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    Treating biological tissues to mitigate post-implantation calcification
    2.
    发明授权
    Treating biological tissues to mitigate post-implantation calcification 有权
    治疗生物组织以减轻植入后钙化

    公开(公告)号：US08236241B2

    公开(公告)日：2012-08-07

    申请号：US11744614

    申请日：2007-05-04

    申请人： Alain F. Carpentier ,  Sophie Carpentier ,  Crystal M. Cunanan ,  Lillian J. Quintero ,  Michael N. Helmus ,  Christine Loshbaugh ,  H. Chris Sarner

    发明人： Alain F. Carpentier ,  Sophie Carpentier ,  Crystal M. Cunanan ,  Lillian J. Quintero ,  Michael N. Helmus ,  Christine Loshbaugh ,  H. Chris Sarner

    IPC分类号： A61L2/00 ,  A61F2/02

    CPC分类号： A61L27/3691 ,  A61L2/0088 ,  A61L27/3604 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/3687 ,  A61L33/12 ,  A61L2400/02 ,  A61L2430/40 ,  Y10S623/901 ,  Y10S623/915 ,  Y10S623/917 ,  Y10S623/92

    摘要： A method of treating a biological tissue including crosslinking with glutaraldehyde; immersing the biological tissue in a first solution containing glutaraldehyde and heat in the first solution to a temperature of about 50° C. for a first period of time; immersing the biological tissue in a second solution containing a mixture of a crosslinking agent, a denaturing agent and a surfactant; and immersing the biological tissue in a sterilizing solution containing glutaraldehyde and heating the sterilizing solution to a temperature of 37.5±2.5° C. for a sterilizing period of time. The method may include a terminal sterilization step in a method for fixation of biological tissues, and bioprosthetic devices may be prepared by such fixation method. The fixation method may include the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to the terminal sterilization method.

    摘要翻译： 一种治疗生物组织的方法，包括用戊二醛交联; 将生物组织浸入含有戊二醛的第一溶液中并在第一溶液中加热至约50℃的温度持续第一时间; 将生物组织浸渍在含有交联剂，变性剂和表面活性剂的混合物的第二溶液中; 将生物体组织浸渍在含有戊二醛的杀菌溶液中并将灭菌液加热至37.5±2.5℃的温度进行杀菌的时间。 该方法可以包括用于固定生物组织的方法中的终端灭菌步骤，并且生物假体装置可以通过这种固定方法制备。 固定方法可以包括以下步骤：A）固定组织，B）用i）变性剂，ii）表面活性剂和iii）交联剂的混合物处理组织，C）制造或形成生物假体（例如，形成 组织并附着任何非生物组分）和D）使生物假体进行终末灭菌方法。