公开(公告)号：US20230339983A1

公开(公告)日：2023-10-26

申请号：US18182332

申请日：2023-03-11

Applicant: Agency for Science, Technology and Research

Inventor： Sandhya Sriram ,  Shigeki Sugii ,  Young Tae Chang ,  Nam-Young Kang

IPC: C07F5/02 ,  C12N5/0735 ,  C12N5/074 ,  G01N33/58

CPC classification number: C07F5/022 ,  C12N5/0606 ,  C12N5/0696 ,  G01N33/582

Abstract: Determining, in a sample, the presence and/or amount of pluripotent stem cells. A sample suspected of containing one or more pluripotent stem cells is provided. The sample with a fluorescent compound is contacted under conditions that allow binding of the fluorescent compound to the pluripotent stem cells, where the fluorescent compound is a fluorescent compound of formula (I) or a pharmaceutically acceptable salt thereof. The presence and/or amount of the pluripotent stem cells is determined by measuring the fluorescence of the cells following the contacting.

公开(公告)号：US11634437B2

公开(公告)日：2023-04-25

申请号：US16620792

申请日：2018-07-04

Applicant: Agency for Science, Technology and Research

Inventor： Sandhya Sriram ,  Shigeki Sugii ,  Young Tae Chang ,  Nam-Young Kang

IPC: G01N33/58 ,  C12N5/0735 ,  C07F5/02 ,  C12N5/074

Abstract: The present invention provides fluorescent compounds of formula (I) as disclosed herein or pharmaceutically acceptable salts thereof. Further provided are uses of said fluorescent compounds in methods of determining, in a sample, the presence and/or amount of pluripotent stem cells or cells undergoing reprogramming to become induced pluripotent stem cells.