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    1-Azaxanthone derivatives
    1.
    发明授权
    1-Azaxanthone derivatives 失效
    1-氮杂酮衍生物

    公开(公告)号：US4299963A

    公开(公告)日：1981-11-10

    申请号：US177580

    申请日：1980-08-13

    申请人： Akira Nohara ,  Hirosada Sugihara ,  Kiyoshi Ukawa

    发明人： Akira Nohara ,  Hirosada Sugihara ,  Kiyoshi Ukawa

    IPC分类号： C07D311/58 ,  C07D491/04 ,  C07D491/052

    CPC分类号： C07D491/04 ,  C07D311/58

    摘要： The present invention relates to novel 1-azaxanthone-3-carboxylic acid and its derivatives usable for effective medicines for the treatment of allergic diseases, which are shown by the following formula (I) ##STR1## wherein R.sub.1 is hydrogen, alkyl, phenyl, carboxyl, hydroxyl, alkoxy or amino group which may be unsubstituted or substituted by one alkyl, m is 0, 1 or 2 and R.sub.2 is alkyl, alkoxy, halogen, nitro, hydroxy, carboxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms or amino group which may be unsubstituted or substituted by at least one alkyl, and their physiologically acceptable salts.

    摘要翻译： 本发明涉及可用于治疗过敏性疾病的有效药物的新型1-氮杂酮-3-羧酸及其衍生物，其由下式（I）表示：其中R 1为氢，烷基 ，可以是未取代的或被一个烷基取代的苯基，羧基，羟基，烷氧基或氨基，m是0,1或2，R2是烷基，烷氧基，卤素，硝基，羟基，羧基，丁二烯基（-CH = CH- CH = CH-），其形成具有任何相邻碳原子的苯环或可被未取代或被至少一个烷基取代的氨基，及其生理上可接受的盐。

    1-Azaxanthone-3-carboxylic acids
    2.
    发明授权
    1-Azaxanthone-3-carboxylic acids 失效
    1-AZAXANTHONE-3-CARBOXYLIC ACIDS

    公开(公告)号：US4143042A

    公开(公告)日：1979-03-06

    申请号：US881237

    申请日：1978-02-27

    申请人： Akira Nohara ,  Hirosada Sugihara ,  Kiyoshi Ukawa

    发明人： Akira Nohara ,  Hirosada Sugihara ,  Kiyoshi Ukawa

    IPC分类号： C07D311/58 ,  C07D491/04 ,  C07D491/052

    CPC分类号： C07D491/04 ,  C07D311/58

    摘要： The present invention relates to novel 1-azaxanthone-3-carboxylic acid and its derivatives usable for effective medicines for the treatment of allergic diseases, which are shown by the following formula (I) ##STR1## wherein R.sub.1 is hydrogen, alkyl, phenyl, carboxyl, hydroxyl, alkoxy or amino group which may be unsubstituted or substituted by one alkyl, m is 0, 1 or 2 and R.sub.2 is alkyl, alkoxy, halogen, nitro, hydroxy, carboxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms or amino group which may be unsubstituted or substituted by at least one alkyl, and their physiologically acceptable salts.

    1-Azaxanthone derivatives
    3.
    发明授权
    1-Azaxanthone derivatives 失效
    1-氮杂酮衍生物

