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    Assay systems and methods for detecting molecules that interact with SK2 channels
    2.
    发明申请
    Assay systems and methods for detecting molecules that interact with SK2 channels 审中-公开
    用于检测与SK2通道相互作用的分子的测定系统和方法

    公开(公告)号：US20050250090A1

    公开(公告)日：2005-11-10

    申请号：US10975798

    申请日：2004-10-28

    申请人： Edward Kaftan ,  Adrienne Dubin ,  Sandra Chaplan

    发明人： Edward Kaftan ,  Adrienne Dubin ,  Sandra Chaplan

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/68

    CPC分类号： G01N33/6872 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/5041 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2500/00 ,  G01N2800/2842

    摘要： The invention provides methods including steps of: providing cells capable of expressing SK2; contacting the cells with a test molecule; obtaining information indicative of cellular SK2 expression to obtain an SK2 Expression Value; comparing the SK2 Expression Value with a control SK2 Expression Value; and identifying a test molecule that causes the cells to display an SK2 Expression Value that is different from the control SK2 Expression Value. Also provided are methods including steps of: providing a sample comprising an SK2 channel; contacting the sample with a test molecule; obtaining information indicative of SK2 channel activity in the sample to obtain an SK2 Channel Activity Value; comparing the SK2 Channel Activity Value with a control Channel Activity Value; and identifying a test molecule that causes the SK2 Channel Activity Value to be different from the control Channel Activity Value. Methods of identifying a molecule useful for treating neuropathic pain are also described.

    摘要翻译： 本发明提供了包括以下步骤的方法：提供能够表达SK2的细胞; 使细胞与测试分子接触; 获得指示细胞SK2表达的信息以获得SK2表达值; 将SK2表达值与对照SK2表达值进行比较; 并鉴定导致细胞显示不同于对照SK2表达值的SK2表达值的测试分子。 还提供了包括以下步骤的方法：提供包含SK2通道的样品; 使样品与测试分子接触; 获取指示样品中SK2通道活性的信息以获得SK2通道活性值; 将SK2频道活动值与控制频道活动值进行比较; 并识别导致SK2通道活性值与控制通道活性值不同的测试分子。 还描述了鉴定用于治疗神经性疼痛的分子的方法。

    ASSAY SYSTEMS AND METHODS FOR DETECTING MOLECULES THAT INTERACT WITH SK2 CHANNELS
    4.
    发明申请
    ASSAY SYSTEMS AND METHODS FOR DETECTING MOLECULES THAT INTERACT WITH SK2 CHANNELS 审中-公开
    用于检测与SK2通道相互影响的分子的测定系统和方法

    公开(公告)号：US20080268439A1

    公开(公告)日：2008-10-30

    申请号：US11739789

    申请日：2007-04-25

    申请人： Edward Kaftan ,  Adrienne Elizabeth Dubin ,  Sandra R. Chaplan

    发明人： Edward Kaftan ,  Adrienne Elizabeth Dubin ,  Sandra R. Chaplan

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/5008 ,  G01N33/6872 ,  G01N2800/2842

    摘要： The invention provides methods including steps of: providing cells capable of expressing SK2; contacting the cells with a test molecule; obtaining information indicative of cellular SK2 expression to obtain an SK2 Expression Value; comparing the SK2 Expression Value with a control SK2 Expression Value; and identifying a test molecule that causes the cells to display an SK2 Expression Value that is different from the control SK2 Expression Value. Also provided are methods including steps of: providing a sample comprising an SK2 channel; contacting the sample with a test molecule; obtaining information indicative of SK2 channel activity in the sample to obtain an SK2 Channel Activity Value; comparing the SK2 Channel Activity Value with a control Channel Activity Value; and identifying a test molecule that causes the SK2 Channel Activity Value to be different from the control Channel Activity Value. Methods of identifying a molecule useful for treating neuropathic pain are also described.

    摘要翻译： 本发明提供了包括以下步骤的方法：提供能够表达SK2的细胞; 使细胞与测试分子接触; 获得指示细胞SK2表达的信息以获得SK2表达值; 将SK2表达值与对照SK2表达值进行比较; 并鉴定导致细胞显示不同于对照SK2表达值的SK2表达值的测试分子。 还提供了包括以下步骤的方法：提供包含SK2通道的样品; 使样品与测试分子接触; 获取指示样品中SK2通道活性的信息以获得SK2通道活性值; 将SK2频道活动值与控制频道活动值进行比较; 并识别导致SK2通道活性值与控制通道活性值不同的测试分子。 还描述了鉴定用于治疗神经性疼痛的分子的方法。