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1.发明申请Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors 失效苯并恶唑衍生物，组合物和使用方法作为极光激酶抑制剂公开(公告)号：US20100152170A1
公开(公告)日：2010-06-17
申请号：US12703604
申请日：2010-02-10
Applicant: Adnan M.M. Mjalli , Brian S. Grella , Govindan Subramanian , Murty N. Arimilli , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Xiaochuan Guo , Jeff Zhu
Inventor： Adnan M.M. Mjalli , Brian S. Grella , Govindan Subramanian , Murty N. Arimilli , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Xiaochuan Guo , Jeff Zhu
IPC: A61K31/551 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K31/4439 , A61K31/428 , A61K31/4184 , A61P35/00 , A61P35/02
CPC classification number: C07D417/14 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04
Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.
Abstract translation: 本发明涉及治疗癌症的化合物和方法。 本发明提供抑制极光激酶的化合物，包含抑制极光激酶的化合物的药物组合物，以及使用本发明化合物或包含本发明化合物的药物组合物治疗癌症的方法。
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公开(公告)号：US20070054897A1
公开(公告)日：2007-03-08
申请号：US11453330
申请日：2006-06-14
Applicant: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Michael Ankersen , Jane Lundbeck , Marit Kristiansen , Maria Valcarce-Lopez , Dharma Polisetti , Govindan Subramanian , Robert Andrews , Daniel Christen , Jeremy Cooper , Kalpathy Santhosh
Inventor： Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Michael Ankersen , Jane Lundbeck , Marit Kristiansen , Maria Valcarce-Lopez , Dharma Polisetti , Govindan Subramanian , Robert Andrews , Daniel Christen , Jeremy Cooper , Kalpathy Santhosh
IPC: A61K31/551 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/428 , C07D417/02
CPC classification number: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
Abstract: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
Abstract translation: 本发明涉及作为葡萄糖激酶活化剂的式（I）化合物，因此可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。
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公开(公告)号：US20110301158A1
公开(公告)日：2011-12-08
申请号：US13209565
申请日：2011-08-15
Applicant: Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Maria Carmen Valcarce-Lopez , Niels Blume , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M.M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
Inventor： Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Maria Carmen Valcarce-Lopez , Niels Blume , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M.M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
IPC: A61K31/5355 , A61P3/10 , A61K31/497 , A61K31/426 , A61K31/433
CPC classification number: C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
Abstract: This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
Abstract translation: 本发明涉及作为葡萄糖激酶活化剂的芳基羰基衍生物，其可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。
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公开(公告)号：US08063081B2
公开(公告)日：2011-11-22
申请号：US11981997
申请日：2007-10-31
Applicant: Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Maria Carmen Valcarce Lopez , Niels Blume , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M. M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
Inventor： Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Maria Carmen Valcarce Lopez , Niels Blume , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M. M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
IPC: A61K31/425 , A61K31/44 , C07D277/04 , C07D211/72
CPC classification number: C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
Abstract: This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
Abstract translation: 本发明涉及作为葡萄糖激酶活化剂的芳基羰基衍生物，其可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。
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5.发明授权Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors 有权苯并唑衍生物，组合物和用作极光激酶抑制剂的方法公开(公告)号：US07820821B2
公开(公告)日：2010-10-26
申请号：US11704431
申请日：2007-02-09
Applicant: Adnan M. M. Mjalli , Brian S. Grella , Govindan Subramanian , Murty N. Arimilli , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Xiaochuan Guo , Jeff Zhu
Inventor： Adnan M. M. Mjalli , Brian S. Grella , Govindan Subramanian , Murty N. Arimilli , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Xiaochuan Guo , Jeff Zhu
IPC: A61K31/496 , C07D401/14 , C07D403/14
CPC classification number: C07D417/14 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04
Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.
Abstract translation: 本发明涉及治疗癌症的化合物和方法。 本发明提供抑制极光激酶的化合物，包含抑制极光激酶的化合物的药物组合物，以及使用本发明化合物或包含本发明化合物的药物组合物治疗癌症的方法。
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Patent Agency Ranking
6.发明授权N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes 失效N-杂芳基吲哚羧酰胺及其类似物，用作糖尿病治疗中的葡糖激酶活化剂公开(公告)号：US07812043B2
公开(公告)日：2010-10-12
申请号：US11439820
申请日：2006-05-24
Applicant: Jesper F Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
Inventor： Jesper F Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
IPC: A61K31/427 , C07D417/12
CPC classification number: C07D401/12 , C07D403/12 , C07D417/12 , C07D491/04
Abstract: This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The compounds are of the general formula (I) wherein A and B are further defined in the application.
Abstract translation: 本发明涉及作为葡萄糖激酶活化剂的化合物，因此可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。 所述化合物具有通式（I），其中A和B在本申请中进一步定义。
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公开(公告)号：US07598391B2
公开(公告)日：2009-10-06
申请号：US11453330
申请日：2006-06-14
Applicant: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
Inventor： Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
IPC: C07D277/26
CPC classification number: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
Abstract: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
Abstract translation: 本发明涉及作为葡萄糖激酶活化剂的式（I）化合物，因此可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。
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公开(公告)号：US07384967B2
公开(公告)日：2008-06-10
申请号：US10679887
申请日：2003-10-06
Applicant: Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M. M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
Inventor： Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M. M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
IPC: A61K31/425 , A61K31/44 , C07D277/04 , C07D211/72
CPC classification number: C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
Abstract: This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
Abstract translation: 本发明涉及作为葡萄糖激酶活化剂的芳基羰基衍生物，其可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。
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公开(公告)号：US20080119454A1
公开(公告)日：2008-05-22
申请号：US11981997
申请日：2007-10-31
Applicant: Dharma Polisetti , Janos Kodra , Jesper Lau , Paw Bloch , Maria Valcarce-Lopez , Niels Blume , Mustafa Guzel , Kalpathy Santhosh , Adnan Mjalli , Robert Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
Inventor： Dharma Polisetti , Janos Kodra , Jesper Lau , Paw Bloch , Maria Valcarce-Lopez , Niels Blume , Mustafa Guzel , Kalpathy Santhosh , Adnan Mjalli , Robert Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
IPC: A61K31/55 , A61K31/427 , A61K31/454 , C07D417/02
CPC classification number: C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
Abstract: This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
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公开(公告)号：US20050261294A1
公开(公告)日：2005-11-24
申请号：US11110499
申请日：2005-04-20
Applicant: Adnan Mjalli , Bapu Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty Arimilli , Robert Andrews , Samuel Victory , Ye Tian
Inventor： Adnan Mjalli , Bapu Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty Arimilli , Robert Andrews , Samuel Victory , Ye Tian
IPC: A61K31/426 , A61K31/505 , A61K31/53 , C07D239/42 , C07D277/42 , C07D277/46 , C07D277/52 , C07D277/56 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14
CPC classification number: C07D277/52 , C07D239/42 , C07D277/26 , C07D277/42 , C07D277/50 , C07D277/56 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D417/14
Abstract: The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
Abstract translation: 本发明提供式（I）的取代杂芳基衍生物，其制备方法，包含式（I）化合物的药物组合物，以及用于治疗人或动物病症的方法。 本发明的化合物可用作AgRP对黑皮质素受体的作用抑制剂，因此可用于治疗，治疗，控制或辅助治疗可能对黑皮质素受体的调节（包括肥胖症 - 相关疾病。
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