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    Ostomy bags and vessels for biological materials
    3.
    发明授权
    Ostomy bags and vessels for biological materials 失效
    造口袋和生物材料容器

    公开(公告)号：US06179818B2

    公开(公告)日：2001-01-30

    申请号：US08338917

    申请日：1994-11-14

    申请人： Agis Kydonieus ,  Cuilian Lin ,  Kishore Shah ,  Leslie Klem

    发明人： Agis Kydonieus ,  Cuilian Lin ,  Kishore Shah ,  Leslie Klem

    IPC分类号： A61F1315

    CPC分类号： A61F5/445 ,  A61L28/0007 ,  A61L28/0034

    摘要： The invention provides a vessel for biological materials comprising a multilayer polymeric barrier material that has very low permeability to small molecules, such as water and oxygen, high flexibility and softness, and is resistant to tearing. The invention is particularly useful for forming vessels that receive biological fluids, such as ostomy bags and bags for storing blood, blood products, and IV solutions. The vessel comprises a flexible, multilayer, polymeric barrier material comprising (1) a first sandwich polymer layer, (2) at least one sandwiched, oriented liquid crystal polymer layer, and (3) a second sandwich polymer layer, the first and second sandwich layers disposed to sandwich the liquid crystal layer therebetween.

    摘要翻译： 本发明提供了一种用于生物材料的容器，其包括对小分子（例如水和氧）具有非常低的渗透性，高柔性和柔软性并且耐撕裂性的多层聚合物阻隔材料。 本发明特别可用于形成容纳生物流体的血管，例如造口袋和用于储存血液的血袋，血液制品和IV溶液。 该容器包括柔性多层聚合物阻挡材料，其包含（1）第一夹层聚合物层，（2）至少一个夹层取向液晶聚合物层和（3）第二夹层聚合物层，第一和第二夹层 设置在其间夹着液晶层的层。

    Polyurethane pressure-sensitive adhesives
    4.
    发明授权
    Polyurethane pressure-sensitive adhesives 失效
    聚氨酯压敏粘合剂

    公开(公告)号：US5910536A

    公开(公告)日：1999-06-08

    申请号：US772217

    申请日：1996-12-19

    申请人： Agis Kydonieus ,  Kishore Shah ,  Aruna Nathan

    发明人： Agis Kydonieus ,  Kishore Shah ,  Aruna Nathan

    IPC分类号： C08F290/06 ,  C08F2/50 ,  C08G18/10 ,  C08G18/67 ,  C08G18/81 ,  C09J175/14 ,  C09J175/16 ,  C08J3/00 ,  C08J3/28 ,  C08K3/20 ,  C08L75/00

    CPC分类号： C09J175/16 ,  C08G18/10 ,  C08G18/6715 ,  C08G18/672 ,  C08G18/8116 ,  C08G2170/40

    摘要： Methods for producing poly�urethane-(meth)acrylate!-based adhesives in which an isocyanate-terminated prepolymer is reacted to convert the isocyanate terminal groups into groups capable of cross-linking with each other, excess isocyanate groups are quenched with an isocyanate group quenching compound and the resulting prepolymer is then irradiated or heated to form the polyurethane-based adhesives, and adhesives produced thereby. Alternatively, a hydroxyl-terminated prepolymer is reacted with a reagent having isocyanate and methacrylate groups to form a prepolymer which is then irradiated or heated.

    摘要翻译： 使异氰酸酯封端的预聚物反应以将异氰酸酯端基转化为能够交联的基团的聚[氨基甲酸酯 - （甲基）丙烯酸酯]基粘合剂的制备方法，过量的异氰酸酯基团用异氰酸酯基团 然后将淬火化合物和所得预聚物照射或加热以形成聚氨酯基粘合剂，以及由此制备的粘合剂。 或者，羟基封端的预聚物与具有异氰酸酯和甲基丙烯酸酯基团的试剂反应以形成预聚物，然后将其预辐射或加热。

    Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
    5.
    发明授权
    Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer 失效
    用于控制释放和递送至包含含丙烯酸烷基酯共聚物的速率控制构件的药理学活性剂的哺乳动物组织的装置

    公开(公告)号：US5310559A

    公开(公告)日：1994-05-10

    申请号：US964478

    申请日：1992-10-21

    申请人： Kishore Shah ,  Agis Kydonieus

    发明人： Kishore Shah ,  Agis Kydonieus

    IPC分类号： A61K9/70 ,  A61K31/21 ,  A61M31/00 ,  A61F13/00

    CPC分类号： A61K9/703 ,  A61K31/21 ,  A61K9/7053 ,  A61K9/7084 ,  A61M31/002

    摘要： Described is a device for the controlled release and delivery to mammalian tissue of a pharmacologically active agent comprising:(i) an impermeable backing member;(ii) a control membrane lamina consisting essentially of a first polymeric composition of matter which consists essentially of at least one C.sub.2 -C.sub.4 lower olefin-C.sub.1 -C.sub.8 alkyl acrylate and/or methacrylate copolymer having 2-90% by weight of alkyl acrylate and/or methacrylate monomeric units, taken alone, or taken further together with in intimate admixture, a second polymeric composition consisting essentially of a C.sub.2 -C.sub.4 polyalkylene corresponding to the C.sub.2 -C.sub.4 lower alkylene of said copolymer, said second polymeric composition being compatible with said first polymeric composition of matter; and(iii) a pharmacologically active agent reservoir maintained there between comprising said pharmacologically active agent and a carrier therefor and, optionally, one or more excipients and/or enhancers; and(iv) means for maintaining said device in pharmacologically active agent transmitting relationship to the mammalian tissue to be treated.

    摘要翻译： 描述了用于控制释放和递送到哺乳动物组织的药理活性剂的装置，包括：（i）不可渗透的背衬构件; （ii）主要由物质的第一聚合物组合物组成的对照膜层，其主要由至少一种具有2-90重量％的丙烯酸烷基酯的丙烯酸C 2 -C 4低级烯烃-C 1 -C 8烷基酯和/或甲基丙烯酸酯共聚物组成， 或独立地取代或以紧密混合物进一步取代，第二聚合物组合物基本上由对应于所述共聚物的C 2 -C 4低级亚烷基的C 2 -C 4聚亚烷基组成，所述第二聚合物组合物与所述 物质的第一聚合物组成; 和（iii）保持在其间的药理学活性剂储存器，其包含所述药理活性剂及其载体，以及任选的一种或多种赋形剂和/或增强剂; 和（iv）用于将所述装置维持在与要治疗的哺乳动物组织发生关系的药理活性剂中的装置。