    公开(公告)号：US4255576A

    公开(公告)日：1981-03-10

    申请号：US970105

    申请日：1978-12-18

    申请人： Akira Nohara ,  Hirosada Sugihara ,  Kiyoshi Ukawa

    发明人： Akira Nohara ,  Hirosada Sugihara ,  Kiyoshi Ukawa

    IPC分类号： C07D311/58 ,  C07D491/04 ,  C07D491/052

    CPC分类号： C07D491/04 ,  C07D311/58

    摘要： The present invention relates to novel 1-azaxanthone derivatives, which are shown by the following formula: ##STR1## wherein m is 1 or 2R'.sub.1 is hydrogen, C.sub.1-6 alkyl, phenyl, C.sub.1-6 alkoxycarbonyl, hydroxy, C.sub.1-4 alkoxy, amino or C.sub.1-3 alkylamino;each of R.sub.2 is independently C.sub.1-6 alkyl, C.sub.1-4 alkoxy, halogen, nitro, hydroxy, carboxy, amino, C.sub.1-3 alkylamino or di(C.sub.1-3 alkyl) amino; orwhen m is 2, the two R.sub.2 groups may be independently as defined above or may form together with adjacent rings carbon atoms the butadienylene group;R.sub.3 is cyano, C.sub.1-6 alkoxycarbonyl, carboxamide, N-C.sub.1-3 alkylcarboxamide or N,N-di(C.sub.1-3 alkyl) carboxamide.The novel derivatives are useful as intermediates for 1-azaxanthone-3-carboxylic acid derivatives having effective antiallergic and bronchodilating activities.

    摘要翻译： 本发明涉及由下式表示的新颖的1-氮杂酮衍生物：其中m为1或2，R'1为氢，C1-6烷基，苯基，C1-6烷氧基羰基，羟基，C1- 4个烷氧基，氨基或C 1-3烷基氨基; 每个R 2独立地是C 1-6烷基，C 1-4烷氧基，卤素，硝基，羟基，羧基，氨基，C 1-3烷基氨基或二（C 1-3烷基）氨基; 或当m为2时，两个R 2基团可以独立地如上定义，或者可以与相邻的环碳原子一起形成亚丁二烯基; R 3是氰基，C 1-6烷氧基羰基，甲酰胺，N-C 1-3烷基羧酰胺或N，N-二（C 1-3烷基）甲酰胺。 该新型衍生物可用作具有有效抗过敏和支气管扩张活性的1-氮杂酮-3-羧酸衍生物的中间体。

    3-(Trisubstituted benzoyl)-propionic acid
    5.
    发明授权
    3-(Trisubstituted benzoyl)-propionic acid 失效
    3-（三取代苯甲酰基） - 丙酸

    公开(公告)号：US3943169A

    公开(公告)日：1976-03-09

    申请号：US288348

    申请日：1972-09-12

    申请人： Tadakazu Murata ,  Akira Nohara ,  Hirosada Sugihara ,  Yasushi Sanno

    发明人： Tadakazu Murata ,  Akira Nohara ,  Hirosada Sugihara ,  Yasushi Sanno

    IPC分类号： A61K31/19 ,  C07C45/46 ,  C07C49/84 ,  C07C59/185 ,  C07C59/84 ,  C07C59/90 ,  C07D317/60 ,  C07D317/64 ,  C07C65/00 ,  C07C65/22

    CPC分类号： A61K31/19 ,  C07C323/00 ,  C07C45/46 ,  C07C49/84 ,  C07C59/90 ,  C07D317/60 ,  C07D317/64

    摘要： The present invention relates to a compound of the formula: ##SPC1##Wherein R.sub.1 is an alkyl group of 1 to 4 carbons, an alkoxy group of 1 to 4 carbons or hydroxyl, and R.sub.2 and R.sub.3 are either the same or different and may be an alkyl group of 1 to 4 carbons, an alkoxy group of 1 to 4 carbons, hydroxyl, halogen or an alkylthio group of 1 to 4 carbons, or they are, connecting with each other, an alkylenedioxy group of 1 to 3 carbons, with the proviso that when R.sub.1 is an alkoxy group, at least one of R.sub.2 and R.sub.3 is an alkoxy group or an alkylthio group, or R.sub.2 and R.sub.3 are, connecting with each other, an alkylenedioxy group; when R.sub.1 is an alkyl group or hydroxyl, R.sub.2 and R.sub.3 are the same or different and may be an alkoxy group, an alkylthio group or, connecting with each other, an alkylene dioxy group; when R.sub.2 and R.sub.3 are methoxy, R.sub.1 is an alkyl group of 2 or 3 carbons, an alkoxy group of 2 to 4 carbons or hydroxyl, and when R.sub.2 is methyl and R.sub.3 is methoxy, R.sub.1 is an alkoxy group of 2 to 4 carbons or its pharmaceutically acceptable salts. The present invention also provides for a method of preparing the aforementioned compounds. The present compounds are characterized by exhibiting strong spasmolytic or relaxing action on the gall bladder, the common biliary duct, as well as exhibiting strong choleric activity and low toxicity.

