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公开(公告)号：US07700709B2
公开(公告)日：2010-04-20
申请号：US11919912
申请日：2006-04-27
IPC分类号： C08G61/12
CPC分类号： C08G73/0233 , A61K47/60 , A61K47/645 , C08G65/329 , C08G65/3332 , C08G73/028
摘要： A derivative of a cytidine metabolic antagonist which can exert a high therapeutic effect at a low dose. A polymeric derivative of a cytidine metabolic antagonist which comprises a polymeric compound having a polyethylene glycol moiety and a polymer moiety having a carboxyl group in a side chain and a cytidine metabolic antagonist, which has such a structure that the carboxyl group in the side chain of the polymeric compound and an amino group in the cytidine metabolic antagonist are bound together to form an amide bond.
摘要翻译： 胞苷代谢拮抗剂的衍生物，其可以在低剂量下发挥高治疗效果。 胞苷代谢拮抗剂的聚合衍生物，其包含具有聚乙二醇部分的聚合化合物和在侧链具有羧基的聚合物部分和胞苷代谢拮抗剂，其具有以下结构：侧链中的羧基 胞苷代谢拮抗剂中的高分子化合物和氨基结合在一起形成酰胺键。
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公开(公告)号：US20090012252A1
公开(公告)日：2009-01-08
申请号：US11919912
申请日：2006-04-27
IPC分类号： C08G83/00
CPC分类号： C08G73/0233 , A61K47/60 , A61K47/645 , C08G65/329 , C08G65/3332 , C08G73/028
摘要： [PROBLEMS] To provide a derivative of a cytidine metabolic antagonist which can exert a high therapeutic effect at a low dose.[MEANS FOR SOLVING PROBLEMS] A polymeric derivative of a cytidine metabolic antagonist which comprises a polymeric compound having a polyethylene glycol moiety and a polymer moiety having a carboxyl group in a side chain and a cytidine metabolic antagonist, which has such a structure that the carboxyl group in the side chain of the polymeric compound and an amino group in the cytidine metabolic antagonist are bound together to form an amide bond.
摘要翻译： [问题]提供可以以低剂量发挥高治疗效果的胞苷代谢拮抗剂的衍生物。 解决问题的手段胞苷代谢拮抗剂的聚合衍生物包含具有聚乙二醇部分和侧链中具有羧基的聚合物部分和胞苷代谢拮抗剂的聚合物，其具有以下结构：羧基 聚合化合物的侧链基团和胞苷代谢拮抗剂中的氨基结合在一起形成酰胺键。
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公开(公告)号：US08323669B2
公开(公告)日：2012-12-04
申请号：US12225230
申请日：2007-03-22
申请人： Masayuki Kitagawa , Keizou Ishikawa , Takeshi Onda
发明人： Masayuki Kitagawa , Keizou Ishikawa , Takeshi Onda
CPC分类号： C08G65/33324 , A61K31/337 , A61K47/60 , A61K47/645 , C08G65/329 , C08G69/10 , C08G69/40 , C08G69/48 , C08L2203/02
摘要： [Problems] To provide a novel taxane derivative which can release the medicinal substance in a bioenzyme-independent manner, is expected to have an effective therapeutic efficacy, and has a water-solubility.[Means for Solving Problems] Disclosed is a polymer conjugate of a taxane, which comprises a polymer having a polyethylene glycol moiety and two or more succinic acid monoamide moieties and a taxane, wherein a carboxylate group in the polymer and an alcoholic hydroxyl group in the taxane are bound to each other via an ester bonding.
摘要翻译： [问题]为了提供能够以不依赖生物酶的方式释放药物的新型紫杉烷衍生物，预期具有有效的治疗功效，并且具有水溶性。 解决问题的手段公开了紫杉烷的聚合物缀合物，其包含具有聚乙二醇部分和两个或多个琥珀酸单酰胺部分的聚合物和紫杉烷，其中聚合物中的羧酸酯基团和 紫杉烷通过酯键相互结合。
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公开(公告)号：US07886932B2
公开(公告)日：2011-02-15
申请号：US12133073
申请日：2008-06-04
IPC分类号： G07F11/00
CPC分类号： G07F11/42
摘要： A vending machine has a support part that has a first support member extending in the right and left direction on the inside of a commodity storage chamber and a second support member extending in the front and rear direction on the inside of the commodity storage chamber, and supports a commodity column so that the commodity column is movable in the front and rear direction on the first and second support members. In the vending machine, when a support receiving part is detached from the first support member, the commodity column can be moved in the front and rear direction via the second support member, so that replenishment of commodities to the commodity column and maintenance of the commodity column can be accomplished. Both of the first support member and the second support members are located under the commodity column, and support the commodity column from the downside. Therefore, spaces for arranging support members at the right and left of the commodity column are unnecessary.
