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公开(公告)号：US08715735B2
公开(公告)日：2014-05-06
申请号：US11076022
申请日：2005-03-10
申请人： Adrian Funke , Torsten Wagner , Ralph Lipp
发明人： Adrian Funke , Torsten Wagner , Ralph Lipp
CPC分类号： A61K9/08 , A61K9/143 , A61K31/565 , A61K31/585 , A61K47/10 , A61K47/14 , A61K47/44
摘要： Methods for improving solubility and bioavailability of lipophilic compounds are described. Particularly, described are stabilized supersaturated solid solutions, particularly in power from, of lipophilic drugs, such as steroidal molecules.
摘要翻译： 描述了改善亲脂性化合物的溶解性和生物利用度的方法。 特别地，描述了稳定的过饱和固体溶液，特别是来自亲脂性药物如甾类分子的功能。
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公开(公告)号：US20050207990A1
公开(公告)日：2005-09-22
申请号：US11076022
申请日：2005-03-10
申请人： Adrian Funke , Torsten Wagner , Ralph Lipp
发明人： Adrian Funke , Torsten Wagner , Ralph Lipp
IPC分类号： A61K9/08 , A61K9/14 , A61K31/565 , A61K31/585 , A61K47/10 , A61K47/14 , A61K47/44 , A61L9/04 , A61K31/56
CPC分类号： A61K9/08 , A61K9/143 , A61K31/565 , A61K31/585 , A61K47/10 , A61K47/14 , A61K47/44
摘要： Methods for improving solubility and bioavailability of lipophilic compounds are described. Particularly, described are stabilized superstaturated solid solutions, particularly in power form, of lipophilic drugs, such as steroidal molecules.
摘要翻译： 描述了改善亲脂性化合物的溶解性和生物利用度的方法。 特别地，描述了稳定的超饱和固体溶液，特别是功能形式的亲脂性药物，例如类固醇分子。
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公开(公告)号：US08022053B2
公开(公告)日：2011-09-20
申请号：US11262952
申请日：2005-11-01
IPC分类号： A61K31/56
CPC分类号： A61K31/56 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2813 , A61K9/284 , A61K9/2866
摘要： The present invention relates to oral solid dosage forms containing a very low dose of estradiol. The dosage forms are formulated in a manner so as to avoid degradation of the estradiol and to minimise the content of polyvinylpyrrolidone, while still achieving similar fast dissolution of the estradiol. The dosage forms are useful in preventing or treating a physical condition in a woman caused by insufficient endogenous levels of estradiol.
摘要翻译： 本发明涉及含有非常低剂量的雌二醇的口服固体剂型。 剂型配制以避免雌二醇降解并使聚乙烯吡咯烷酮的含量最小化，同时仍然实现雌二醇的类似的快速溶解。 剂型可用于预防或治疗由内源性雌二醇不足引起的妇女的身体状况。
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![Immediate-release and high-drug-load pharmaceutical formulations of non-micronised (4-chlorophenyl)[4-(4-pyridylmethyl)phthalazin-1-yl] and salts thereof](/abs-image/US/2007/03/15/US20070059359A1/abs.jpg.150x150.jpg)
4.发明申请Immediate-release and high-drug-load pharmaceutical formulations of non-micronised (4-chlorophenyl)[4-(4-pyridylmethyl)phthalazin-1-yl] and salts thereof 审中-公开非微粉化（4-氯苯基）[4-（4-吡啶基甲基）二氮杂萘-1-基]及其盐的立即释放和高药物负载药物制剂公开(公告)号：US20070059359A1
公开(公告)日：2007-03-15
申请号：US11448136
申请日：2006-06-07
申请人： Thomas Backensfeld , Adrian Funke , Kai Juergens , Kai Thode , Torsten Wagner
发明人： Thomas Backensfeld , Adrian Funke , Kai Juergens , Kai Thode , Torsten Wagner
IPC分类号： A61K9/20 , A61K31/502
CPC分类号： A61K9/2018 , A61K9/1623 , A61K9/2866 , A61K31/502
摘要： The invention relates to immediate-release and high-drug-load solid pharmaceutical formulations comprising non-micronized (4-chlorophenyl)[4-(4-pyridylmethyl)-phthalazin-1-yl] as well as pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及包含非微粉化（4-氯苯基）[4-（4-吡啶基甲基） - 酞嗪-1-基]的立即释放和高药物负载的固体药物制剂及其药学上可接受的盐。
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公开(公告)号：US20060111334A1
公开(公告)日：2006-05-25
申请号：US11262952
申请日：2005-11-01
IPC分类号： A61K31/56
CPC分类号： A61K31/56 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2813 , A61K9/284 , A61K9/2866
摘要： The present invention relates to oral solid dosage forms containing a very low dose of estradiol. The dosage forms are formulated in a manner so as to avoid degradation of the estradiol and to minimise the content of polyvinylpyrrolidone, while still achieving similar fast dissolution of the estradiol. The dosage forms are useful in preventing or treating a physical condition in a woman caused by insufficient endogenous levels of estradiol.
