公开(公告)号：US20230391789A1

公开(公告)日：2023-12-07

申请号：US18144641

申请日：2023-05-08

Applicant: Agency for Science, Technology and Research

Inventor： Vikrant Arun ADSOOL

IPC: C07D491/08 ,  C07D215/233 ,  C07D401/12 ,  C07D451/06 ,  C07D451/14

CPC classification number: C07D491/08 ,  C07D215/233 ,  C07D401/12 ,  C07D451/06 ,  C07D451/14

Abstract: The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.

公开(公告)号：US20210309668A1

公开(公告)日：2021-10-07

申请号：US17265175

申请日：2019-07-23

Applicant: Agency for Science, Technology and Research

Inventor： Vikrant Arun ADSOOL

IPC: C07D491/08 ,  C07D215/233 ,  C07D401/12 ,  C07D451/06 ,  C07D451/14

Abstract: The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.

公开(公告)号：US20180170932A1

公开(公告)日：2018-06-21

申请号：US15899675

申请日：2018-02-20

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei Ho ,  Stephanie Eliane BLANCHARD ,  Athisayamani Jeyaraj DURAISWAMY ,  Jenefer ALAM ,  Vikrant Arun ADSOOL

IPC: C07D473/06 ,  C07D473/08 ,  A61K31/522 ,  A61K31/5377

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

公开(公告)号：US20230174533A1

公开(公告)日：2023-06-08

申请号：US18077921

申请日：2022-12-08

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei HO ,  Stephanie Eliane BLANCHARD ,  Athisayamani Jeyaraj DURAISWAMY ,  Jenefer ALAM ,  Vikrant Arun ADSOOL

IPC: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

CPC classification number: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway




wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

公开(公告)号：US20210155623A1

公开(公告)日：2021-05-27

申请号：US17100474

申请日：2020-11-20

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei Ho ,  Stephanie Eliane BLANCHARD ,  Athisayamani Jeyaraj DURAISWAMY ,  Jenefer ALAM ,  Vikrant Arun ADSOOL

IPC: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.