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公开(公告)号:US20220218716A1
公开(公告)日:2022-07-14
申请号:US17595746
申请日:2020-05-22
发明人: Thomas M. ROSSI , Beth DROLET , Agis KYDONIEUS
IPC分类号: A61K31/5377 , A61K31/222 , A61K9/00 , A61K47/10 , A61K47/38
摘要: Transdermal delivery of beta blockers to treat Infantile Hemangiomas.
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公开(公告)号:US09198919B2
公开(公告)日:2015-12-01
申请号:US13123026
申请日:2009-10-07
申请人: Thomas M. Rossi , Marie Foegh , Agis Kydonieus
发明人: Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号: A61K31/565 , A61K31/57 , A61K9/70 , A61K31/56 , A61K31/535 , A61K31/567
CPC分类号: A61K31/567 , A61K9/0014 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/535 , A61K31/56 , A61K31/565 , A61K2300/00
摘要: Dosing regimen for transdermal delivery of hormones comprising a variable treatment cycle and a variable rest interval.
摘要翻译: 用于经皮递送激素的给药方案,包括可变治疗周期和可变休息间隔。
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公开(公告)号:US20140256690A1
公开(公告)日:2014-09-11
申请号:US14201153
申请日:2014-03-07
申请人: Arkady RUBIN , Maria FOEGH , Agis KYDONIEUS , Thomas M. ROSSI
发明人: Arkady RUBIN , Maria FOEGH , Agis KYDONIEUS , Thomas M. ROSSI
IPC分类号: A61K9/70 , A61K31/565 , A61K31/567
CPC分类号: A61K31/565 , A61K9/7061 , A61K31/567 , A61K2300/00
摘要: A transdermal drug delivery device for reducing the risk of pregnancy in overweight women is disclosed. Methods of using the device are also disclosed. When used in accordance with the disclosed methods, the probability that the device will be effective in overweight women is approximately equal to or greater than the probability that the device would be effective in the case of a woman who is not overweight.
摘要翻译: 公开了一种用于降低超重女性怀孕风险的透皮给药装置。 还公开了使用该装置的方法。 当根据所公开的方法使用时,设备在超重女性中有效的可能性大约等于或大于在不超重的女性的情况下该装置有效的概率。
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公开(公告)号:US07265097B2
公开(公告)日:2007-09-04
申请号:US10224173
申请日:2002-08-20
申请人: Agis Kydonieus , Clive Elson , Maya Thanou
发明人: Agis Kydonieus , Clive Elson , Maya Thanou
CPC分类号: A61K31/727 , A61K45/06 , A61K47/24 , A61K47/36 , A61K48/00
摘要: The present invention provides methods and compositions for delivering a therapeutic agent across a membrane that has limited permeability for the therapeutic agent. The method includes delivering the therapeutic agent to the membrane in a composition which includes a sulphated chitinous polymer as a primary carrier.
摘要翻译: 本发明提供了用于递送治疗剂的方法和组合物,所述方法和组合物跨越对治疗剂具有有限渗透性的膜。 该方法包括将治疗剂递送到包含硫酸化壳多糖聚合物作为主要载体的组合物中的膜上。
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公开(公告)号:US20050214255A1
公开(公告)日:2005-09-29
申请号:US10810742
申请日:2004-03-25
申请人: Clive Elson , Agis Kydonieus , Susan Henderson
发明人: Clive Elson , Agis Kydonieus , Susan Henderson
IPC分类号: A61K31/722 , A61K38/16 , A61K38/21 , C07K14/475 , C07K14/56 , C08B37/08
CPC分类号: C08B37/003 , A61K31/722 , A61K38/164 , A61K38/212
摘要: The invention pertains to N-acetylated, N, O-carboxyalkylchitosans and methods for using the chitosans to treat disorders, such as cancer, nervous system disorders, urinary tract disorders, and reproductive tract disorders.