    摘要翻译： 本发明涉及下式的化合物：

    1-Azaxanthone-3-carboxylic acids and their production
    7.
    发明授权
    1-Azaxanthone-3-carboxylic acids and their production 失效
    1-氮杂酮-3-羧酸及其制备

    公开(公告)号：US4302463A

    公开(公告)日：1981-11-24

    申请号：US185954

    申请日：1980-09-10

    申请人： Toshihiro Ishiguro ,  Kiyoshi Ukawa ,  Akira Nohara

    发明人： Toshihiro Ishiguro ,  Kiyoshi Ukawa ,  Akira Nohara

    IPC分类号： A61K31/435 ,  A61P37/08 ,  C07D491/04 ,  C07D491/052 ,  C07F9/6561 ,  A61K31/44

    CPC分类号： C07D491/04 ,  C07F9/6561

    摘要： Novel 1-azaxanthone-3-carboxylic acid derivatives, which are shown by the following formula (I) ##STR1## wherein R is hydrogen, alkyl, alkoxy or halogen; R.sub.1 and R.sub.2 are the same or different and each is hydrogen, alkyl or alkenyl; and m is 1 or 2; and their physiologically acceptable salts, are usable as effective medicines for preventing and/or treating allergic diseases. The compound of the formula (I) can be produced by reacting a compound of the formula: ##STR2## wherein R and m have the same meaning as defined above; R.sub.3 is carboxyl or group which is convertible into carboxyl through hydrolysis; X is alkyl phosphate radical or halogen, with a compound of the formula: ##STR3## wherein R.sub.1 and R.sub.2 have the same meaning as defined above, or its salt, and conducting hydrolysis, if necessary.

    摘要翻译： 新的1-氮杂酮-3-羧酸衍生物，其由下式（I）表示：其中R是氢，烷基，烷氧基或卤素; R1和R2相同或不同，各自为氢，烷基或烯基; m为1或2; 及其生理上可接受的盐可用作预防和/或治疗过敏性疾病的有效药物。 式（I）的化合物可以通过使下式化合物：其中R和m具有与上述定义相同的含义： R3是羧基或通过水解可转化为羧基的基团; X是烷基磷酸根或卤素，具有下式的化合物：其中R 1和R 2具有与上述相同的含义或其盐，并且如果需要进行水解。

    3-(Tetrazol-5-yl)-1-azaxanthones
    8.
    发明授权
    3-(Tetrazol-5-yl)-1-azaxanthones 失效
    3-（四唑-5-基）-1-哒嗪酮

    公开(公告)号：US4267332A

    公开(公告)日：1981-05-12

    申请号：US942925

    申请日：1978-09-18

    申请人： Akira Nohara ,  Toshihiro Ishiguro ,  Kiyoshi Ukawa

    发明人： Akira Nohara ,  Toshihiro Ishiguro ,  Kiyoshi Ukawa

    IPC分类号： A61K31/435 ,  A61K31/436 ,  A61P37/08 ,  C07D311/22 ,  C07D403/04 ,  C07D491/04 ,  C07D491/052 ,  C07D273/01 ,  A61K31/395

    CPC分类号： C07D491/04 ,  C07D311/22

    摘要： Novel 3-(tetrazol-5-yl)-1-azaxanthone and its derivatives, which are shown by the following formula ##STR1## wherein R.sub.1 is hydrogen, amino or hydroxyl; R.sub.2 is alkyl, alkoxy, halogen, nitro, carboxyl, hydroxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms or amino group which may be unsubstituted or substituted by at least one alkyl; and m is 0, 1 or 2; and their physiologically acceptable salts, are usable as effective medicines for preventing and/or treating allergic diseases.

