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公开(公告)号：US20050234242A1
公开(公告)日：2005-10-20
申请号：US11074194
申请日：2005-03-07
申请人： Ahmad Khodabocus , Guisheng Li , Zhi-Hui Lu , Frank Roschangar , Chris Senanayake , Ming Shen
发明人： Ahmad Khodabocus , Guisheng Li , Zhi-Hui Lu , Frank Roschangar , Chris Senanayake , Ming Shen
IPC分类号： C07D209/30 , C07D417/02 , C07D43/02 , C07D49/02
CPC分类号： C07D209/30
摘要： The present invention provides a process for making a compound of general formula I: wherein: R=H or C1-8alkyl X=C3-C8cycloalkyl, C3-C8aryl or C3-C8alkyl; Y=heteroaryl or aryl; Z=H, HO2C—, C1-8alkyl O2C—, C1-6alkyl HNC(O)—, and as described herein.
摘要翻译： 本发明提供制备通式I化合物的方法：其中：R = H或C 1-8烷基X = C 3 -C 8 C 3 -C 8环烷基，C 3 -C 8芳基或C 3 -C 8烷基; Y =杂芳基或芳基; Z = H，HO 2 C，C 1-8烷基，O 2 C，C 1-6，N， 烷基HNC（O） - ，并如本文所述。
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公开(公告)号：US07332614B2
公开(公告)日：2008-02-19
申请号：US11074194
申请日：2005-03-07
申请人： Ahmad Khodabocus , Guisheng Li , Zhi-Hui Lu , Frank Roschangar , Chris Hugh Senanayake , Ming Shen
发明人： Ahmad Khodabocus , Guisheng Li , Zhi-Hui Lu , Frank Roschangar , Chris Hugh Senanayake , Ming Shen
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30
摘要： The present invention provides a process for making a compound of general formula I: wherein: R=H or C1-8alkyl X=C3-C8cycloalkyl, C3-C8aryl or C3-C8alkyl; Y=heteroaryl or aryl; Z=H, HO2C—, C1-8alkyl O2C—, C1-6alkyl HNC(O)—, and as described herein.
摘要翻译： 本发明提供制备通式I化合物的方法：其中：R = H或C 1-8烷基X = C 3 -C 8 C 3 -C 8环烷基，C 3 -C 8芳基或C 3 -C 8烷基; Y =杂芳基或芳基; Z = H，HO 2 C，C 1-8烷基，O 2 C，C 1-6，N， 烷基HNC（O） - ，并如本文所述。
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公开(公告)号：US20060183752A1
公开(公告)日：2006-08-17
申请号：US11351411
申请日：2006-02-10
申请人： Ahmad Khodabocus , Zhi-Hui Lu , Chris Senanayake , Hanxun Wei , Yongda Zhang
发明人： Ahmad Khodabocus , Zhi-Hui Lu , Chris Senanayake , Hanxun Wei , Yongda Zhang
IPC分类号： A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/4184 , A61K31/404 , C07D409/02 , C07D403/02
CPC分类号： C07D209/10 , C07D209/08 , C07D209/12 , C07D401/04 , C07D403/04 , C07D409/04
摘要： Disclosed are processes for making 2,3 disubstituted indole compounds such as compounds of general formula I comprised of the steps of a) reacting a bromoindole compound (i) with a dialkoxyl C1-5 borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate; b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.
摘要翻译： 公开了制备2,3二取代吲哚化合物的方法，例如通式I的化合物，其包括以下步骤：a）在存在下使溴吲哚化合物（i）与二烷氧基C 1-5 - 的配体，钯催化剂和碱，以制备通式（ii）的化合物; 或者使化合物（i）与三烷基氧化镁试剂反应，然后用硼酸盐处理; b）使步骤a的产物与本文定义R 2 Hal的R 2-Hal反应。
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公开(公告)号：US07851625B2
公开(公告)日：2010-12-14
申请号：US12487910
申请日：2009-06-19
IPC分类号： C07D403/04 , C07D401/04 , C07D235/04 , C07D209/04
CPC分类号： C07D209/10 , C07D209/08 , C07D209/12 , C07D401/04 , C07D403/04 , C07D409/04
摘要： Disclosed are processes for making 2, 3 disubstituted indole compounds such as compounds of general formula I comprised of the steps of a) reacting a bromoindole compound (i) with a dialkoxyl C1-5 borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate; b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.
