专利检索 ap:("Alan D. Snow" OR "Beth P. Nguyen" OR "Gerardo M. Castillo" OR "Virginia J. Sanders" OR "Thomas P. Lake" OR "Lesley Larsen" OR "Rex T. Weavers" OR "Stephen D. Lorimer" OR "David S. Larsen" OR "David L. Coffen" OR "Chrlotte Coffen") AND inv:"Stephen D. Lorimer" 第 1 页

1.

发明申请
COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE 失效
标题翻译：用于治疗阿尔茨海默病，类型2糖尿病和帕金森病的淀粉样变性和合并症的化合物，组合物和方法

公开(公告)号：US20090069432A1

公开(公告)日：2009-03-12

申请号：US12264858

申请日：2008-11-04

申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Chrlotte Coffen

发明人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Chrlotte Coffen

IPC分类号： A61K31/167 , C07C233/75

CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08

摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是Aβ淀粉样变性中的用途，例如在阿尔茨海默病，IAPP淀粉样变性在2型糖尿病中观察到，以及突触核蛋白病，例如在帕金森病中观察到的，以及用于这种治疗的药物的制造。

2.

发明授权
Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease 失效
标题翻译：用于治疗淀粉样蛋白病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法

公开(公告)号：US07763747B2

公开(公告)日：2010-07-27

申请号：US12264858

申请日：2008-11-04

申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Charlotte Coffen, legal representative

发明人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen

IPC分类号： C07C69/035 , C07C69/21 , A61K31/222 , A61K31/225

CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08

摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是A＆诸如在阿尔茨海默病中观察到的淀粉样变性，诸如在2型糖尿病中观察到的IAPP淀粉样变性和诸如在帕金森病中观察到的突触核蛋白病，以及用于这种治疗的药物的制造。

3.

发明授权
Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis 有权
标题翻译：用于治疗淀粉样变性疾病如全身性AA淀粉样变性的化合物，组合物和方法

公开(公告)号：US07601876B2

公开(公告)日：2009-10-13

申请号：US11714894

申请日：2007-03-05

申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Charlotte Coffen, legal representative

发明人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen

IPC分类号： C07C33/00 , C07C49/00 , C07C209/00 , C07C211/00 , C07C233/00 , C07C239/00 , C07C275/00 , A61K31/00

CPC分类号： C07C39/15 , C07C39/16 , C07C39/17 , C07C69/017 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08

摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是Aβ淀粉样变性中的用途，例如在阿尔茨海默病，IAPP淀粉样变性在2型糖尿病中观察到，AA / SAA淀粉样变性，例如在全身性AA淀粉样变性和突触核蛋白病中观察到的，例如在帕金森病中观察到的，以及制备用于这种治疗的药物。