摘要翻译： 本发明涉及含有非常低剂量的雌二醇的口服固体剂型。 剂型配制以避免雌二醇降解并使聚乙烯吡咯烷酮的含量最小化，同时仍然实现雌二醇的类似的快速溶解。 剂型可用于预防或治疗由内源性雌二醇不足引起的妇女的身体状况。
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公开(公告)号：US20050220825A1
公开(公告)日：2005-10-06
申请号：US11076034
申请日：2005-03-10
申请人： Adrian Funke , Torsten Wagner
发明人： Adrian Funke , Torsten Wagner
CPC分类号： A61K9/145 , A61K9/006 , A61K9/1075 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/2077 , A61K9/4808 , A61K9/4858 , A61K9/7007
摘要： Described are pharmaceutical compositions comprising at least one steroidal drug such as a progestin (e.g. drospirenone, progesterone, eplerenone, etonogestrel) and/or an estrogen (estradiol and esters thereof) in molecularly dispersed form. The composition comprises a steroidal drug, preferably drospirenone, which is present in the composition in a non-particulate form. Preferably, the drug is present in a dissolved state in the excipient. The molecularly dispersed drug will be released very fast as dissolution takes place instantly when the dosage unit has disintegrated. Also described are methods for preparing the pharmaceutical compositions and methods of using the compositions.
摘要翻译： 描述了包含分子分散形式的至少一种类固醇药物如孕激素（例如屈螺酮，孕酮，依普利酮，依托孕烯）和/或雌激素（雌二醇及其酯）的药物组合物。 组合物包含甾体药物，优选屈螺酮，其以非微粒形式存在于组合物中。 优选地，药物以赋形剂中的溶解状态存在。 分散分散的药物将被释放得非常快，因为当剂量单位分解时立即发生溶解。 还描述了制备药物组合物的方法和使用该组合物的方法。
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公开(公告)号：US06512139B1
公开(公告)日：2003-01-28
申请号：US09720134
申请日：2001-03-07
申请人： Torsten Wagner , Martin Wessel , Ralph Lipp , Bernd Iffert , Heinrich Michel , Jürgen Westermann , Helmut Dahl , Werner Skuballa
发明人： Torsten Wagner , Martin Wessel , Ralph Lipp , Bernd Iffert , Heinrich Michel , Jürgen Westermann , Helmut Dahl , Werner Skuballa
IPC分类号： C07C40500
CPC分类号： A61K31/5585 , A61K9/1694 , A61K31/5575 , C08B37/0015
摘要： The invention relates to the use of an oxidation inhibitor, i.e. active carbon, for ambient air in industrial manufacturing, especially in the processing of prostane derivatives, whereby the oxidation inhibitor removes ozone from the process air before contact with said prostane derivatives. The concentration of decomposition products is reduced.
