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公开(公告)号:US20240047186A1
公开(公告)日:2024-02-08
申请号:US18488633
申请日:2023-10-17
Applicant: Quest Diagnostics Investments LLC
Inventor: Scott Goldman
CPC classification number: H01J49/0036 , G01N33/92 , H01J49/0027 , H01J49/426 , H01J49/10 , Y10T436/201666 , Y10T436/200833 , Y10T436/20 , G01N2560/00
Abstract: The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry.
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公开(公告)号:US11848187B2
公开(公告)日:2023-12-19
申请号:US17718526
申请日:2022-04-12
Applicant: Micromass UK Limited
Inventor: Frank Buckley , Roger Smith
CPC classification number: H01J49/401 , H01J49/0086 , H01J49/022 , H01J49/10 , H01J49/403 , H02M1/14 , H02M1/0016
Abstract: A drive unit for driving an acceleration electrode of a mass spectrometer is disclosed. The drive unit includes a power converter comprising a switching element and pulsing circuitry that can form output pulses suitable for driving an acceleration electrode of a mass spectrometer. The drive unit also includes a controller that is configured to synchronise operation of the switching element with the pulsing circuitry.
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公开(公告)号:US11835505B2
公开(公告)日:2023-12-05
申请号:US17893950
申请日:2022-08-23
Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
Inventor: Nigel Clarke
CPC classification number: G01N33/15 , G01N30/7233 , G01N33/49 , G01N33/94 , H01J49/004 , H01J49/0031 , H01J49/0045 , H01J49/10 , G01N33/48 , H01J49/00 , Y10T436/17 , Y10T436/24 , Y10T436/25125 , Y10T436/25375
Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, N-Desmethyl Tamoxifen, and other tamoxifen metabolites.
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公开(公告)号:US20230343572A1
公开(公告)日:2023-10-26
申请号:US18037097
申请日:2021-12-28
Applicant: Hitachi High-Tech Corporation
Inventor: Zihao ONG , Takuma NISHIMOTO , Isao FURUYA , Hiroshi TOUDA
IPC: H01J49/10
CPC classification number: H01J49/10
Abstract: A high-voltage module HVMD includes: an error amplifier configured to output a control signal based on a reference signal Vin and a feedback signal; a high voltage output circuit configured to output a high voltage Vout for supply based on the control signal; and a feedback circuit configured to output the feedback signal based on the high voltage Vout for supply. Here, the feedback circuit includes: a first partial circuit configured to receive an input of the high voltage Vout for supply and to output an intermediate signal, the first partial circuit including a resistance element; and a second partial circuit configured to receive an input of the intermediate signal and to output the feedback signal. The high-voltage module HVMD further includes a substrate SUB including: a high voltage substrate region where the high voltage output circuit and a part of the first partial circuit are mounted.
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公开(公告)号:US20230170897A1
公开(公告)日:2023-06-01
申请号:US17951700
申请日:2022-09-23
Applicant: Shimadzu Corporation
Inventor: Haruki OSA
IPC: H03K17/567 , H01F19/04 , H02M7/217 , H03K17/06
CPC classification number: H03K17/567 , H01F19/04 , H02M7/217 , H03K17/063 , H01J49/10
Abstract: A high-voltage power supply device includes a voltage generation unit for outputting a DC high-voltage, a switching unit using a semiconductor switching element, the switching unit being configured to output an output voltage by the voltage generation unit to a voltage output terminal in a conduction state, a driver for driving a control terminal of the semiconductor switching element, and a controller for controlling the switching unit via the driver. The driver includes a high-frequency transformer provided with primary and secondary windings, a distribution of a stray capacitance per number of unit turns of the primary winding between the primary and secondary windings in an extension direction of the primary winding being symmetrical to a midpoint of the primary winding, a rectifier for rectifying an AC current induced in the secondary winding, and a balanced output type high-frequency excitation unit for exciting the primary winding differentially.
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公开(公告)号:US20190237314A1
公开(公告)日:2019-08-01
申请号:US15753621
申请日:2016-08-19
Applicant: PHARMACADENCE ANALYTICAL SERVICES, LLC
Inventor: RICHARD C. KING, III , WILLIAM J. METZLER, IV
CPC classification number: H01J49/0009 , G01N27/622 , G01R19/0061 , H01J49/027 , H01J49/10 , H01J49/165 , H01J49/168 , H01J49/30
Abstract: The present invention comprises novel methods of continuously monitoring the performance of an atmospheric pressure ionization (API) system. The methods of the invention allow for improved quality monitoring of the processes that leads to the formation of ions at atmospheric pressure. The methods of the invention further allow for continuously monitoring for the quality of the ion formation process in API without the addition of extraneous material (such as labelled compounds or control known compounds) to the system being monitored.