    摘要翻译： 新的3-（四唑-5-基）-1-氮杂呫吨酮及其衍生物，其由下式表示：其中R1是氢，氨基或羟基; R2是烷基，烷氧基，卤素，硝基，羧基，羟基，亚丁二烯基（-CH = CH-CH = CH-），其形成具有任何相邻碳原子的苯环或可以是未取代的或被至少一个烷基取代的氨基 ; m为0,1或2; 及其生理上可接受的盐可用作预防和/或治疗过敏性疾病的有效药物。

    Noise signal prediction system
    9.
    发明授权
    Noise signal prediction system 失效
    噪声信号预测系统

    公开(公告)号：US5490231A

    公开(公告)日：1996-02-06

    申请号：US117538

    申请日：1993-09-07

    申请人： Joji Kane ,  Akira Nohara

    发明人： Joji Kane ,  Akira Nohara

    IPC分类号： G10L21/0208 ,  G10L25/18 ,  G10L9/00

    CPC分类号： G10L21/0208 ,  G10L25/18

    摘要： A noise signal prediction system includes a signal detector for receiving a mixed signal having a voice signal and a background noise signal and for detecting the presence and absence of the voice signal contained in the mixed signal. A noise level detector is provided for detecting an actual noise level at each sampling cycle during the absence of the voice signal. A storing circuit stores the noise levels for a predetermined number of past sampling cycles. A predicting circuit predicts a noise level of a next sampling cycle based on the stored noise levels in the storing circuit. The storing circuit receiving and stores the actual noise levels during the absence of the voice signal, but stores the predicted noise levels during the presence of the voice signal.

    摘要翻译： 噪声信号预测系统包括：信号检测器，用于接收具有语音信号和背景噪声信号的混合信号，并用于检测混合信号中包含的语音信号的存在与否。 提供噪声电平检测器，用于在没有语音信号的情况下检测每个采样周期的实际噪声电平。 存储电路存储预定数量的过去采样周期的噪声电平。 预测电路基于存储电路中存储的噪声电平预测下一采样周期的噪声电平。 存储电路在没有语音信号的过程中接收并存储实际的噪声电平，但是在语音信号存在期间存储预测的噪声电平。

    Noise suppression apparatus
    10.
    发明授权
    Noise suppression apparatus 失效
    噪声抑制装置

    公开(公告)号：US5428832A

    公开(公告)日：1995-06-27

    申请号：US29247

    申请日：1993-03-10

    申请人： Akira Nohara ,  Joji Kane

    发明人： Akira Nohara ,  Joji Kane

    IPC分类号： G10L15/20 ,  G10L11/02 ,  G10L15/04 ,  G10L21/02 ,  H03G9/02 ,  H04B1/10

    CPC分类号： H03G9/005 ,  H03G9/02 ,  H04B1/1027

    摘要： A noise suppression apparatus comprising a tuner 1 which selectively receiving a radio wave signal to be received and transforming it into an electric signal, a field information detector 2 which detects electric field information of the radio wave signal received by the tuner 1, a noise data generator 6 which generates a noise pattern on the basis of the electric field information .detected by the field information detector 2, a noise canceler 4 which removes an noise component from the signal outputted from the tuner 1 on the basis of the noise pattern generated by the noise data generator 6, and an amplifier 7 which outputs a noiseless signal outputted from the noise canceler 4.

    摘要翻译： 一种噪声抑制装置，包括选择性地接收要接收的无线电波信号并将其转换为电信号的调谐器1，检测由调谐器1接收的无线电波信号的电场信息的场信息检测器2，噪声数据 发生器6，其基于由场信息检测器2检测的电场信息产生噪声模式;噪声消除器4，其基于由调谐器1输出的信号，根据由调谐器1产生的噪声模式消除噪声分量 噪声数据发生器6和输出从噪声消除器4输出的无噪声信号的放大器7。