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公开(公告)号：US09281173B2
公开(公告)日：2016-03-08
申请号：US13906023
申请日：2013-05-30
CPC分类号： H01J49/062 , G01N27/622 , H01J49/26
摘要： An ion processing device includes electrically conductive vacuum manifold segments serially positioned and enclosing a volume along an axis. The segments are electrically isolated from each other and independently addressable by a voltage source. An ion optics device is positioned in the volume. A voltage differential between each manifold segment and the ion optics device is maintained below a maximum value by applying different voltages to respective manifold segments. The voltage differential may be controlled to avoid voltage breakdown in a low-pressure, high-voltage gas environment. The ion optics device may in some cases be an ion mobility drift cell.
摘要翻译： 离子处理装置包括串联定位并围绕轴线包围体积的导电真空歧管段。 这些段彼此电隔离并且可被电压源独立地寻址。 离子光学器件位于体积中。 每个歧管段和离子光学器件之间的电压差通过向相应的歧管段施加不同的电压而保持在最大值之下。 可以控制电压差以避免在低压，高压气体环境中的电压击穿。 在一些情况下，离子光学器件可能是离子迁移率漂移单元。
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公开(公告)号：US09916968B1
公开(公告)日：2018-03-13
申请号：US15365935
申请日：2016-11-30
CPC分类号： H01J49/005 , H01J49/10
摘要： An electrode assembly is provided in a high sub-atmospheric pressure region of an ion source, between an ionization chamber and a vacuum region of a spectrometer, such as a mass spectrometer, an ion mobility spectrometer, or an ion mobility-mass spectrometer. The electrode assembly is spaced at a distance from an outlet of an ion transfer device. A voltage source imparts a potential difference between the ion transfer device and the electrode assembly to accelerate ions emitted from the outlet to a collision energy. The collision energy is effective to cause collisional heating of ions in the high sub-atmospheric pressure region without voltage breakdown. The collision energy may be set to cause unfolding of folded biomolecular ions and/or dissociation of ions.
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3.发明授权Fast method for measuring collision cross section of ions utilizing ion mobility spectrometry 有权使用离子迁移谱法测量离子碰撞截面的快速方法公开(公告)号：US09482642B2
公开(公告)日：2016-11-01
申请号：US14170068
申请日：2014-01-31
CPC分类号： G01N27/622 , H01J49/0009 , H01J49/0031
摘要： The collision cross section (CCS) of a sample ion may be calculated by measuring a total drift time taken by the sample ion to travel through an ion mobility spectrometry drift cell to an ion detector. The CCS may be calculated based on the total drift time measured, and on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility dominated region between the drift cell and the detector. The proportionality coefficient may be determined from measuring the total drift times of reference ions. Calculation of the CCS of the sample ion may also be based on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility-independent region where the velocity of the ion depends on the electrostatic field strength, mass and the charge state of the ion.
摘要翻译： 样品离子的碰撞横截面（CCS）可以通过测量样品离子通过离子迁移光谱漂移池移动到离子检测器所需的总漂移时间来计算。 CCS可以基于所测量的总漂移时间以及定义由样品离子穿过漂移池和检测器之间的迁移率控制区域所花费的时间的比例系数来计算。 可以通过测量参考离子的总漂移时间来确定比例系数。 样品离子的CCS的计算也可以基于比例系数，其定义了样品离子行进通过不依赖于迁移率的区域所花费的时间，其中离子的速度取决于静电场强度，质量和电荷 离子的状态。
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公开(公告)号：US10267765B2
公开(公告)日：2019-04-23
申请号：US15099178
申请日：2016-04-14
摘要： In an ion mobility-mass spectrometry (IM-MS) system, an ion mass-isolated data set is acquired by operating a mass filter to apply a mass isolation window having an m/z width such that the mass isolation window moves through a sequence of window positions, each window position being defined by an IM drift time value and an m/z ratio value. The m/z width of the mass isolation window and the sequence of window positions are determined such that the mass isolation window captures ions in a region of interest of a larger all-ions data set. The isolation window may be a wideband isolation window. In comparison to the all-ions data set, the mass-isolated data set may yield reduced ion signal interference and increased selectivity for analytes of interest.
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5.发明申请AUTOMATIC DETERMINATION OF DEMULTIPLEXING MATRIX FOR ION MOBILITY SPECTROMETRY AND MASS SPECTROMETRY 审中-公开用于离子电离分光光谱和质谱分析的自组织矩阵自动测定公开(公告)号：US20160172171A1
公开(公告)日：2016-06-16
申请号：US14873363
申请日：2015-10-02
发明人： Jun Wang , Ruwan T. Kurulugama
CPC分类号： H01J49/0036 , H01J49/004 , H01J49/40
摘要： Multiplexed ion mobility spectrometry (IMS), mass spectrometry (MS) such as time-of-flight mass spectrometry (TOFMS), or hybrid IM-MS is carried out on a sample, and the resulting measurement data are deconvoluted. A pulse sequence controlling ion pulsing is utilized in conjunction with the multiplexing. The pulse sequence may be modified based on the raw measurement data acquired. A demultiplexing matrix based on the modified pulse sequence is utilized to improve deconvolution.
