公开(公告)号：US20140045824A1

公开(公告)日：2014-02-13

申请号：US14113239

申请日：2012-04-20

申请人： Akinori Goto ,  Mamoru Fukuda

发明人： Akinori Goto ,  Mamoru Fukuda

IPC分类号： C07D473/08 ,  C07D223/26

CPC分类号： C07D473/08 ,  C07B63/00 ,  C07D223/26 ,  C07D487/04

摘要： The present invention relates to a method for producing a complex crystal composed of two or more different compounds, comprising crystallizing the two or more different compounds under a condition at which menthol is heat melted, and a method for screening a complex crystal. In accordance with the method for producing a complex crystal of the present invention, a complex crystal capable of being used as a drug material can be produced rapidly, simply and efficiently. In addition, in accordance with the method for screening a complex crystal of the present invention, a stable complex crystal can be searched, which is industrially useful.

摘要翻译： 本发明涉及一种由两种或更多种不同化合物组成的复合晶体的制造方法，包括在薄荷醇被热熔融的条件下使两种或更多种不同的化合物结晶，以及筛选复合结晶的方法。 根据本发明的复合结晶的制造方法，可以快速，简单，有效地制造能够作为药物材料使用的复合结晶。 此外，根据本发明的复合晶体的筛选方法，可以搜索在工业上有用的稳定的复合晶体。

公开(公告)号：US09382250B2

公开(公告)日：2016-07-05

申请号：US14113239

申请日：2012-04-20

申请人： Akinori Goto ,  Mamoru Fukuda

发明人： Akinori Goto ,  Mamoru Fukuda

IPC分类号： C07B63/00 ,  C07D223/26 ,  C07D473/08 ,  C07D487/04

CPC分类号： C07D473/08 ,  C07B63/00 ,  C07D223/26 ,  C07D487/04

摘要： The present invention relates to a method for producing a complex crystal composed of two or more different compounds, comprising crystallizing the two or more different compounds under a condition at which menthol is heat melted, and a method for screening a complex crystal. In accordance with the method for producing a complex crystal of the present invention, a complex crystal capable of being used as a drug material can be produced rapidly, simply and efficiently. In addition, in accordance with the method for screening a complex crystal of the present invention, a stable complex crystal can be searched, which is industrially useful.

摘要翻译： 本发明涉及一种由两种或更多种不同化合物组成的复合晶体的制造方法，包括在薄荷醇被热熔融的条件下使两种或更多种不同的化合物结晶，以及筛选复合结晶的方法。 根据本发明的复合结晶的制造方法，可以快速，简单，有效地制造能够作为药物材料使用的复合结晶。 此外，根据本发明的复合晶体的筛选方法，可以搜索在工业上有用的稳定的复合晶体。

公开(公告)号：US20120100212A1

公开(公告)日：2012-04-26

申请号：US13382666

申请日：2010-07-05

申请人： Mamoru Fukuda ,  Akinori Goto

发明人： Mamoru Fukuda ,  Akinori Goto

IPC分类号： A61K9/36 ,  A61K9/22

CPC分类号： A61K9/0065 ,  A61K9/2072 ,  A61K9/2095

摘要： A water floatable tablet, which is either: (a) a tablet comprising at least one filler selected from the group consisting of a sugar alcohol, a sugar, a cellulose derivative, and a starch and a component which exhibits a hydrophobic effect, wherein the tablet has a hollow cavity in a center section; or (b) a tablet obtained by a process including: (1) forming a crust comprising at least one filler selected from the group consisting of a sugar alcohol, a sugar, a cellulose derivative, and a starch on an outer surface of a core comprising a sublimation solid, to obtain a dry coated tablet having the core positioned at a center section; (2) heating the dry coated tablet, to obtain a tablet having a hollow cavity; and (3) contacting the tablet having a hollow cavity with a component which exhibits a hydrophobic effect.

摘要翻译： 一种可漂浮浮片，其为：（a）包含至少一种选自糖醇，糖，纤维素衍生物和淀粉的填料的片剂和显示疏水作用的成分，其中， 片剂在中心部分具有中空腔; 或（b）通过以下方法获得的片剂：（1）在芯的外表面上形成包含至少一种选自糖醇，糖，纤维素衍生物和淀粉的填料的外皮 包括升华固体，以获得具有位于中心部分的芯的干涂片剂; （2）加热干燥的包衣片，得到具有中空腔的片剂; 和（3）使具有中空腔的片剂与显示疏水作用的成分接触。

公开(公告)号：US08101797B2

公开(公告)日：2012-01-24

申请号：US12613568

申请日：2009-11-06

申请人： Yoshiyuki Koizumi ,  Akinori Goto ,  Takushi Azemi

发明人： Yoshiyuki Koizumi ,  Akinori Goto ,  Takushi Azemi

IPC分类号： C07C323/03

CPC分类号： C07C319/20 ,  C07C319/28 ,  C07C323/58

摘要： A process for producing methionine advantageously in view of cost, while efficiently recovering useful components, is provided including the following steps: (1) hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound; (2) introducing carbon dioxide into the reaction solution obtained in the step (1) to thereby precipitate methionine, and separating the resulting slurry into a precipitate and a mother liquor; (3) concentrating the mother liquor obtained in the step (2), mixing the resulting concentrate with a lower alcohol, introducing carbon dioxide into the resulting mixture to thereby precipitate methionine and potassium hydrogencarbonate, and separating the resulting slurry into a precipitate and a mother liquor; and (4) concentrating the mother liquor obtained in the step (3), treating the resulting concentrate by heating at a temperature of from 150 to 200° C., and recycling the treated solution for use in step (2).

