公开(公告)号：US20020009535A1

公开(公告)日：2002-01-24

申请号：US09827977

申请日：2001-04-06

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Eugene T. Michal ,  Christopher J. Buchko ,  Deborah L. Kilpatrick ,  Stephen J. Bigus

IPC: A61L002/00 ,  B05D003/00 ,  A61M029/00

CPC classification number: A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L2420/08 ,  A61M2025/0056 ,  Y10S623/926 ,  Y10T428/31511 ,  Y10T428/31536 ,  Y10T428/31609 ,  Y10T428/31721 ,  Y10T428/31855 ,  Y10T428/31942 ,  C08L89/00

Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a top coat having a therapeutic, diagnostic or hydrophilic agent, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of an agent, a grafting component, and salt. In one embodiment, the therapeutic agent is superoxide dismutase or a superoxide dismutase mimic. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device such as a stent coated with a polymeric primer or without a primer.

Abstract translation: 在体外医疗装置上提供治疗性，诊断性或润滑性的亲水性涂层的方法以及由此制造的涂覆装置，其中涂层是耐用的。 在一个实施方案中，涂层包含聚合底涂层和具有治疗性，诊断性或亲水性试剂的面漆，其中底涂层具有结合顶部涂层的结合成分，和接合组分，其结合粘合成分和 遵守设备。 在另一个实施方案中，涂层包含试剂，接枝组分和盐的共混物。 在一个实施方案中，治疗剂是超氧化物歧化酶或超氧化物歧化酶模拟物。 本发明的涂层可以应用于具有聚合物表面的医疗装置，例如聚合物导管，或金属装置，例如涂覆有聚合物底漆或不含底漆的支架。

公开(公告)号：US20020002353A1

公开(公告)日：2002-01-03

申请号：US09915413

申请日：2001-07-25

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Eugene T. Michal ,  Christopher J. Buchko ,  Stephen J. Bigus

IPC: A61M005/32 ,  B05D003/00 ,  A61F002/06 ,  A61M025/00

CPC classification number: A61L31/10 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L2420/02 ,  A61L2420/08 ,  A61M2025/0056 ,  C08L89/00

Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.

Abstract translation: 在体外医疗装置上提供治疗性，诊断性或润滑性的亲水性涂层的方法以及由此制造的涂覆装置，其中涂层是耐用的。 在一个实施方案中，涂层包含聚合的基底涂层和治疗性，诊断性或亲水性顶涂层，其中底涂层具有结合顶部涂层的结合成分，和接合组分，其结合粘合成分并粘附于 设备。 在另一个实施方案中，涂层包含亲水化合物，接枝组分和盐的共混物，其中聚合的接枝组分含有未交联的结构域。 本发明的涂层可以应用于具有聚合物表面的医疗装置，例如聚合物导管，或涂覆有聚合物底漆或无底漆的金属装置或支架。

公开(公告)号：US20020187288A1

公开(公告)日：2002-12-12

申请号：US09879023

申请日：2001-06-11

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Florencia Lim ,  Christopher J. Buchko ,  Ashok A. Shah ,  Murthy V. Simhambhatla

IPC: B32B001/08

CPC classification number: A61L31/146 ,  A61F2/07 ,  A61F2002/072 ,  A61L27/18 ,  A61L27/56 ,  A61L29/06 ,  A61L29/146 ,  A61L31/06 ,  Y10T428/1334 ,  Y10T428/139 ,  C08L75/04

Abstract: A medical device, and particularly an intracorporeal device for therapeutic or diagnostic use, comprising a silicone polyurethane. One embodiment of the invention is a medical device having a body formed of melt process extruded, porous silicone polyurethane material. In a method of the invention, the silicone polyurethane is combined with a porogen and then melt process extruded into a desired shape such as a tubular body. The porogen is then extracted from the extrudate, to form the extruded, melt processed, porous silicone polyurethane tubular body. The medical device, such as a stent cover, vascular graft, or catheter balloon, formed of the silicone polyurethane has excellent biostability, strength, and flexibility.

Abstract translation: 医疗装置，特别是用于治疗或诊断用途的体内器械，其包含硅氧烷聚氨酯。 本发明的一个实施方案是具有由熔融加工挤出的多孔硅氧烷聚氨酯材料形成的主体的医疗装置。 在本发明的方法中，将硅氧烷聚氨酯与致孔剂组合，然后熔融加工成挤出成所需形状如管状体。 然后从挤出物中提取致孔剂，以形成挤出的熔融加工的多孔硅氧烷聚氨酯管体。 由硅氧烷聚氨酯形成的医疗装置，例如支架盖，血管移植物或导管球囊具有优异的生物稳定性，强度和柔韧性。