摘要翻译： 对样品进行多重离子淌度光谱法（IMS），质谱（MS）如飞行时间质谱（TOFMS）或混合IM-MS，并将所得测量数据解卷积。 控制离子脉冲的脉冲序列与多路复用结合使用。 可以基于获得的原始测量数据来修改脉冲序列。 基于修正的脉冲序列的解复用矩阵被用于改进去卷积。
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公开(公告)号：US20140353483A1
公开(公告)日：2014-12-04
申请号：US13906023
申请日：2013-05-30
CPC分类号： H01J49/062 , G01N27/622 , H01J49/26
摘要： An ion processing device includes electrically conductive vacuum manifold segments serially positioned and enclosing a volume along an axis. The segments are electrically isolated from each other and independently addressable by a voltage source. An ion optics device is positioned in the volume. A voltage differential between each manifold segment and the ion optics device is maintained below a maximum value by applying different voltages to respective manifold segments. The voltage differential may be controlled to avoid voltage breakdown in a low-pressure, high-voltage gas environment. The ion optics device may in some cases be an ion mobility drift cell.
摘要翻译： 离子处理装置包括串联定位并围绕轴线包围体积的导电真空歧管段。 这些段彼此电隔离并且可被电压源独立地寻址。 离子光学器件位于体积中。 每个歧管段和离子光学器件之间的电压差通过向相应的歧管段施加不同的电压而保持在最大值之下。 可以控制电压差以避免在低压，高压气体环境中的电压击穿。 在一些情况下，离子光学器件可能是离子迁移率漂移单元。
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7.发明授权公开(公告)号：US10037873B2
公开(公告)日：2018-07-31
申请号：US14873363
申请日：2015-10-02
发明人： Jun Wang , Ruwan T. Kurulugama
CPC分类号： H01J49/0036 , H01J49/004 , H01J49/40
摘要： Multiplexed ion mobility spectrometry (IMS), mass spectrometry (MS) such as time-of-flight mass spectrometry (TOFMS), or hybrid IM-MS is carried out on a sample, and the resulting measurement data are deconvoluted. A pulse sequence controlling ion pulsing is utilized in conjunction with the multiplexing. The pulse sequence may be modified based on the raw measurement data acquired. A demultiplexing matrix based on the modified pulse sequence is utilized to improve deconvolution.
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公开(公告)号：US20180053640A1
公开(公告)日：2018-02-22
申请号：US15365935
申请日：2016-11-30
CPC分类号： H01J49/005 , H01J49/10
摘要： An electrode assembly is provided in a high sub-atmospheric pressure region of an ion source, between an ionization chamber and a vacuum region of a spectrometer, such as a mass spectrometer, an ion mobility spectrometer, or an ion mobility-mass spectrometer. The electrode assembly is spaced at a distance from an outlet of an ion transfer device. A voltage source imparts a potential difference between the ion transfer device and the electrode assembly to accelerate ions emitted from the outlet to a collision energy. The collision energy is effective to cause collisional heating of ions in the high sub-atmospheric pressure region without voltage breakdown. The collision energy may be set to cause unfolding of folded biomolecular ions and/or dissociation of ions.
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9.发明授权Ion mobility spectrometry-mass spectrometry (IMS-MS) with improved ion transmission and IMS resolution 有权离子迁移光谱 - 质谱（IMS-MS）具有改进的离子传输和IMS分辨率公开(公告)号：US09455132B2
公开(公告)日：2016-09-27
申请号：US13906095
申请日：2013-05-30
CPC分类号： H01J49/062 , G01N27/622
摘要： An interface for an ion mobility spectrometry-mass spectrometry (IMS-MS) system includes a first ion guide for receiving ions from an IMS drift cell, and a second ion guide for receiving ions from the first ion guide, and positioned in a chamber separate from the first ion guide. Electrodes of the second ion guide subject the ions to an axial DC electric field while the second ion guide is held at a lower pressure than the first ion guide. In some embodiments, the first ion guide may be an ion funnel and the second ion guide may be a linear multipole device.
摘要翻译： 用于离子迁移光谱 - 质谱（IMS-MS）系统的界面包括用于接收来自IMS漂移单元的离子的第一离子引导件和用于接收来自第一离子导向器的离子的第二离子引导件， 从第一离子导向器。 第二离子导向器的电极将离子导向轴向DC电场，而第二离子导向器保持在比第一离子导向器更低的压力下。 在一些实施例中，第一离子导向器可以是离子漏斗，并且第二离子导向器可以是线性多极装置。
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10.发明申请FAST METHOD FOR MEASURING COLLISION CROSS SECTION OF IONS UTILIZING ION MOBILITY SPECTROMETRY 有权快速测定离子交换色谱离子离子交换色谱的方法公开(公告)号：US20150219598A1
公开(公告)日：2015-08-06
申请号：US14170068
申请日：2014-01-31
CPC分类号： G01N27/622 , H01J49/0009 , H01J49/0031
摘要： The collision cross section (CCS) of a sample ion may be calculated by measuring a total drift time taken by the sample ion to travel through an ion mobility spectrometry drift cell to an ion detector. The CCS may be calculated based on the total drift time measured, and on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility dominated region between the drift cell and the detector. The proportionality coefficient may be determined from measuring the total drift times of reference ions. Calculation of the CCS of the sample ion may also be based on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility-independent region where the velocity of the ion depends on the electrostatic field strength, mass and the charge state of the ion.
摘要翻译： 样品离子的碰撞横截面（CCS）可以通过测量样品离子通过离子迁移光谱漂移池移动到离子检测器所需的总漂移时间来计算。 CCS可以基于所测量的总漂移时间以及定义由样品离子穿过漂移池和检测器之间的迁移率控制区域所花费的时间的比例系数来计算。 可以通过测量参考离子的总漂移时间来确定比例系数。 样品离子的CCS的计算也可以基于比例系数，其定义了样品离子行进通过不依赖于迁移率的区域所花费的时间，其中离子的速度取决于静电场强度，质量和电荷 离子的状态。
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