公开(公告)号：US20020009535A1

公开(公告)日：2002-01-24

申请号：US09827977

申请日：2001-04-06

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Eugene T. Michal ,  Christopher J. Buchko ,  Deborah L. Kilpatrick ,  Stephen J. Bigus

IPC: A61L002/00 ,  B05D003/00 ,  A61M029/00

CPC classification number: A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L2420/08 ,  A61M2025/0056 ,  Y10S623/926 ,  Y10T428/31511 ,  Y10T428/31536 ,  Y10T428/31609 ,  Y10T428/31721 ,  Y10T428/31855 ,  Y10T428/31942 ,  C08L89/00

Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a top coat having a therapeutic, diagnostic or hydrophilic agent, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of an agent, a grafting component, and salt. In one embodiment, the therapeutic agent is superoxide dismutase or a superoxide dismutase mimic. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device such as a stent coated with a polymeric primer or without a primer.

Abstract translation: 在体外医疗装置上提供治疗性，诊断性或润滑性的亲水性涂层的方法以及由此制造的涂覆装置，其中涂层是耐用的。 在一个实施方案中，涂层包含聚合底涂层和具有治疗性，诊断性或亲水性试剂的面漆，其中底涂层具有结合顶部涂层的结合成分，和接合组分，其结合粘合成分和 遵守设备。 在另一个实施方案中，涂层包含试剂，接枝组分和盐的共混物。 在一个实施方案中，治疗剂是超氧化物歧化酶或超氧化物歧化酶模拟物。 本发明的涂层可以应用于具有聚合物表面的医疗装置，例如聚合物导管，或金属装置，例如涂覆有聚合物底漆或不含底漆的支架。