摘要翻译: 本发明涉及N-乙酰化的N,O-羧基烷基壳多糖和使用壳聚糖治疗诸如癌症,神经系统疾病,尿路疾病和生殖道障碍的疾病的方法。
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公开(公告)号:US09198876B2
公开(公告)日:2015-12-01
申请号:US13123012
申请日:2009-10-07
申请人: Thomas M. Rossi , Marie Foegh , Agis Kydonieus
发明人: Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号: A61K9/70 , A61K31/565 , A61K31/57
CPC分类号: A61K31/57 , A61K9/7023 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/565 , A61K31/566 , A61K2300/00
摘要: Dosing regimen for transdermal delivery of hormones comprising a 28 day treatment cycle with a fixed treatment interval and a fixed rest interval.
摘要翻译: 用于经皮递送激素的给药方案,其包括具有固定治疗间隔和固定休息间隔的28天治疗周期。
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公开(公告)号:US20130116222A1
公开(公告)日:2013-05-09
申请号:US13667632
申请日:2012-11-02
IPC分类号: A61K31/567
CPC分类号: A61K31/567 , A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K31/57 , A61K47/12 , A61K47/20 , A61K47/32
摘要: A composition for transdermal delivery of a progestin for progestin hormone therapy is disclosed. Also disclosed is a transdermal delivery device comprising the composition. For progestin-only hormone therapy, the composition contains an anti-oxidant and does not contain an estrogen. For therapy involving a progestin and an estrogen, the composition contains the progestin, the estrogen and an additional anti-oxidant. Methods of improving the stability of progestin-containing compositions comprising oxidative agents are also disclosed. The methods comprise including one or more anti-oxidants in the compositions.
摘要翻译: 公开了用于孕激素治疗孕激素透皮递送的组合物。 还公开了包含该组合物的透皮递送装置。 对于仅孕激素治疗,该组合物含有抗氧化剂并且不含有雌激素。 对于涉及孕激素和雌激素的治疗,组合物含有孕激素,雌激素和另外的抗氧化剂。 还公开了改善含有孕激素的组合物包含氧化剂的稳定性的方法。 所述方法包括在组合物中包含一种或多种抗氧化剂。
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公开(公告)号:US20120215186A1
公开(公告)日:2012-08-23
申请号:US13463494
申请日:2012-05-03
IPC分类号: A61M35/00
CPC分类号: A61K9/7084 , A61K9/7061 , A61K31/56 , A61K31/57 , A61K2300/00
摘要: A transdermal drug delivery device is disclosed. Over an extended wear period, the device causes cumulative moderate irritation plus significant irritation of less than 5% and/or achieves a meaningful degree of detachment over a seven day period of less than 20%.
摘要翻译: 公开了一种透皮药物递送装置。 在延长的磨损期间,该装置导致累积的中度刺激加上显着的刺激小于5%和/或在小于20%的七天期间达到有意义的脱离程度。
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公开(公告)号:US20100178323A1
公开(公告)日:2010-07-15
申请号:US12687489
申请日:2010-01-14
CPC分类号: A61K9/7084 , A61K9/7061 , A61K31/56 , A61K31/57 , A61K2300/00
摘要: A transdermal drug delivery device is disclosed. Over an extended wear period, the device causes cumulative moderate irritation plus significant irritation of less than 5% and/or achieves a meaningful degree of detachment over a seven day period of less than 20%.
摘要翻译: 公开了一种透皮药物递送装置。 在延长的磨损期间,该装置导致累积的中度刺激加上显着的刺激小于5%和/或在小于20%的七天期间达到有意义的脱离程度。
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公开(公告)号:US07456267B2
公开(公告)日:2008-11-25
申请号:US10810742
申请日:2004-03-25
CPC分类号: C08B37/003 , A61K31/722 , A61K38/164 , A61K38/212
摘要: The invention pertains to N-acetylated, N, O-carboxyalkylchitosans and methods for using the chitosans to treat disorders, such as cancer, nervous system disorders, urinary tract disorders, and reproductive tract disorders.
摘要翻译: 本发明涉及N-乙酰化的N,O-羧基烷基壳多糖和使用壳聚糖治疗诸如癌症,神经系统疾病,尿路疾病和生殖道障碍的疾病的方法。
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