公开(公告)号：US20230288429A1

公开(公告)日：2023-09-14

申请号：US18119195

申请日：2023-03-08

Applicant: Agilent Technologies, Inc.

Inventor： Xiao Xu ,  Yama A. Abassi ,  Xiaobo Wang ,  Jiangbo Gan

IPC: G01N33/68 ,  C12M1/12 ,  C12M1/34 ,  G01N33/50 ,  G01N33/483

CPC classification number: G01N33/6854 ,  C12M25/08 ,  C12M41/36 ,  G01N33/5005 ,  G01N33/4836 ,  G01N2500/10

Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.

公开(公告)号：US20230145666A1

公开(公告)日：2023-05-11

申请号：US18095402

申请日：2023-01-10

Applicant: Agilent Technologies, Inc.

Inventor： Xiao Xu ,  Yama A. Abassi ,  Xiaobo Wang ,  Jiangbo Gan

IPC: G01N33/68 ,  C12M1/12 ,  C12M1/34 ,  G01N33/50 ,  G01N33/483

CPC classification number: G01N33/6854 ,  C12M25/08 ,  C12M41/36 ,  G01N33/4836 ,  G01N33/5005 ,  G01N2500/10

Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.

公开(公告)号：US11604197B2

公开(公告)日：2023-03-14

申请号：US16833180

申请日：2020-03-27

Applicant: Agilent Technologies, Inc.

Inventor： Xiao Xu ,  Yama A. Abassi ,  Xiaobo Wang ,  Jiangbo Gan

IPC: G01N33/68 ,  C12M1/12 ,  C12M1/34 ,  G01N33/50 ,  G01N33/483

Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.