摘要翻译： 本发明涉及在工业制造中使用氧化抑制剂（即活性炭）用于环境空气，特别是在前列腺衍生物的加工中，其中氧化抑制剂在与所述前列腺衍生物接触之前从工艺空气中除去臭氧。 分解产物的浓度降低。
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8.发明申请Pharmaceutical form with sustained pH-independent active ingredient release for active ingredients having strong pH-dependent solubility 审中-公开具有持续的pH依赖性活性成分释放的具有强pH依赖性溶解性的活性成分的药物形式公开(公告)号：US20070087056A1
公开(公告)日：2007-04-19
申请号：US11500501
申请日：2006-08-08
申请人： Claudia Guthmann , Heiko Kranz , Ralph Lipp , Torsten Wagner
发明人： Claudia Guthmann , Heiko Kranz , Ralph Lipp , Torsten Wagner
IPC分类号： A61K9/24
CPC分类号： A61K9/0004
摘要： Solid pharmaceutical formulation for a sustained pH-independent active ingredient release comprising at least one layer of one or more water-insoluble polymers, at least one layer of one or more pH-dependently water-soluble polymers and an active ingredient-containing core, having strong pH-dependent water solubility and comprises at least one osmagent.
摘要翻译： 用于持续的pH非依赖性活性成分释放的固体药物制剂，其包含至少一层一种或多种水不溶性聚合物，至少一层一种或多种pH依赖性水溶性聚合物和含活性成分的核心，其具有 强的pH依赖性水溶性，并且包含至少一种渗透剂。
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公开(公告)号：US06723372B1
公开(公告)日：2004-04-20
申请号：US09622811
申请日：2000-08-23
申请人： Torsten Wagner
发明人： Torsten Wagner
IPC分类号： B05D102
CPC分类号： A61K31/5575 , A61K9/5026 , A61K9/5089 , A61K31/5585
摘要： A process for the production of encased, spherical granular grains comprising spraying grains which consist of a prostane derivative and a cyclodextrin vehicle, forming together a prostane-cyclodextrine-clathrate, with an aqueous polymer dispersion of ethyl cellulose and/or poly(methyl)acrylic acid ester in a fluidized or boiling bed is disclosed. The polymer dispersion is applied in a thickness equivalent to 1-5% (w/w) of the total mass of the encased grains. The coated grains are cured for at least 24 hours. Grains produced according to this method have a pharmaceutical active ingredient release profile which remains unchanged over the storage time.
摘要翻译： 包括球形颗粒的生产方法，包括将由前列腺衍生物和环糊精载体组成的颗粒喷雾，由前列腺 - 环糊精包合物与乙基纤维素和/或聚（甲基）丙烯酸酯的水性聚合物分散体 公开了在流化床或沸腾床中的酸酯。 聚合物分散体的施加厚度相当于包裹颗粒总质量的1-5％（w / w）。 涂覆的颗粒固化至少24小时。 根据该方法生产的谷物具有在储存时间内保持不变的药物活性成分释放特征。
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公开(公告)号：US06474704B1
公开(公告)日：2002-11-05
申请号：US09367987
申请日：1999-11-23
申请人： Klaus Rathmann , Torsten Wagner
发明人： Klaus Rathmann , Torsten Wagner
IPC分类号： E05C306
CPC分类号： E05B81/14 , E05B77/02 , Y10S292/23 , Y10T292/1047 , Y10T292/1082
摘要： Lock for a movable arrangement, such as a door, rear flap or the like of a vehicle, having an actuating drive (10) for the drive of a component, in particular a detent pawl (4), of the lock, wherein, for the direct or indirect drive of the component, a further actuating drive (13) for the component is provided.
摘要翻译： 锁定用于车辆的可移动装置，例如门，后翼片等，具有用于驱动锁的部件，特别是止动爪（4）的致动驱动器（10），其中，用于 提供了部件的直接或间接驱动，用于部件的另外的致动驱动器（13）。
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