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公开(公告)号:US20190019660A1
公开(公告)日:2019-01-17
申请号:US16133149
申请日:2018-09-17
Applicant: Quest Diagnostics Investments Incorporated
Inventor: J. Fred BANKS , Peter P. CHOU , Noriya M. MATT
CPC classification number: H01J49/04 , G01N30/7233 , G01N33/6848 , G01N33/78 , G01N2560/00 , H01J49/00 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0081 , H01J49/0431 , H01J49/10
Abstract: Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.
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公开(公告)号:US20180330936A1
公开(公告)日:2018-11-15
申请号:US15776585
申请日:2016-11-16
Applicant: MICROMASS UK LIMITED , LECO CORPORATION
Inventor: John Brian Hoyes , Anatoly Verenchikov , Mikhail Yavor , Keith Richardson , Jason Wildgoose
CPC classification number: H01J49/405 , H01J49/0004 , H01J49/062 , H01J49/067 , H01J49/10 , H01J49/406
Abstract: A time-of-flight mass spectrometer is disclosed comprising ion optics that map an array of ions at an ion source array (71) to a corresponding array of positions on a position sensitive ion detector (79). The ion optics include at least one gridless ion mirror (76) for reflecting ions, which may compensate for various aberrations and allows the spectrometer to have relatively high mass and spatial resolutions.
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公开(公告)号:US20180330932A1
公开(公告)日:2018-11-15
申请号:US16033447
申请日:2018-07-12
Applicant: Micromass UK Limited
Inventor: Zoltan TAKATS , Emrys JONES , James Ian LANGRIDGE , Michael Raymond MORRIS , Tamas KARANCSI , Steven Derek PRINGLE , Julia BALOG , Daniel SIMON , Lajos GODORHAZY , Daniel SZALAY , Keith RICHARDSON , Phillip Robert BENNETT , David Alan MACINTYRE , Pamela PRUSKI
IPC: H01J49/04 , H01J49/26 , H01J49/24 , H01J49/16 , H01J49/14 , H01J49/10 , H01J49/06 , H01J49/02 , H01J49/00 , G01N33/92 , G01N33/68 , G01N33/487 , G01N30/72 , G01N27/62 , G01N9/00 , G01N3/00 , G01N1/22 , C12Q1/24 , C12Q1/18 , C12Q1/04 , C12Q1/02 , A61F13/38 , A61B18/20 , A61B18/18 , A61B18/14 , A61B18/04 , A61B18/00 , A61B17/32 , A61B17/00 , A61B10/02 , A61B10/00 , A61B8/13 , A61B6/03 , A61B5/055 , A61B5/05 , A61B5/01 , A61B5/00 , A61B1/04 , A61B90/13 , G06F19/18 , A61B5/145 , A61B1/31 , A61B1/00 , G16H50/20 , G16H15/00 , G16H10/40
CPC classification number: G01N1/2202 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/18 , G06F19/324 , G06F19/3481 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/049 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.
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公开(公告)号:US20180286653A1
公开(公告)日:2018-10-04
申请号:US15471507
申请日:2017-03-28
Inventor: Frank Sinclair , Joseph C. Olson , Costel Biloiu , Alexandre Likhanskii , Peter F. Kurunczi
CPC classification number: H01J49/061 , H01J37/05 , H01J37/3171 , H01J49/10 , H01J49/22
Abstract: An electrodynamic mass analysis system which has the capability of filtering unwanted species from an extracted ion beam without the use of a mass analyzer magnet is disclosed. The electrodynamic mass analysis system includes an ion source and an electrode disposed outside the ion source. The ion source and the electrode are biased relative to one another so as to emit pulses of ions. Each of these pulses enters a tube where each ion travels at a speed related to its mass. Thus, ions of the same mass travel in clusters through the tube. Ions reach the distal end of the tube separated temporally and spatially from one another based on their mass. The ions then enter a deflector, which is energized so as to allow the cluster of ions having the desired mass to pass through a resolving aperture disposed at the exit of the deflector.
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