公开(公告)号：US5623069A

公开(公告)日：1997-04-22

申请号：US437984

申请日：1995-05-10

申请人： Akira Haze ,  Hiroyuki Hatano ,  Tomomi Ikemoto ,  Yoshifumi Kitamoto

发明人： Akira Haze ,  Hiroyuki Hatano ,  Tomomi Ikemoto ,  Yoshifumi Kitamoto

IPC分类号： C07D20060101 ,  C07H1/02 ,  C07H19/04 ,  C07H19/10 ,  C07H19/20 ,  C07H19/207 ,  C07H1/00 ,  C07H19/06 ,  C07H19/16

CPC分类号： C07H19/04

摘要： A method of producing 5'-nucleotide, which comprises maintaining a nucleoside suspension in an organic solvent at a temperature not lower than about 20.degree. C., and then subjecting the resultant suspension to a phosphorylatipon of the nucleoside(s).According to the present invention, 5'-nucleotide can be produced from a nucleoside at high purity and high yield in a shortened reaction time, and impurity removal in the nucleotide purification process is easily accomplished.

摘要翻译： 一种生产5'-核苷酸的方法，其包括在不低于约20℃的温度下将核苷悬浮液保持在有机溶剂中，然后使所得悬浮液经受核苷的磷酸化。 根据本发明，在缩短的反应时间内可以以高纯度和高产率从核苷生产5'-核苷酸，并且容易实现核苷酸纯化过程中的杂质去除。