公开(公告)号：US20180170932A1

公开(公告)日：2018-06-21

申请号：US15899675

申请日：2018-02-20

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei Ho ,  Stephanie Eliane BLANCHARD ,  Athisayamani Jeyaraj DURAISWAMY ,  Jenefer ALAM ,  Vikrant Arun ADSOOL

IPC: C07D473/06 ,  C07D473/08 ,  A61K31/522 ,  A61K31/5377

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

公开(公告)号：US20230174533A1

公开(公告)日：2023-06-08

申请号：US18077921

申请日：2022-12-08

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei HO ,  Stephanie Eliane BLANCHARD ,  Athisayamani Jeyaraj DURAISWAMY ,  Jenefer ALAM ,  Vikrant Arun ADSOOL

IPC: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

CPC classification number: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway




wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

公开(公告)号：US20210155623A1

公开(公告)日：2021-05-27

申请号：US17100474

申请日：2020-11-20

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei Ho ,  Stephanie Eliane BLANCHARD ,  Athisayamani Jeyaraj DURAISWAMY ,  Jenefer ALAM ,  Vikrant Arun ADSOOL

IPC: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

公开(公告)号：US20200270255A1

公开(公告)日：2020-08-27

申请号：US16646655

申请日：2018-09-11

Applicant: Agency for Science, Technology and Research

Inventor： Stephanie Eliane BLANCHARD

IPC: C07D487/04

Abstract: The application relates to a 2,6-dioxo-purine derivative, 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-(2-hydroxyphenyl)pyridazin-3-yl)acetamide, and the use of this compound in the modulation of the Wnt pathway, and treating a disease or condition associated with Wnt pathway activity, such as cancer, a fibrotic disease, a degenerative disease or a metabolic disease.