公开(公告)号：US5724987A

公开(公告)日：1998-03-10

申请号：US504653

申请日：1995-07-20

申请人： Alan Gevins ,  Harrison Leong ,  Isabel Sam-Vargas ,  Michael Smith

发明人： Alan Gevins ,  Harrison Leong ,  Isabel Sam-Vargas ,  Michael Smith

IPC分类号： A61B5/0484 ,  A61B5/16 ,  A61B5/0476

CPC分类号： A61B5/16 ,  A61B5/0484 ,  A61B5/7264

摘要： A computer-aided training system uses electroencephalograms (EEGs) recorded from the trainee's scalp to alter the training protocol being presented by the computer, for example to present a new task to the trainee when he or she has mastered and automatized the current task. The index of the trainee's skill mastery and automatization is determined by analysis of the EEG using mathematical classification functions which distinguish different levels of skill acquisition. The functions are computed by computer neural networks and consist of a combination of EEG and other physiological variables which specifically characterize a trainee's level of focused attention and neurocognitive workload and his or her neurocognitive strategy. The functions are derived either for a group of trainees, or each trainee individually, performing a battery of one or more standard training tasks while wearing an EEG hat.

摘要翻译： 计算机辅助训练系统使用从受训者的头皮记录的脑电图（EEG）来改变计算机呈现的训练协议，例如当他或她已经掌握和自动化当前任务时，向受训者呈现新的任务。 受训者的技能掌握和自动化的指标是通过使用区分不同技能获取水平的数学分类函数对脑电图进行分析来确定的。 这些功能由计算机神经网络计算，并由EEG和其他生理变量的组合组成，它们特别表征受训者的集中注意力和神经认知工作量以及他或她的神经认知策略。 这些功能是针对一组学员或每个学员单独导出的，在佩戴EEG帽子的同时执行一个或多个标准训练任务的电池。

公开(公告)号：US06947790B2

公开(公告)日：2005-09-20

申请号：US10121606

申请日：2002-04-15

申请人： Alan Gevins ,  Michael Smith

发明人： Alan Gevins ,  Michael Smith

IPC分类号： A61B5/0484 ,  A61B5/16 ,  A61B5/04 ,  A61B5/05

CPC分类号： A61B5/411 ,  A61B5/0484 ,  A61B5/16 ,  A61B5/4076 ,  A61B5/7264

摘要： An efficient, objective testing method and system for evaluating changes in mental function is described. The method and system are based on measuring an individual's behavioral responses and brain function during a brief cognitive test battery and passive control conditions. The method and system is designed to assess an individual's fundamental cognitive functions, and whether those functions have been significantly affected by a variety of factors such as progressive disease processes, medication, stress, fatigue, training, or the passage of time. The method and system can be used to determine whether drugs being evaluated to treat diseases or conditions affecting cognitive brain function have a significant positive effect on delaying or improving the symptoms of such a disease or condition, especially during clinical trials for drug approval and subsequent marketing. The method and system may also be employed as part of the successful diagnosis or ongoing treatment of neurological diseases or conditions that directly or indirectly affect human neurocognitive performance. The method and system may also be used to determine transitory changes in overall cognitive function due to emotional stress or fatigue, and more long lasting changes in overall cognitive function following training and educational programs.

摘要翻译： 描述了一种用于评估心理功能变化的有效，客观的测试方法和系统。 该方法和系统基于在简短的认知测试电池和被动控制条件期间测量个体的行为反应和脑功能。 该方法和系统旨在评估个体的基本认知功能，以及这些功能是否受到渐进疾病过程，药物治疗，压力，疲劳，训练或时间流逝等多种因素的严重影响。 该方法和系统可用于确定正在评估的药物是否用于治疗影响认知性脑功能的疾病或病症对延迟或改善这种疾病或病症的症状具有显着的积极影响，特别是在药物批准和随后营销的临床试验期间 。 该方法和系统也可用作成功诊断或持续治疗直接或间接影响人神经认知表现的神经疾病或病症的一部分。 该方法和系统也可用于确定由于情绪压力或疲劳引起的整体认知功能的暂时性变化，以及训练和教育计划后整体认知功能的持久变化。

公开(公告)号：US07551952B2

公开(公告)日：2009-06-23

申请号：US11259971

申请日：2005-10-26

申请人： Alan Gevins ,  Robert Howard ,  Art Sandoval

发明人： Alan Gevins ,  Robert Howard ,  Art Sandoval

IPC分类号： A61B5/04

CPC分类号： A61B5/0478 ,  A61B5/6814

摘要： An improved electrode headset is provided for the acquisition of electroencephalographic (EEG) brain signals detected at the scalp of a human subject. The headset includes an elastic fabric cap having a chinstrap, which cap is fitted closely to the scalp. The cap has openings at those selected locations on the scalp to which removable and disposable electrodes are to be removably connected to the scalp. A positioning unit, of a generally flat and flexible plastic material, is attachable to the cap by corresponding hook-and-loop fasteners on the outer surface of the cap and the inner surface of the positioning unit. The positioning unit has a base portion and two opposite leg portions, each with slits. Flat beams are adjustably connected through the slits to the leg portions and base portion. Each beam carries a screw member which adjustably applies pressure to electrode holders and a flexible electrode extractor strap to which the electrode holder is attached. Each electrode holder is snap fastened to an electrode positioned within a cap opening.

