公开(公告)号：US09051418B2

公开(公告)日：2015-06-09

申请号：US14149493

申请日：2014-01-07

Applicant: Agency for Science, Technology and Research

Inventor： Karthikeyan Narayanan ,  Andrew Chwee Aun Wan ,  Jackie Y. Ying ,  Nandanan Erathodiyil

IPC: A61K31/765 ,  C08G65/00 ,  A61K31/08 ,  A61K31/16 ,  A61K31/69 ,  C07C235/08 ,  C07H15/08 ,  G01N33/50

CPC classification number: C08G65/00 ,  A61K31/08 ,  A61K31/16 ,  A61K31/69 ,  C07C235/08 ,  C07H15/08 ,  G01N33/5091

Abstract: There is provided a glucose-PEG conjugate comprising a PEG moiety conjugated to a linear glucose moiety at the C1 position of the glucose moiety. The glucose-PEG conjugate may be used to reduce glucose transport into a cell and may be used to treat a proliferative disorder.

Abstract translation: 提供了包含在葡萄糖部分的C1位上与线性葡萄糖部分缀合的PEG部分的葡萄糖-PEG缀合物。 葡萄糖-PEG轭合物可用于降低葡萄糖转运至细胞中，并可用于治疗增殖性疾病。

公开(公告)号：US20140193849A1

公开(公告)日：2014-07-10

申请号：US14149493

申请日：2014-01-07

Applicant: Agency for Science, Technology and Research

Inventor： Karthikeyan Narayanan ,  Andrew Chwee Aun Wan ,  Jackie Y. Ying ,  Nandanan Erathodiyil

IPC: C08G65/00 ,  G01N33/50

CPC classification number: C08G65/00 ,  A61K31/08 ,  A61K31/16 ,  A61K31/69 ,  C07C235/08 ,  C07H15/08 ,  G01N33/5091

Abstract: There is provided a glucose-PEG conjugate comprising a PEG moiety conjugated to a linear glucose moiety at the C1 position of the glucose moiety. The glucose-PEG conjugate may be used to reduce glucose transport into a cell and may be used to treat a proliferative disorder.

Abstract translation: 提供了包含在葡萄糖部分的C1位上与线性葡萄糖部分缀合的PEG部分的葡萄糖-PEG缀合物。 葡萄糖-PEG轭合物可用于降低葡萄糖转运至细胞中，并可用于治疗增殖性疾病。

公开(公告)号：US20130268060A1

公开(公告)日：2013-10-10

申请号：US13917269

申请日：2013-06-13

Applicant: Agency for Science, Technology and Research

Inventor： Karl M. Schumacher ,  Jackie Y. Ying ,  Annegret Schumacher ,  Karthikeyan Narayanan ,  Gunter Maubach

IPC: C12N5/071 ,  A61F2/06

CPC classification number: C12N5/0686 ,  A61F2/06 ,  C12N2501/11 ,  C12N2501/155 ,  C12N2506/02

Abstract: The present invention relates to methods of differentiating a human embryonic stem (ES) cell into a cell, specifically a renal epithelial cell, expressing AQP-I. The methods disclosed comprise culturing human ES cells in a renal specific medium in the presence of an extracellular matrix molecule. The cells produced according to said method can be used to treat renal related disorders such as renal failure, nephrosis, Bright's disease and glomerulitis.

Abstract translation: 本发明涉及将人胚胎干（ES）细胞分化成表达AQP-1的细胞，特别是肾上皮细胞的方法。 所公开的方法包括在细胞外基质分子的存在下在肾特异性培养基中培养人ES细胞。 根据所述方法产生的细胞可用于治疗肾脏相关疾病如肾衰竭，肾病，光明病和肾小球炎。

公开(公告)号：US10975350B2

公开(公告)日：2021-04-13

申请号：US15780236

申请日：2016-11-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Jackie Y. Ying ,  Nandanan Erathodiyil ,  Karthikeyan Narayanan ,  Andrew C. A. Wan

IPC: C12N5/00 ,  C12N5/0775 ,  B82Y30/00 ,  B82Y5/00

Abstract: A cell culture substrate comprising a substrate having a coating of a plurality of amine functionalized nanoparticles is disclosed. In one embodiment, the amine functionalized nanoparticle is a polymer of an acrylamide monomer, a cross-linker and an amine monomer. There is also provided a method of making the cell culture substrate either by drying the amine functionalized nanoparticles when spread onto the said substrate or by covalent linkages of the substrate with thiol terminated nanoparticles. In addition, there is provided a method of culturing stem cells on the cell culture substrate having a coating of a plurality of the amine functionalized nanoparticles thereon.

公开(公告)号：US10287553B2

公开(公告)日：2019-05-14

申请号：US14395811

申请日：2013-04-22

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Daniele Zink ,  Ming Ni ,  Karthikeyan Narayanan ,  Karthikeyan Kandasamy ,  Andrew C. A. Wan ,  Jackie Y. Ying

IPC: C12N5/074 ,  C12N5/00 ,  C12N5/0735 ,  C12N5/0775

Abstract: There is provided a method for culturing a stem cell in vitro. The method comprises providing a substrate surface coated with a coating comprising a molecule having a catechol moiety or a polymer thereof; and growing a stem cell on said coated substrate surface in a growth medium.

公开(公告)号：US20150087057A1

公开(公告)日：2015-03-26

申请号：US14395811

申请日：2013-04-22

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Daniele Zink ,  Ming Ni ,  Karthikeyan Narayanan ,  Karthikeyan Kandasamy ,  Andrew C.A. Wan ,  Jackie Y. Ying

IPC: C12N5/074 ,  C12N5/0775 ,  C12N5/0735

CPC classification number: C12N5/0696 ,  C12N5/0068 ,  C12N5/0075 ,  C12N5/0606 ,  C12N5/0663 ,  C12N2500/90 ,  C12N2501/815 ,  C12N2531/00 ,  C12N2533/00 ,  C12N2533/20 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/70 ,  C12N2533/78

Abstract: There is provided a method for culturing a stem cell in vitro. The method comprises providing a substrate surface coated with a coating comprising a molecule having a catechol moiety or a polymer thereof; and growing a stem cell on said coated substrate surface in a growth medium.

Abstract translation: 提供了体外培养干细胞的方法。 该方法包括提供涂覆有包含具有儿茶酚部分或其聚合物的分子的涂层的基底表面; 以及在生长培养基中在所述涂覆的基底表面上生长干细胞。