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    Reconstitutable reverse thermal gelling polymers
    2.
    发明授权
    Reconstitutable reverse thermal gelling polymers 有权
    可重构的反向热凝胶聚合物

    公开(公告)号：US09155722B2

    公开(公告)日：2015-10-13

    申请号：US12886387

    申请日：2010-09-20

    申请人： Kirk D. Fowers ,  Ramesh C. Rathi ,  Ai-Zhi Piao

    发明人： Kirk D. Fowers ,  Ramesh C. Rathi ,  Ai-Zhi Piao

    IPC分类号： A61K31/337 ,  A61K9/14 ,  A61K47/14

    CPC分类号： A61K31/337

    摘要： Biodegradable and bioabsorbable block copolymers, which can be in the form of solid powder or powder wax compositions that can be easily reconstituted into an aqueous polymer solution and exhibit reverse thermal gellation properties upon exposure to elevated temperatures, are provided. Methods of making using these copolymers are also provided.

    摘要翻译： 提供可生物降解和生物可吸收的嵌段共聚物，其可以是固体粉末或粉末蜡组合物的形式，其可以容易地重构成聚合物水溶液并且在暴露于高温下显示出反向热凝胶性质。 还提供使用这些共聚物的制备方法。

    RECONSTITUTABLE REVERSE THERMAL GELLING POLYMERS
    3.
    发明申请
    RECONSTITUTABLE REVERSE THERMAL GELLING POLYMERS 有权
    可重复反转的热凝胶聚合物

    公开(公告)号：US20110071216A1

    公开(公告)日：2011-03-24

    申请号：US12886387

    申请日：2010-09-20

    申请人： Kirk D. FOWERS ,  Ramesh C. RATHI ,  Ai-Zhi PIAO

    发明人： Kirk D. FOWERS ,  Ramesh C. RATHI ,  Ai-Zhi PIAO

    IPC分类号： A61K31/337 ,  A61P35/00

    CPC分类号： A61K31/337

    摘要： Biodegradable and bioabsorbable block copolymers, which can be in the form of solid powder or powder wax compositions that can be easily reconstituted into an aqueous polymer solution and exhibit reverse thermal gellation properties upon exposure to elevated temperatures, are provided. Methods of making using these copolymers are also provided.

    摘要翻译： 提供可生物降解和生物可吸收的嵌段共聚物，其可以是固体粉末或粉末蜡组合物的形式，其可以容易地重构成聚合物水溶液并且在暴露于高温下显示出反向热凝胶性质。 还提供使用这些共聚物的制备方法。

    Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
    4.
    发明授权
    Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties 有权
    具有改进凝胶性能的各种三嵌段聚酯聚乙二醇共聚物的混合物

    公开(公告)号：US07018645B1

    公开(公告)日：2006-03-28

    申请号：US09559799

    申请日：2000-04-27

    申请人： Ai-Zhi Piao ,  Chung Shih

    发明人： Ai-Zhi Piao ,  Chung Shih

    IPC分类号： A61F2/00 ,  A61F13/00 ,  A61K9/48 ,  A61K9/20 ,  A61K9/22

    CPC分类号： A61K9/0024 ,  A61K47/34 ,  C08L67/04

    摘要： A water soluble, biodegradable reverse thermal gelation system comprising a mixture of at least two types of tri-block copolymer components is disclosed. The tri-block copolymer components are made of a hydrophobic biodegradable polyester A-polymer block and a hydrophilic polyethylene glycol B-polymer block. The drug release and gel matrix erosion rates of the biodegradable reverse thermal gelation system may be modulated by various parameters such as the hydrophobic/hydrophilic component contents, polymer block concentrations, molecular weights and gelation temperatures, and weight ratios of the tri-block copolymer components in the mixture.

    摘要翻译： 公开了包含至少两种类型的三嵌段共聚物组分的混合物的水溶性，可生物降解的逆热凝胶体系。 三嵌段共聚物组分由疏水性生物可降解聚酯A聚合物嵌段和亲水性聚乙二醇B-聚合物嵌段制成。 可生物降解的反向热凝胶化系统的药物释放和凝胶基质侵蚀速率可以通过各种参数调节，例如疏水/亲水组分含量，聚合物嵌段浓度，分子量和凝胶化温度以及三嵌段共聚物组分的重量比 在混合物中。

    PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
    5.
    发明授权
    PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water 有权
    PLA / PLGA低聚物与嵌段共聚物结合，以增加药物在水中的溶解度

    公开(公告)号：US06592899B2

    公开(公告)日：2003-07-15

    申请号：US09971082

    申请日：2001-10-03

    申请人： Kirk Dee Fowers ,  Gaylen M. Zentner ,  Chung Shih ,  Ai-Zhi Piao

    发明人： Kirk Dee Fowers ,  Gaylen M. Zentner ,  Chung Shih ,  Ai-Zhi Piao

    IPC分类号： A61K914

    CPC分类号： A61K47/34 ,  C08L67/04 ,  C08L2666/18

    摘要： Polymeric compositions having improved capability of solubilizing a drug in a hydrophilic environment to form a solution, comprising: a biodegradable polyester oligomer; and biodegradable AB-type, ABA-type, or BAB-type block copolymers are disclosed. The copolymers are comprised of about 50.1 to 65% by weight of a biodegradable, hydrophobic A polymer block comprising a biodegradable polyester, and about 35 to 49.9% by weight of a hydrophilic B polymer block comprising a polyethylene glycol (PEG), and wherein the block copolymer has a weight averaged molecular weight of between 2400 to 4999. The biodegradable polyester oligomer of said composition is within a range of 0.01% to 30% by weight of the total polymer mixture, and the content of the biodegradable AB-type, ABA-type, or BAB-type block copolymer is within a range of 70% to 99.99% by weight of the total polymer mixture.

    摘要翻译： 具有改善在亲水环境中溶解药物以形成溶液的能力的聚合物组合物，包括：可生物降解的聚酯低聚物; 并且公开了可生物降解的AB型，ABA型或BAB型嵌段共聚物。 共聚物由约50.1至65重量％的包含可生物降解聚酯的可生物降解的疏水性A聚合物嵌段和约35至49.9重量％的包含聚乙二醇（PEG）的亲水性B聚合物嵌段组成，并且其中 嵌段共聚物的重均分子量在2400至4999之间。所述组合物的可生物降解的聚酯低聚物在总聚合物混合物的重量的0.01％至30％的范围内，并且可生物降解的AB型，ABA的含量 型或BAB型嵌段共聚物在总聚合物混合物的70重量％至99.99重量％的范围内。