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公开(公告)号：US20150355168A1
公开(公告)日：2015-12-10
申请号：US14759015
申请日：2014-01-14
Inventor： Young-Tae Chang , Duanting Zhai , Sung-Chan Lee , Seong-Wook Yun , Yun-Mi Jeong , Nam-Young Kang , Sung-Jin Park
CPC classification number: G01N33/5091 , C07F5/022 , C09B23/0075 , C09B23/04 , G01N33/5005 , G01N33/582
Abstract: The present invention is directed to a novel family of fluorophores based on the BODIPY scaffold, and methods for their synthesis. The BODIPY-based fluorophores disclosed herein are used for the selective visualization of cells that exist in the M-phase of the cell cycle. The present invention further relates to methods for the image-based monitoring of mitotic progression in live cells.
Abstract translation: 本发明涉及一种基于BODIPY支架的新型荧光团家族及其合成方法。 本文公开的基于BODIPY的荧光团用于选择性地观察存在于细胞周期M期的细胞。 本发明还涉及用于活细胞中有丝分裂进展的基于图像的监测方法。
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2.发明公开公开(公告)号：US20230339983A1
公开(公告)日：2023-10-26
申请号：US18182332
申请日：2023-03-11
Applicant: Agency for Science, Technology and Research
Inventor： Sandhya Sriram , Shigeki Sugii , Young Tae Chang , Nam-Young Kang
IPC: C07F5/02 , C12N5/0735 , C12N5/074 , G01N33/58
CPC classification number: C07F5/022 , C12N5/0606 , C12N5/0696 , G01N33/582
Abstract: Determining, in a sample, the presence and/or amount of pluripotent stem cells. A sample suspected of containing one or more pluripotent stem cells is provided. The sample with a fluorescent compound is contacted under conditions that allow binding of the fluorescent compound to the pluripotent stem cells, where the fluorescent compound is a fluorescent compound of formula (I) or a pharmaceutically acceptable salt thereof. The presence and/or amount of the pluripotent stem cells is determined by measuring the fluorescence of the cells following the contacting.
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Patent Agency Ranking
3.发明授权公开(公告)号：US09423396B2
公开(公告)日：2016-08-23
申请号：US14367596
申请日：2012-12-20
Inventor： Young-Tae Chang , Sung Chan Lee , Nam-Young Kang , Seong Wook Yun , Cheryl Kit Mun Leong , Hyung Ho Ha
IPC: G01N33/53 , C07F5/02 , G01N33/569 , G01N33/58 , A61K49/00
CPC classification number: G01N33/5306 , A61K49/0021 , A61K49/006 , C07F5/02 , C07F5/022 , C09B23/0075 , C09B23/145 , G01N33/56966 , G01N33/582 , G01N2458/00
Abstract: The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of beta cells, pancreatic islets and microglia cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can also differentiate healthy pancreatic islet cells from diabetic pancreatic islet cells.
Abstract translation: 本发明涉及由结构式（I）表示的对神经干细胞特异性的荧光化合物：（I）或其药学上可接受的盐。 结构式（I）的变量在本文中定义。 还描述了检测β细胞，胰岛和小神经胶质细胞的方法，其包括使用结构式（I）的化合物或其药学上可接受的盐。 结构式（I）的化合物还可以将健康的胰岛细胞与糖尿病胰岛细胞分化。
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公开(公告)号：US20140359794A1
公开(公告)日：2014-12-04
申请号：US14367596
申请日：2012-12-20
Inventor： Young-Tae Chang , Sung Chan Lee , Nam-Young Kang , Seong Wook Yun , Cheryl Kit Mun Leong , Hyung Ho Ha
CPC classification number: G01N33/5306 , A61K49/0021 , A61K49/006 , C07F5/02 , C07F5/022 , C09B23/0075 , C09B23/145 , G01N33/56966 , G01N33/582 , G01N2458/00
Abstract: The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of beta cells, pancreatic islets and microglia cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can also differentiate healthy pancreatic islet cells from diabetic pancreatic islet cells.
Abstract translation: 本发明涉及由结构式（I）表示的对神经干细胞特异性的荧光化合物：（I）或其药学上可接受的盐。 结构式（I）的变量在本文中定义。 还描述了检测β细胞，胰岛和小神经胶质细胞的方法，其包括使用结构式（I）的化合物或其药学上可接受的盐。 结构式（I）的化合物还可以将健康的胰岛细胞与糖尿病胰岛细胞分化。
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公开(公告)号：US11634437B2
公开(公告)日：2023-04-25
申请号：US16620792
申请日：2018-07-04
Applicant: Agency for Science, Technology and Research
Inventor： Sandhya Sriram , Shigeki Sugii , Young Tae Chang , Nam-Young Kang
IPC: G01N33/58 , C12N5/0735 , C07F5/02 , C12N5/074
Abstract: The present invention provides fluorescent compounds of formula (I) as disclosed herein or pharmaceutically acceptable salts thereof. Further provided are uses of said fluorescent compounds in methods of determining, in a sample, the presence and/or amount of pluripotent stem cells or cells undergoing reprogramming to become induced pluripotent stem cells.
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公开(公告)号：US09423395B2
公开(公告)日：2016-08-23
申请号：US14759015
申请日：2014-01-14
Inventor： Young-Tae Chang , Duanting Zhai , Sung-Chan Lee , Seong-Wook Yun , Yun-Mi Jeong , Nam-Young Kang , Sung-Jin Park
CPC classification number: G01N33/5091 , C07F5/022 , C09B23/0075 , C09B23/04 , G01N33/5005 , G01N33/582
Abstract: The present invention is directed to a novel family of fluorophores based on the BODIPY scaffold, and methods for their synthesis. The BODIPY-based fluorophores disclosed herein are used for the selective visualization of cells that exist in the M-phase of the cell cycle. The present invention further relates to methods for the image-based monitoring of mitotic progression in live cells.
Abstract translation: 本发明涉及一种基于BODIPY支架的新型荧光团家族及其合成方法。 本文公开的基于BODIPY的荧光团用于选择性地观察存在于细胞周期M期的细胞。 本发明还涉及用于活细胞中有丝分裂进展的基于图像的监测方法。
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7.发明申请公开(公告)号：US20130101517A1
公开(公告)日：2013-04-25
申请号：US13625832
申请日：2012-09-24
Inventor： Young-Tae Chang , Animesh Samanta , Marc Vendrell Escobar , Nam-Young Kang , Kaustabh Kumar Maiti , Kiat Seng Soh , Dinish Unnimadhava Kurup Soudamini Amma , Malini Olivo , Sung-Jin Park
IPC: G01N21/65
CPC classification number: G01N21/658 , A61K49/0032 , A61K49/0058 , C09B23/0016 , C09B23/0041 , C09B23/0066 , C09B23/086 , G01N33/582
Abstract: A compound of structural formula (I): The values and alternative values are as defined herein. The invention also includes biosensors comprising nanoparticles functionalized with a compound of structural formula (I). Also described is a method for labeling a biomolecule using a compound of structural formula (I) and a method of detecting a target biomolecule using a compound of structural formula (I) or a biosensor of the invention.
Abstract translation: 结构式（I）的化合物：值和替代值如本文所定义。 本发明还包括包含用结构式（I）化合物官能化的纳米颗粒的生物传感器。 还描述了使用结构式（I）的化合物和使用本发明的结构式（I）的化合物或本发明的生物传感器检测靶生物分子的方法来标记生物分子的方法。
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