公开(公告)号：US09977014B2

公开(公告)日：2018-05-22

申请号：US14275526

申请日：2014-05-12

Applicant: Agency for Science, Technology and Research

Inventor： Steven Lukman ,  Siu Yee New ,  Xiaodi Su ,  Edwin Chong Wing Cheung

IPC: C12M1/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/553

CPC classification number: G01N33/5308 ,  G01N33/54346 ,  G01N33/553

Abstract: The present invention provides a sensor for sensing nucleic acid-protein interactions, comprising a noble metal nanoparticle (NP), a double stranded nucleic acid molecule capable of binding with a protein in an aqueous solution and a fluorescent conjugated polymer (CP). The present invention also provides a method for sensing nucleic acid-protein interactions with the sensor as defined above.

公开(公告)号：US20140335510A1

公开(公告)日：2014-11-13

申请号：US14275526

申请日：2014-05-12

Applicant: Agency for Science, Technology and Research

Inventor： Steven Lukman ,  Siu Yee New ,  Xiaodi Su ,  Edwin Chong Wing Cheung

IPC: C12Q1/68

CPC classification number: G01N33/5308 ,  G01N33/54346 ,  G01N33/553

Abstract: The present invention provides a sensor for sensing nucleic acid-protein interactions, comprising a noble metal nanoparticle (NP), a double stranded nucleic acid molecule capable of binding with a protein in an aqueous solution and a fluorescent conjugated polymer (CP). The present invention also provides a method for sensing nucleic acid-protein interactions with the sensor as defined above.

Abstract translation: 本发明提供一种用于感测核酸 - 蛋白质相互作用的传感器，其包含贵金属纳米颗粒（NP），能够与水溶液中的蛋白质结合的双链核酸分子和荧光共轭聚合物（CP）。 本发明还提供了如上定义的用于感测与传感器的核酸 - 蛋白质相互作用的方法。