/021 ,  H01M2/1673 ,  H01M2/18 ,  H01M10/058 ,  Y10T29/49108 ,  Y10T29/4911 ,  Y10T156/1054

    摘要： The present subject matter relates to a method which includes positioning a bottom and top polymeric separator sheet on a working surface, with a substantially planar battery anode disposed therebetween; applying a pressure and an electrical current to a cutting and welding tool such that top and bottom polymeric separator sheets are welded into a bag and such that the bag is excised from the top and bottom separator sheets, with the battery anode disposed in the bag; stacking the battery anode and at least one cathode into a battery stack; and disposing the battery stack into a battery case having at least one feedthrough, with a first terminal connected to the battery stack through the at least one feedthrough, and with the battery case filled with an electrolyte, wherein the protrusion is defined by laser cutting the cutting and welding tool, machining the cutting and welding tool, or photochemical etching the cutting and welding tool.

    摘要翻译： 本主题涉及一种方法，其包括将底部和顶部聚合物隔离片定位在工作表面上，其中设置有基本上平面的电池阳极; 向切割和焊接工具施加压力和电流，使得顶部和底部聚合物隔离片被焊接到袋中，并且使得袋被从顶部和底部隔离片切除，电池阳极设置在袋中; 将电池阳极和至少一个阴极堆叠到电池堆中; 以及将所述电池堆放置在具有至少一个馈通的电池壳体中，其中第一端子通过所述至少一个馈通连接到所述电池堆叠，并且所述电池壳体填充有电解质，其中所述突起通过激光切割 切割和焊接工具，加工切割和焊接工具，或光化学蚀刻切割和焊接工具。

    Lamination of Lithium Battery Elements for Implantable Medical Devices
    3.
    发明申请
    Lamination of Lithium Battery Elements for Implantable Medical Devices 审中-公开
    用于植入式医疗器械的锂电池元件的层压

    公开(公告)号：US20080221629A1

    公开(公告)日：2008-09-11

    申请号：US11684317

    申请日：2007-03-09

    申请人： Adam J. Morgan ,  Daniel J. Foster ,  Brian L. Schmidt

    发明人： Adam J. Morgan ,  Daniel J. Foster ,  Brian L. Schmidt

    IPC分类号： A61N1/02

    CPC分类号： A61N1/378 ,  H01M4/04 ,  H01M4/405 ,  H01M4/70 ,  H01M10/052 ,  H01M10/0585 ,  Y10T29/10 ,  Y10T29/49108 ,  Y10T29/53139

    摘要： A method includes the step of providing a sheet of lithium and a sheet of substrate material. The method further includes the step of pressing the sheet of lithium and the sheet of substrate material together in a die, the die having at least one surface that includes a plurality of force concentrating features configured to create regions of relatively higher pressure and regions of relatively lower pressure in at least one of the sheet of lithium and the sheet of substrate material. In another embodiment, a method includes the steps of providing a sheet of lithium material and a substrate material, and applying force to the sheet of lithium and the sheet of substrate material to form a plurality of protrusions on at least one of the sheet of lithium and the sheet of substrate material. The method includes the further step of pressing at least a portion of the sheet of lithium to the substrate material with sufficient force to at least partially deform the protrusions.

    摘要翻译： 一种方法包括提供一片锂片和一片基片材料的步骤。 该方法还包括将模具中的锂片和基片材料压在一起的步骤，所述模具具有至少一个表面，所述至少一个表面包括多个强制聚焦特征，所述力集中特征被构造成产生相对较高压力的区域和相对较大的区域 在锂片和基片材料片中的至少一个中降低压力。 在另一个实施方案中，一种方法包括以下步骤：提供锂材料片和基底材料片，并且将力施加到锂片和基片材料片上，以在锂片中的至少一个上形成多个突起 和基片材料片。 该方法包括进一步的步骤，用足够的力将片状锂的至少一部分压到衬底材料上，以至少部分地使突起变形。

    4-hydroxybutyric acid analogs
    5.
    发明授权
    4-hydroxybutyric acid analogs 有权
    4-羟基丁酸类似物

    公开(公告)号：US08759394B2

    公开(公告)日：2014-06-24

    申请号：US13372989

    申请日：2012-02-14

    申请人： Roger D. Tung ,  Adam J. Morgan

    发明人： Roger D. Tung ,  Adam J. Morgan

    IPC分类号： A01N37/00 ,  A61K31/19

    CPC分类号： C07C59/115 ,  A61K31/19 ,  A61K31/22 ,  A61K31/225 ,  A61K45/06 ,  C07B59/001 ,  C07B2200/05 ,  C07C59/01 ,  C07C59/125 ,  C07C69/67 ,  C07C69/675 ,  C07C69/708

    摘要： This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.