摘要翻译： 公开了制备2,3,4-二取代吲哚化合物的方法，例如通式I的化合物，其包括以下步骤：a）在配体，钯催化剂和钯催化剂存在下使溴吲哚化合物（i）与二烷氧基C1-5硼烷反应， 制备通式（ii）的化合物的碱; 或者使化合物（i）与三烷基氧化镁试剂反应，然后用硼酸盐处理; b）使步骤a的产物与本文定义R 2 Hal的R 2-Hal反应。
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公开(公告)号：US07642352B2
公开(公告)日：2010-01-05
申请号：US11351411
申请日：2006-02-10
IPC分类号： C07D403/04
CPC分类号： C07D209/10 , C07D209/08 , C07D209/12 , C07D401/04 , C07D403/04 , C07D409/04
摘要： Disclosed are processes for making 2,3 disubstituted indole compounds such as compounds of general formula I comprised of the steps of a) reacting a bromoindole compound (i) with a dialkoxyl C1-5 borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate; b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.
摘要翻译： 公开了制备2,3二取代的吲哚化合物的方法，例如通式I的化合物，其包括以下步骤：a）在配体，钯催化剂和钯催化剂存在下使溴吲哚化合物（i）与二烷氧基C1-5硼烷反应， 制备通式（ii）的化合物的碱; 或者使化合物（i）与三烷基氧化镁试剂反应，然后用硼酸盐处理; b）使步骤a的产物与本文定义R 2 Hal的R 2-Hal反应。
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![Process for making 5,11-Dihydro-11-ethyl-5-methyl-8{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one](/abs-image/US/2007/10/16/US07282583B2/abs.jpg.150x150.jpg)
6.发明授权Process for making 5,11-Dihydro-11-ethyl-5-methyl-8{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one 有权制备5,11-二氢-11-乙基-5-甲基-8（2 - {（1-氧代-4-喹啉基）氧基}乙基} -6H-二吡啶并[3,2-b：2' 3'-e] [1,4]二氮杂-6-酮公开(公告)号：US07282583B2
公开(公告)日：2007-10-16
申请号：US11560536
申请日：2006-11-16
申请人： Saeed Ahmad , Robert Frederick Boswell, Jr. , Jack Delbert Brown , Cary Mark Davis , Kai Oliver Donsbach , Bernard Franklin Gupton , Christopher Peter Johnson, III , Ahmad Khodabocus , Vithalanand R. Kulkarni , Young S. Lo
发明人： Saeed Ahmad , Robert Frederick Boswell, Jr. , Jack Delbert Brown , Cary Mark Davis , Kai Oliver Donsbach , Bernard Franklin Gupton , Christopher Peter Johnson, III , Ahmad Khodabocus , Vithalanand R. Kulkarni , Young S. Lo
IPC分类号： C07D471/14 , C07D215/16 , C07D211/72 , C07D211/84
CPC分类号： C07D471/14 , C07D213/80 , C07D401/12 , C07D401/14
摘要： An improved process for making 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one.
摘要翻译： 制备5,11-二氢-11-乙基-5-甲基-8- {2 - {（1-氧代-4-喹啉基）氧基}乙基} -6H-二吡啶并[3,2-b： 2'，3'-e] [1,4]二氮杂-6-酮。
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![Process for making 5,11-Dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2',3'-e][1,4]diazepin-6-one](/abs-image/US/2007/06/07/US20070129542A1/abs.jpg.150x150.jpg)
7.发明申请Process for making 5,11-Dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2',3'-e][1,4]diazepin-6-one 有权制备5,11-二氢-11-乙基-5-甲基-8- {2 - {（1-氧代-4-喹啉基）氧基}乙基} -6H-二吡啶并[3,2-b：2' ，3'-e] [1,4]二氮杂萘-6-酮公开(公告)号：US20070129542A1
公开(公告)日：2007-06-07
申请号：US11560536
申请日：2006-11-16
申请人： Saeed Ahmad , Robert Boswell , Jack Brown , Cary Davis , Kai Donsbach , Bernard Gupton , Christopher Johnson , Ahmad Khodabocus , Vithalanand Kulkarni , Young Lo
发明人： Saeed Ahmad , Robert Boswell , Jack Brown , Cary Davis , Kai Donsbach , Bernard Gupton , Christopher Johnson , Ahmad Khodabocus , Vithalanand Kulkarni , Young Lo
IPC分类号： C07D487/14
CPC分类号： C07D471/14 , C07D213/80 , C07D401/12 , C07D401/14
摘要： An improved process for making 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one.
摘要翻译： 制备5,11-二氢-11-乙基-5-甲基-8- {2 - {（1-氧代-4-喹啉基）氧基}乙基} -6H-二吡啶并[3,2-b： 2'，3'-e] [1,4]二氮杂-6-酮。
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