公开(公告)号：US06998137B2

公开(公告)日：2006-02-14

申请号：US09827100

申请日：2001-04-05

申请人： Chung Shih ,  Gaylen Zentner ,  Ai-Zhi Piao

发明人： Chung Shih ,  Gaylen Zentner ,  Ai-Zhi Piao

IPC分类号： A61F2/00 ,  A61F9/14 ,  A61F9/50 ,  A61F47/30 ,  A61K31/74 ,  A61K38/00

CPC分类号： A61K9/143 ,  A61K9/145 ,  A61K9/19

摘要： The present invention relates to compositions and methods for the modulated release of one or more proteins or peptides. The composition is comprised of a biocompatible polymeric matrix, a protein and/or peptide, and a sparingly water-soluble or essentially insoluble particle. The protein is deposited by adsorption or some other mechanism onto the sparingly water-soluble biocompatible particle wherein the protein-particle combination is dispersed within the polymeric matrix. The deposition of the protein onto the particle acts to modulate the release of the protein or peptide from dosage forms including long-acting dosage systems.

公开(公告)号：US20070249640A1

公开(公告)日：2007-10-25

申请号：US11681654

申请日：2007-03-02

申请人： Gaylen Zentner ,  Chung Shih ,  James McRea

发明人： Gaylen Zentner ,  Chung Shih ,  James McRea

IPC分类号： A61K31/517

CPC分类号： A61K31/517 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/44

摘要： The present invention relates to pharmaceutical compositions and dosage compositions of compounds, including injectable formulations for the parenteral delivery of such compounds into patients in need of such treatment. Also featured are methods of making and using the compositions, including methods for the treatment of neoplastic diseases.

公开(公告)号：US06589549B2

公开(公告)日：2003-07-08

申请号：US09906041

申请日：2001-07-13

申请人： Chung Shih ,  Gaylen Zentner

发明人： Chung Shih ,  Gaylen Zentner

IPC分类号： A61F200

CPC分类号： A61K9/0024 ,  A61K9/06 ,  A61K9/1647 ,  A61K47/34

摘要： A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent—delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bioactive agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and/or controlled. In addition, a second agent may be loaded in some of the microparticles and/or the gel matrix.

公开(公告)号：US20070259901A1

公开(公告)日：2007-11-08

申请号：US11733591

申请日：2007-04-10

申请人： Gaylen Zentner ,  Chung Shih ,  James McRea

发明人： Gaylen Zentner ,  Chung Shih ,  James McRea

IPC分类号： A61K31/517 ,  A61P35/00

CPC分类号： A61K31/517 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/44

摘要： The present invention relates to pharmaceutical compositions and dosage compositions of compounds, including injectable formulations for the parenteral delivery of such compounds into patients in need of such treatment. Also featured are methods of making and using the compositions, including methods for the treatment of neoplastic diseases.

摘要翻译： 本发明涉及化合物的药物组合物和剂量组合物，包括用于将这些化合物胃肠外递送给需要这种治疗的患者的可注射制剂。 还特征在于制备和使用组合物的方法，包括治疗肿瘤疾病的方法。

公开(公告)号：US20070249632A1

公开(公告)日：2007-10-25

申请号：US11692655

申请日：2007-03-28

申请人： Gaylen Zentner ,  Chung Shih ,  James McRea

发明人： Gaylen Zentner ,  Chung Shih ,  James McRea

IPC分类号： A61K31/517 ,  C07D239/72

CPC分类号： A61K31/517 ,  A61K9/0019 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  Y02A50/465

摘要： The present invention relates to pharmaceutical compositions and dosage compositions of compounds, including injectable formulations for the parenteral delivery of such compounds into patients in need of such treatment. Also featured are methods of making and using the compositions, including methods for the treatment of neoplastic diseases.

公开(公告)号：US20070042034A1

公开(公告)日：2007-02-22

申请号：US11491771

申请日：2006-07-24

申请人： Gaylen Zentner ,  James McRea ,  Mark Williams ,  Gregory Oehrtman ,  Tracy Powers

发明人： Gaylen Zentner ,  James McRea ,  Mark Williams ,  Gregory Oehrtman ,  Tracy Powers

IPC分类号： A61K9/48 ,  A61K9/20 ,  A61K31/192

CPC分类号： A61K9/2077 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/192

摘要： The invention relates to high drug load formulations containing (R)-2-(2-fluoro-4-biphenylyl)propionic acid as an active pharmaceutical ingredient.

摘要翻译： 本发明涉及含有（R）-2-（2-氟-4-联苯基）丙酸作为活性药物成分的高药物负荷制剂。

公开(公告)号：US20060159657A1

公开(公告)日：2006-07-20

申请号：US11386156

申请日：2006-03-21

申请人： Kirk Fowers ,  Gaylen Zentner ,  Miroslav Baudys ,  Maria Jurek ,  Wolfram Samlowski

发明人： Kirk Fowers ,  Gaylen Zentner ,  Miroslav Baudys ,  Maria Jurek ,  Wolfram Samlowski

IPC分类号： A61K38/20 ,  A61K9/14

CPC分类号： A61K38/2013 ,  A61K9/0019 ,  A61K9/0024 ,  A61K47/10 ,  A61K47/34 ,  C08G63/664 ,  C08G2261/126 ,  C08L71/02 ,  C08L2203/02

摘要： Therapeutic formulations comprising an effective amount of IL-2 or other lymphokine and a biodegradable polymeric carrier having reverse gelation properties and the methods of use thereof for local or both local and systemic control of proliferative cell disorders is disclosed. The formulation can be administered intratumorally/peritumorally and forms an IL-2 containing depot. The IL-2-containing depot provides for continuous, prolonged release of IL-2 sufficient to stimulate the production of cytotoxic T lymphocytes which function both locally and systemically, without causing unacceptable side effects.

摘要翻译： 公开了包含有效量的IL-2或其它淋巴因子和具有反向凝胶化特性的可生物降解的聚合物载体的治疗剂型及其用于局部或局部和全身控制增殖性细胞病症的方法。 该制剂可以肿瘤内/周围给药并形成含IL-2的贮库。 含IL-2的贮存库提供足够的IL-2连续延长释放，以足以刺激局部和全身功能的细胞毒性T淋巴细胞的产生，而不引起不可接受的副作用。

公开(公告)号：US5211951A

公开(公告)日：1993-05-18

申请号：US734843

申请日：1991-07-24

申请人： Randall V. Sparer ,  Gaylen Zentner

发明人： Randall V. Sparer ,  Gaylen Zentner

IPC分类号： A61K47/32 ,  A61K9/00 ,  A61K9/20 ,  A61K47/34 ,  C08G2/30 ,  C08G4/00

CPC分类号： A61K9/0024 ,  A61K9/2009 ,  A61K9/204 ,  C08G2/30 ,  C08G4/00

摘要： A process for the manufacture of bioerodible poly(ortho ester)s and polyacetals containing beneficial agents having a hydroxyl functionality of two or more and their fabrication into controlled release dosage forms having a reproducible delivery of the beneficial agent into the biological environment of use are disclosed.