    摘要翻译： 本发明涉及4-羟基丁酸的新衍生物及其前体药物及其药学上可接受的盐。 本发明还提供了包含本发明化合物的药物组合物以及这些组合物在治疗发作性睡病，纤维肌痛，其它障碍或通过改善夜间睡眠或通过施用羟酸钠有益治疗的病症的方法中的用途。

    Kinase mimic catalysts for asymmetric synthesis of phosphorylated inositols and cycloalkanols
    6.
    发明授权
    Kinase mimic catalysts for asymmetric synthesis of phosphorylated inositols and cycloalkanols 失效
    用于不对称合成磷酸化肌醇和环烷醇的激酶模拟催化剂

    公开(公告)号：US07037691B2

    公开(公告)日：2006-05-02

    申请号：US10187208

    申请日：2002-07-01

    申请人： Scott J. Miller ,  Bianca Sculimbrene ,  Adam J. Morgan

    发明人： Scott J. Miller ,  Bianca Sculimbrene ,  Adam J. Morgan

    IPC分类号： C12P9/00 ,  C07K2/00

    CPC分类号： C07K7/06 ,  C07K7/02

    摘要： The present invention provides peptide-based phosphorylation catalysts (PBPC's) for the asymmetric monophosphorylation of cyclitols, particularly myo-inositols. The PBPC's of the invention effect a regio and enantioselective phosphorylation of a myo-inositol in a manner analogous to enzymatic kinases, thereby functioning as effective “kinase mimics.” Although orders of magnitude less complex in terms of structure than macromolecular proteins, the PBPC's of the invention control product formation with high enantioselectivity (>98% ee). The synthetic (+)-myo-inositol-1-phosphate is optically and spectroscopically equivalent to naturally occuring compound. The ability of the low molecular weight PBPC's of the present invention to mimic stereoselective enzymes represents a powerful approach toward catalytic asymmetric synthesis of biologically important molecules, and for mechanistic modeling of biochemical transformations to enable their use in drug applications.

    摘要翻译： 本发明提供了用于环醇，特别是肌醇的不对称单磷酸化的基于肽的磷酸化催化剂（PBPC）。 本发明的PBPC以与酶促激酶类似的方式影响肌醇的区域和对映选择性磷酸化，从而起到有效的“激酶模拟物”的作用。 虽然结构方面的数量比大分子蛋白质数量级小，本发明的PBPC控制了高对映选择性（> 98％ee）的产物形成。 合成的（+） - 肌醇-1-磷酸酯在光学和光谱上等同于天然存在的化合物。 本发明的低分子量PBPC模拟立体选择性酶的能力代表了对生物重要分子的催化不对称合成以及用于生物化学转化的机械建模使其能够用于药物应用的强大方法。

    Deuterated CFTR potentiators
    7.
    发明授权
    Deuterated CFTR potentiators 有权
    氘代CFTR电位器

    公开(公告)号：US08865902B2

    公开(公告)日：2014-10-21

    申请号：US14082843

    申请日：2013-11-18

    申请人： Adam J. Morgan

    发明人： Adam J. Morgan

    IPC分类号： C07D215/00 ,  A61K31/47 ,  C07D215/56

    CPC分类号： C07D215/56 ,  C07B59/002 ,  C07B2200/05

    摘要： This invention relates to compounds of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a CFTR potentiator.

    摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐。 本发明还提供包含本发明化合物的组合物以及这些组合物在治疗通过施用CFTR增效剂有益治疗的疾病和病症的方法中的用途。

    DEUTERATED CFTR POTENTIATORS
    9.
    发明申请
    DEUTERATED CFTR POTENTIATORS 有权
    去除CFTR电位器

    公开(公告)号：US20140073667A1

    公开(公告)日：2014-03-13

    申请号：US14082843

    申请日：2013-11-18

    申请人： Adam J. Morgan

    发明人： Adam J. Morgan

    IPC分类号： C07D215/56

    CPC分类号： C07D215/56 ,  C07B59/002 ,  C07B2200/05

    摘要： This invention relates to compounds of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a CFTR potentiator.

    摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐。 本发明还提供包含本发明化合物的组合物以及这些组合物在治疗通过施用CFTR增效剂有益治疗的疾病和病症的方法中的用途。

    SYSTEM AND METHOD FOR DIE CUTTING MANIFOLD INCLUDING A LUBRICATION CHANNEL
    10.
    发明申请
    SYSTEM AND METHOD FOR DIE CUTTING MANIFOLD INCLUDING A LUBRICATION CHANNEL 审中-公开
    用于切割包括润滑通道的切割系统和方法

    公开(公告)号：US20080053185A1

    公开(公告)日：2008-03-06

    申请号：US11468666

    申请日：2006-08-30

    申请人： Adam J. Morgan ,  James P. Rohl

    发明人： Adam J. Morgan ,  James P. Rohl

    IPC分类号： B21J11/00

    CPC分类号： B21D37/18 ,  B21D28/14

    摘要： One embodiment of the present subject matter includes an assembly. The assembly includes a stripper plate having a stripper plate face and defining and elongate opening extending through the stripper plate face and into the stripper plate. A punch of the assembly is slidably disposed in the elongate opening, the punch having a punch profile shaped to conform to the elongate opening. The assembly includes a die in alignment with the stripper plate, the die having a die face opposed to the stripper plate face, the face defining a die opening which is substantially coextensive with the elongate opening of the stripper plate, the die defining a plurality of wetting lumens extending through the die, with each lumen terminating in the die face near the die opening, each of the lumens adapted to dispense a lubricant to the die face and along the die opening.

    摘要翻译： 本主题的一个实施例包括组件。 组件包括具有剥离板面的剥离板，并且限定和延伸穿过剥离板表面并进入剥离板的细长开口。 组件的冲头可滑动地设置在细长开口中，冲头具有成形为符合细长开口的冲头轮廓。 组件包括与剥离板对准的模具，模具具有与剥离板面相对的模具面，该表面限定与剥离板的细长开口基本共同延伸的模具开口，模具限定多个 润湿流过模具的流明，其中每个管腔终止在模具开口附近的模具表面中，每个腔体适于将润滑剂分配到模具表面并沿着模具开口。