-
1.
公开(公告)号:US07820704B2
公开(公告)日:2010-10-26
申请号:US11110499
申请日:2005-04-20
申请人: Adnan M. M. Mjalli , Bapu R. Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty N. Arimilli , Robert C. Andrews , Samuel Victory , Ye E. Tian
发明人: Adnan M. M. Mjalli , Bapu R. Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty N. Arimilli , Robert C. Andrews , Samuel Victory , Ye E. Tian
IPC分类号: A61K31/427 , A61K31/381 , C07D277/38 , C07D409/12
CPC分类号: C07D277/52 , C07D239/42 , C07D277/26 , C07D277/42 , C07D277/50 , C07D277/56 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要: The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
摘要翻译: 本发明提供式(I)的取代杂芳基衍生物,其制备方法,包含式(I)化合物的药物组合物,以及用于治疗人或动物病症的方法。 本发明的化合物可用作AgRP对黑皮质素受体的作用抑制剂,因此可用于治疗,治疗,控制或辅助治疗可能对黑皮质素受体的调节(包括肥胖症 - 相关疾病。