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    Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
    3.
    发明授权
    Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties 有权
    具有改进凝胶性能的各种三嵌段聚酯聚乙二醇共聚物的混合物

    公开(公告)号：US07018645B1

    公开(公告)日：2006-03-28

    申请号：US09559799

    申请日：2000-04-27

    申请人： Ai-Zhi Piao ,  Chung Shih

    发明人： Ai-Zhi Piao ,  Chung Shih

    IPC分类号： A61F2/00 ,  A61F13/00 ,  A61K9/48 ,  A61K9/20 ,  A61K9/22

    CPC分类号： A61K9/0024 ,  A61K47/34 ,  C08L67/04

    摘要： A water soluble, biodegradable reverse thermal gelation system comprising a mixture of at least two types of tri-block copolymer components is disclosed. The tri-block copolymer components are made of a hydrophobic biodegradable polyester A-polymer block and a hydrophilic polyethylene glycol B-polymer block. The drug release and gel matrix erosion rates of the biodegradable reverse thermal gelation system may be modulated by various parameters such as the hydrophobic/hydrophilic component contents, polymer block concentrations, molecular weights and gelation temperatures, and weight ratios of the tri-block copolymer components in the mixture.

    摘要翻译： 公开了包含至少两种类型的三嵌段共聚物组分的混合物的水溶性，可生物降解的逆热凝胶体系。 三嵌段共聚物组分由疏水性生物可降解聚酯A聚合物嵌段和亲水性聚乙二醇B-聚合物嵌段制成。 可生物降解的反向热凝胶化系统的药物释放和凝胶基质侵蚀速率可以通过各种参数调节，例如疏水/亲水组分含量，聚合物嵌段浓度，分子量和凝胶化温度以及三嵌段共聚物组分的重量比 在混合物中。

    PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
    4.
    发明授权
    PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water 有权
    PLA / PLGA低聚物与嵌段共聚物结合，以增加药物在水中的溶解度

    公开(公告)号：US06592899B2

    公开(公告)日：2003-07-15

    申请号：US09971082

    申请日：2001-10-03

    申请人： Kirk Dee Fowers ,  Gaylen M. Zentner ,  Chung Shih ,  Ai-Zhi Piao

    发明人： Kirk Dee Fowers ,  Gaylen M. Zentner ,  Chung Shih ,  Ai-Zhi Piao

    IPC分类号： A61K914

    CPC分类号： A61K47/34 ,  C08L67/04 ,  C08L2666/18

    摘要： Polymeric compositions having improved capability of solubilizing a drug in a hydrophilic environment to form a solution, comprising: a biodegradable polyester oligomer; and biodegradable AB-type, ABA-type, or BAB-type block copolymers are disclosed. The copolymers are comprised of about 50.1 to 65% by weight of a biodegradable, hydrophobic A polymer block comprising a biodegradable polyester, and about 35 to 49.9% by weight of a hydrophilic B polymer block comprising a polyethylene glycol (PEG), and wherein the block copolymer has a weight averaged molecular weight of between 2400 to 4999. The biodegradable polyester oligomer of said composition is within a range of 0.01% to 30% by weight of the total polymer mixture, and the content of the biodegradable AB-type, ABA-type, or BAB-type block copolymer is within a range of 70% to 99.99% by weight of the total polymer mixture.

    摘要翻译： 具有改善在亲水环境中溶解药物以形成溶液的能力的聚合物组合物，包括：可生物降解的聚酯低聚物; 并且公开了可生物降解的AB型，ABA型或BAB型嵌段共聚物。 共聚物由约50.1至65重量％的包含可生物降解聚酯的可生物降解的疏水性A聚合物嵌段和约35至49.9重量％的包含聚乙二醇（PEG）的亲水性B聚合物嵌段组成，并且其中 嵌段共聚物的重均分子量在2400至4999之间。所述组合物的可生物降解的聚酯低聚物在总聚合物混合物的重量的0.01％至30％的范围内，并且可生物降解的AB型，ABA的含量 型或BAB型嵌段共聚物在总聚合物混合物的70重量％至99.99重量％的范围内。

    Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
    7.
    发明授权
    Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof 有权
    由微粒和可生物降解的凝胶组成的具有改进的释放特征的药剂递送系统及其使用方法

    公开(公告)号：US06287588B1

    公开(公告)日：2001-09-11

    申请号：US09559507

    申请日：2000-04-27

    申请人： Chung Shih ,  Gaylen M. Zentner

    发明人： Chung Shih ,  Gaylen M. Zentner

    IPC分类号： A61F200

    CPC分类号： A61K47/34 ,  A61K9/06

    摘要： A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent-delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bio-active agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and/or controlled. In addition, a second agent may be loaded in some of the microparticles and/or the gel matrix.

    摘要翻译： 公开了以可控制的方式在生物环境中释放生物活性剂或药物的组合物和方法。 组合物是双相聚合物递送组合物，其包含连续的生物相容性凝胶相，包含限定的微粒的不连续颗粒相和待递送的试剂。 含有生物活性剂的微粒可释放地夹带在生物相容性聚合物凝胶基质内。 生物活性剂释放可以单独包含在微粒相中，也可以包含在微粒和凝胶基质中。 试剂的释放在一段时间内延长，并且递送可以被调节和/或控制。 另外，第二种试剂可以装载在一些微粒和/或凝胶基质中。

    BIODEGRADABLE BLOCK COPOLYMERIC COMPOSITIONS FOR DRUG DELIVERY
    10.
    发明申请
    BIODEGRADABLE BLOCK COPOLYMERIC COMPOSITIONS FOR DRUG DELIVERY 有权
    用于药物递送的可生物降解的嵌段共聚物组合物

    公开(公告)号：US20090264537A1

    公开(公告)日：2009-10-22

    申请号：US12490968

    申请日：2009-06-24

    申请人： Chung Shih ,  Gaylen M. Zentner

    发明人： Chung Shih ,  Gaylen M. Zentner

    IPC分类号： A61K47/34

    CPC分类号： A61K47/34 ,  A61K9/0024 ,  A61K31/765 ,  A61K31/77 ,  A61K47/10 ,  C08G2261/126 ,  C08L71/02 ,  C08L2666/18 ,  C08L2666/02

    摘要： An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems.

    摘要翻译： 公开了改进的药物递送组合物和使用方法。 组合物包含一种或多种可生物降解的嵌段共聚物药物载体; 和包含聚乙二醇（PEG），PEG衍生物或PEG和PEG衍生物的混合物的重构增强和使能剂。 组合物可以按照或在被溶解或快速重构在水性载体中以提供均匀的溶液或均匀的胶体体系来施用。