摘要翻译： 提供有益于成本考虑成本有效回收有用成分的方法，包括以下步骤：（1）水解5- [2-（甲硫基）乙基]咪唑烷-2,4-二酮在 碱性钾化合物; （2）将二氧化碳引入到步骤（1）中得到的反应溶液中，从而使甲硫氨酸沉淀，并将得到的浆料分离成沉淀物和母液; （3）浓缩步骤（2）中获得的母液，将所得浓缩物与低级醇混合，将二氧化碳引入所得混合物中，从而沉淀甲硫氨酸和碳酸氢钾，并将所得浆液分离成沉淀物和母体 酒; 和（4）浓缩步骤（3）中得到的母液，在150〜200℃的温度下加热处理所得浓缩物，并循环使用步骤（2）中处理的溶液。

公开(公告)号：US08217197B2

公开(公告)日：2012-07-10

申请号：US12613575

申请日：2009-11-06

申请人： Yoshiyuki Koizumi ,  Akinori Goto ,  Takushi Azemi

发明人： Yoshiyuki Koizumi ,  Akinori Goto ,  Takushi Azemi

IPC分类号： C07C323/00

CPC分类号： C07C319/28 ,  C07C319/20 ,  C07C323/58

摘要： A process for producing methionine advantageously in view of cost, while efficiently recovering useful components, is provided, including the following steps (1) hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound; (2) introducing carbon dioxide into the reaction solution obtained in step (1) to thereby precipitate methionine, and separating the resulting slurry into a precipitate and a mother liquor; (3) concentrating the mother liquor obtained in step (2), mixing the resulting concentrate with a lower alcohol, introducing carbon dioxide into the resulting mixture to thereby precipitate methionine and potassium hydrogencarbonate, and separating the resulting slurry into a precipitate and a mother liquor; and (4) concentrating the mother liquor obtained in step (3), treating the resulting concentrate by heating at a temperature of from 150 to 200° C., and recycling the treated solution for use in step (3).

摘要翻译： 提供了有利于成本考虑成本有效回收有用成分的方法，包括以下步骤（1）在5-（2-甲硫基）乙基]咪唑烷-2,4-二酮在 碱性钾化合物; （2）将二氧化碳引入到步骤（1）中获得的反应溶液中，从而使甲硫氨酸沉淀，并将所得浆液分离成沉淀物和母液; （3）浓缩步骤（2）中获得的母液，将得到的浓缩物与低级醇混合，将二氧化碳引入所得混合物中，从而沉淀甲硫氨酸和碳酸氢钾，并将所得浆料分离成沉淀物和母液 ; （4）浓缩步骤（3）中得到的母液，在150〜200℃的温度下加热处理得到的浓缩物，并循环处理后的步骤（3）中使用的溶液。

公开(公告)号：US20100004486A1

公开(公告)日：2010-01-07

申请号：US12480283

申请日：2009-06-08

申请人： Yoshiyuki KOIZUMI ,  Akinori Goto ,  Takushi Azemi

发明人： Yoshiyuki KOIZUMI ,  Akinori Goto ,  Takushi Azemi

IPC分类号： C07C319/02

CPC分类号： C07C319/20 ,  C07C319/28 ,  C07C323/58

摘要： The present invention provides a process for producing methionine which is advantageous from the viewpoints of cost and wastewater disposal, and which comprises the following steps (1) to (5):(1) a reaction step comprising hydrolysis of 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound; (2) a first crystallization step comprising introduction of carbon dioxide into the reaction solution obtained in the step (1) to precipitate methionine, and separation of the resultant slurry into a precipitate and a mother liquor; (3) a second crystallization step comprising concentration of the mother liquor obtained in the step (2), mixing with a lower alcohol, introduction of carbon dioxide into the mixture to precipitate methionine and potassium hydrogen carbonate, and separation of the resultant slurry into a precipitate and a mother liquor; (4) a heating step comprising concentration of the mother liquor obtained in the step (3) followed by a heating treatment at 150 to 200° C.; and (5) a third crystallization step comprising introduction of carbon dioxide into the heated mother liquor obtained in the step (4) to precipitate methionine and potassium hydrogen carbonate, and separation of the resultant slurry into a precipitate and a mother liquor.

摘要翻译： 本发明提供了从成本和废水处理的观点出发，优选甲硫氨酸的方法，其包括以下步骤（1）至（5）：（1）包括5- [2-（ 甲基硫基）乙基]咪唑烷-2,4-二酮在碱性钾化合物的存在下反应; （2）第一结晶步骤，包括将二氧化碳引入到步骤（1）中获得的反应溶液中以沉淀甲硫氨酸，并将所得浆料分离成沉淀物和母液; （3）第二结晶步骤，其包括浓缩步骤（2）中得到的母液，与低级醇混合，将二氧化碳引入混合物中以沉淀甲硫氨酸和碳酸氢钾，并将所得浆液分离成 沉淀和母液; （4）加热步骤，包括浓缩步骤（3）中获得的母液，然后在150至200℃下进行加热处理; 和（5）第三结晶步骤，包括将二氧化碳引入步骤（4）中获得的加热母液中以沉淀甲硫氨酸和碳酸氢钾，并将所得浆料分离成沉淀物和母液。