摘要翻译： 自动贩卖机具有支撑部，该支撑部具有在商品储存室的内侧上沿左右方向延伸的第一支撑部件和在商品收纳室的内侧沿前后方向延伸的第二支撑部件， 支撑商品列，使得商品列能够在第一和第二支撑构件上沿前后方向移动。 在自动售货机中，当支撑件接收部分与第一支撑件分离时，商品列可以经由第二支撑构件在前后方向上移动，从而向商品列补充商品并维持商品 柱可以完成。 第一支撑构件和第二支撑构件都位于商品栏下方，并且从下方支撑商品栏。 因此，不需要在商品栏的右侧和左侧安排支撑构件的空间。
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公开(公告)号：US20080302813A1
公开(公告)日：2008-12-11
申请号：US12133073
申请日：2008-06-04
IPC分类号： G07F11/00
CPC分类号： G07F11/42
摘要： A vending machine has a support part that has a first support member extending in the right and left direction on the inside of a commodity storage chamber and a second support member extending in the front and rear direction on the inside of the commodity storage chamber, and supports a commodity column so that the commodity column is movable in the front and rear direction on the first and second support members. In the vending machine, when a support receiving part is detached from the first support member, the commodity column can be moved in the front and rear direction via the second support member, so that replenishment of commodities to the commodity column and maintenance of the commodity column can be accomplished. Both of the first support member and the second support members are located under the commodity column, and support the commodity column from the downside. Therefore, spaces for arranging support members at the right and left of the commodity column are unnecessary.
摘要翻译： 自动贩卖机具有支撑部，该支撑部具有在商品储存室的内侧上沿左右方向延伸的第一支撑部件和在商品收纳室的内侧沿前后方向延伸的第二支撑部件， 支撑商品列，使得商品列能够在第一和第二支撑构件上沿前后方向移动。 在自动售货机中，当支撑件接收部分与第一支撑件分离时，商品列可以经由第二支撑构件在前后方向上移动，从而向商品列补充商品并维持商品 柱可以完成。 第一支撑构件和第二支撑构件都位于商品栏下方，并且从下方支撑商品栏。 因此，不需要在商品栏的右侧和左侧安排支撑构件的空间。
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公开(公告)号：US20080283545A1
公开(公告)日：2008-11-20
申请号：US12121680
申请日：2008-05-15
IPC分类号： B65H3/32
CPC分类号： G07F11/04 , G07F11/165
摘要： The present invention provides a commodity carrying out device that can reliably carry out a vertically-long shaped commodity in an upright state from a commodity storage column to a bucket. More specifically, since a commodity positioned at the front end side of a commodity storage column is tilted forward to be moved into a bucket, when moving a vertically-long shaped commodity in an upright state into a bucket, it is possible to move the commodity without the commodity toppling backwards. Thus, the commodity can be reliably moved into the bucket.
摘要翻译： 本发明提供一种商品执行装置，其能够从商品储存塔到桶可靠地执行直立状态的垂直长形状的商品。 更具体地说，由于位于商品储存塔的前端侧的商品向前倾斜以移动到桶中，因此当垂直状态的商品以直立状态移动到桶中时，可以移动商品 没有商品倒塌。 因此，商品可以可靠地移动到桶中。
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公开(公告)号：US20070169640A1
公开(公告)日：2007-07-26
申请号：US11624607
申请日：2007-01-18
申请人： Takeshi Sato , Takashi Nagasawa , Takeshi Onda
发明人： Takeshi Sato , Takashi Nagasawa , Takeshi Onda
IPC分类号： A23N1/00
CPC分类号： A47J31/3638 , A47J31/36 , A47J31/3609 , A47J31/3614 , A47J31/3619 , A47J31/3633
摘要： The invention provides a beverage extractor permitting extraction of a beverage of high quality irrespective of its type. The extractor is provided with a first extraction channel for letting the beverage extracted in a cylinder flow into the extraction pipe via beverage outlet holes of a second piston having a prescribed first bore and a second extraction channel via a communication hole having a prescribed second bore, which is smaller in bore than the outlet holes, for letting the beverage extracted in the cylinder flow into the extraction pipe, and the first and second extraction channels are switched over between each other by the movement of the second piston. This makes it possible to select an extraction channel suitable for the type of beverage, whether regular coffee or espresso coffee, and accordingly to extract a beverage of high quality irrespective of the type of beverage.