摘要翻译： 提供了一种改进的电极耳机，用于获取在人类受试者头皮上检测到的脑电图（EEG）脑信号。 头戴式耳机包括具有下颏的弹性织物盖，该帽与头皮紧密地配合。 帽子在头皮上的那些选定位置处具有开口，可去除和一次性电极可移除地连接到头皮。 大体平坦且柔软的塑料材料的定位单元可通过盖的外表面和定位单元的内表面上的相应的钩环紧固件附接到盖上。 定位单元具有基部和两个相对的腿部，每个具有狭缝。 扁平梁通过狭缝可调节地连接到腿部和基部。 每个梁承载可调整地对电极保持器施加压力的螺钉构件和附接有电极座的柔性电极提取器带。 每个电极保持器卡扣固定到位于盖开口内的电极。

公开(公告)号：US20080167571A1

公开(公告)日：2008-07-10

申请号：US11957156

申请日：2007-12-14

申请人： Alan Gevins

发明人： Alan Gevins

IPC分类号： A61B5/0476

CPC分类号： A61B5/0484 ,  A61B5/04842 ,  A61B5/04845 ,  A61B5/4094 ,  A61N1/08 ,  A61N1/36025

摘要： Disclosed are methods and data on determining response to a drug or other therapy prior to administration by obtaining a direct neurocognitive brain function measurement; obtaining an indirect neurocognitive brain function measurement; and, assessing the direct neurocognitive brain function measurement and the indirect neurocognitive brain function measurement collectively to obtain a response determination preferably the predictive value of the collective assessment is greater than a predictive value obtained from the separate predictive values for the direct and indirect measurements. Also disclosed are methods of determining dosage of a drug comprising administering a drug; comprising obtaining a direct neurocognitive brain function measurement; obtaining an indirect neurocognitive brain function measurement; and, assessing the direct neurocognitive brain function measurement and the indirect neurocognitive brain function measurement collectively to obtain a dosage, preferably the predictive value of the collective assessment is greater than a predictive value obtained from the separate predictive values for the direct and indirect measurements; optionally, additional cycles of obtaining and assessing indirect and direct measurements are performed.

摘要翻译： 公开了通过获得直接的神经认知性脑功能测量在给药前确定对药物或其他治疗的应答​​的方法和数据; 获得间接神经认知脑功能测量; 并且总体评估直接神经认知性脑功能测量和间接神经认知性脑功能测量以获得响应确定，优选地，集体评估的预测值大于从直接和间接测量的单独预测值获得的预测值。 还公开了确定药物剂量的方法，包括给予药物; 包括获得直接的神经认知脑功能测量; 获得间接神经认知脑功能测量; 并且总体评估直接神经认知脑功能测量和间接神经认知性脑功能测量以获得剂量，优选地，集体评估的预测值大于从直接和间接测量的单独预测值获得的预测值; 可选地，执行获得和评估间接和直接测量的附加循环。

公开(公告)号：US20070093706A1

公开(公告)日：2007-04-26

申请号：US11259971

申请日：2005-10-26

申请人： Alan Gevins ,  Robert Howard ,  Arthur Sandoval

发明人： Alan Gevins ,  Robert Howard ,  Arthur Sandoval

IPC分类号： A61B5/04

CPC分类号： A61B5/0478 ,  A61B5/6814

摘要： An improved electrode headset is provided for the acquisition of electroencephalographic (EEG) brain signals detected at the scalp of a human subject. The headset includes an elastic fabric cap having a chinstrap, which cap is fitted closely to the scalp. The cap has openings at those selected locations on the scalp to which removable and disposable electrodes are to be removably connected to the scalp. A positioning unit, of a generally flat and flexible plastic material, is attachable to the cap by corresponding hook-and-loop fasteners on the outer surface of the cap and the inner surface of the positioning unit. The positioning unit has a base portion and two opposite leg portions, each with slits. Flat beams are adjustably connected through the slits to the leg portions and base portion. Each beam carries a screw member which adjustably applies pressure to electrode holders and a flexible electrode extractor strap to which the electrode holder is attached. Each electrode holder is snap fastened to an electrode positioned within a cap opening.

摘要翻译： 提供了一种改进的电极耳机，用于获取在人类受试者头皮上检测到的脑电图（EEG）脑信号。 头戴式耳机包括具有下颏的弹性织物盖，该帽与头皮紧密地配合。 帽子在头皮上的那些选定位置处具有开口，可去除和一次性电极可移除地连接到头皮。 大体平坦且柔软的塑料材料的定位单元可通过盖的外表面和定位单元的内表面上的相应的钩环紧固件附接到盖上。 定位单元具有基部和两个相对的腿部，每个具有狭缝。 扁平梁通过狭缝可调节地连接到腿部和基部。 每个梁承载可调整地对电极保持器施加压力的螺钉构件和附接有电极座的柔性电极提取器带。 每个电极保持器卡扣固定到位于盖开口内的电极。