摘要翻译： 本发明提供一种饮料提取器，其允许提取高品质的饮料，而不管其类型如何。 提取器设置有第一提取通道，用于通过具有规定的第二孔的连通孔，将经气瓶抽取的饮料通过具有规定的第一孔的第二活塞和第二提取通道的饮料出口孔流入提取管， 其中孔径比出口孔小，用于使在汽缸中提取的饮料流入萃取管，并且第一和第二提取通道通过第二活塞的运动而在彼此之间切换。 这使得可以选择适合于饮料类型的提取通道，无论是常规咖啡还是咖啡浓缩咖啡，并且因此提取高质量的饮料，而与饮料类型无关。
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公开(公告)号：US20100234537A1
公开(公告)日：2010-09-16
申请号：US12225230
申请日：2007-03-22
申请人： Masayuki Kitagawa , Keizou Ishikawa , Takeshi Onda
发明人： Masayuki Kitagawa , Keizou Ishikawa , Takeshi Onda
IPC分类号： C08G69/48
CPC分类号： C08G65/33324 , A61K31/337 , A61K47/60 , A61K47/645 , C08G65/329 , C08G69/10 , C08G69/40 , C08G69/48 , C08L2203/02
摘要： [Problems] To provide a novel taxane derivative which can release the medicinal substance in a bioenzyme-independent manner, is expected to have an effective therapeutic efficacy, and has a water-solubility.[Means for Solving Problems] Disclosed is a polymer conjugate of a taxane, which comprises a polymer having a polyethylene glycol moiety and two or more succinic acid monoamide moieties and a taxane, wherein a carboxylate group in the polymer and an alcoholic hydroxyl group in the taxane are bound to each other via an ester bonding.
摘要翻译： [问题]为了提供能够以不依赖生物酶的方式释放药物的新型紫杉烷衍生物，预期具有有效的治疗功效，并且具有水溶性。 解决问题的手段公开了紫杉烷的聚合物缀合物，其包含具有聚乙二醇部分和两个或多个琥珀酸单酰胺部分的聚合物和紫杉烷，其中聚合物中的羧酸酯基团和 紫杉烷通过酯键相互结合。
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公开(公告)号：US07717027B2
公开(公告)日：2010-05-18
申请号：US11624607
申请日：2007-01-18
申请人： Takeshi Sato , Takashi Nagasawa , Takeshi Onda
发明人： Takeshi Sato , Takashi Nagasawa , Takeshi Onda
IPC分类号： A47J31/36
CPC分类号： A47J31/3638 , A47J31/36 , A47J31/3609 , A47J31/3614 , A47J31/3619 , A47J31/3633
摘要： The invention provides a beverage extractor permitting extraction of a beverage of high quality irrespective of its type. The extractor is provided with a first extraction channel for letting the beverage extracted in a cylinder flow into the extraction pipe via beverage outlet holes of a second piston having a prescribed first bore and a second extraction channel via a communication hole having a prescribed second bore, which is smaller in bore than the outlet holes, for letting the beverage extracted in the cylinder flow into the extraction pipe, and the first and second extraction channels are switched over between each other by the movement of the second piston. This makes it possible to select an extraction channel suitable for the type of beverage, whether regular coffee or espresso coffee, and accordingly to extract a beverage of high quality irrespective of the type of beverage.
摘要翻译： 本发明提供一种饮料提取器，其允许提取高品质的饮料，而不管其类型如何。 提取器设置有第一提取通道，用于通过具有规定的第二孔的连通孔，将经气瓶抽取的饮料通过具有规定的第一孔的第二活塞和第二提取通道的饮料出口孔流入提取管， 其中孔径比出口孔小，用于使在汽缸中提取的饮料流入萃取管，并且第一和第二提取通道通过第二活塞的运动而在彼此之间切换。 这使得可以选择适合于饮料类型的提取通道，无论是常规咖啡还是咖啡浓缩咖啡，并且因此提取高质量的饮料，而与饮料类型无关。
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公开(公告)号：US20080290108A1
公开(公告)日：2008-11-27
申请号：US12124811
申请日：2008-05-21
IPC分类号： B65H1/28
CPC分类号： G07F11/42 , G07F11/16 , G07F11/165 , G07F11/30
摘要： The present invention provides a commodity carrying out device that can reliably carry out even a commodity with a vertically long shape to a predetermined commodity carrying out position without producing a carrying-out failure. That is, when a bucket unit that receives a commodity is moved in a width direction towards a predetermined commodity carrying out position, the commodity is retained in an inclined state. It is thus possible to retain the commodity in a stable posture in the bucket unit that moves towards the predetermined commodity carrying out position, and even when carrying out a commodity that has a vertically long shape, the commodity can be reliably carried out to the commodity outlet portion without producing a carrying-out failure.
摘要翻译： 本发明提供一种商品执行装置，其可以将具有垂直长形状的商品可靠地执行到预定商品执行位置而不产生执行故障。 也就是说，当接收商品的铲斗单元沿宽度方向朝向预定商品执行位置移动时，商品保持在倾斜状态。 因此，可以将商品保持在朝向预定商品执行位置移动的铲斗单元中的稳定姿势，并且即使在执行具有竖直长形状的商品时，商品也可以可靠地进行到商品 出口部分，而不产生执行故障。
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