摘要:
The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structure X--Y--Leu--Phe--�Z!.sub.n --W wherein: X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent.
摘要翻译:本发明涉及通过向个体施用诊断或治疗有效量的可检测标记的,治疗性的或治疗上缀合的,可检测地标记的,治疗性的或治疗上缀合的,在个体中检测感染或炎症部位的方法和治疗这种感染或炎症的方法, 所述趋化肽基本上在感染或发炎部位积累,所述趋化肽具有通式X-Y-Leu-Phe- [Z] n -W其中:X为氨基保护基,Y为氨基酸残基,Z为 间隔序列,n为0或1,W为标记或连接取代基。
摘要:
The invention relates to a method of detecting an inflammation site in an individual by administering to the individual a diagnostically effective amount of detectably labeled immunoglobulin or fragment thereof, wherein the immunoglobulin substantially accumulates at the site when the site is inflamed.
摘要:
The invention relates to a method of detecting an Fc receptor-expressing tumor site in an individual by administering to the individual a diagnostically effective amount of detectably-labeled non-specific immunoglobulin or Fc or Fc' fragment thereof, wherein the immunoprotein substantially accumulates at the site when the site bears such a tumor. By using a therapeutically-labeled specific or non-specific immunoglobulin or Fc or Fc' fragment thereof, the tumor may be treated therapeutically.
摘要:
The invention relates to a method of detecting an Fc receptor-expressing tumor site in an individual by administering to the individual a diagnostically effective amount of detectably-labeled non-specific immunoglobulin or Fc or Fc' fragment thereof, wherein the immunoprotein substantially accumulates at the site when the site bears such a tumor. By using a therapeutically-labeled specific or non-specific immunoglobulin or Fc or Fc' fragment thereof, the tumor may be treated therapeutically.
摘要:
The invention relates to a method of detecting an inflammation site in an individual by administering to the individual a diagnostically effective amount of detectably labeled immunoglobulin or fragment thereof, wherein the immunoglobulin substantially accumulates at the site when the site is inflamed.
摘要:
The invention relates to a method of detecting an inflammation site in an individual by administering to the individual a diagnostically effective amount of detectably labeled immunoglobulin or fragment thereof, wherein the immunoglobulin substantially accumulates at the site when the site is inflamed.
摘要:
Methods, devices, and kits, for assessing luminal lesions are provided. The subject devices comprise an intraluminal detector capable of sensing radioactive or other labels. In the subject methods, a detectable marker is introduced to a body lumen, either into the lumen itself or systemically in patient circulation, and localizes at a lesion. The detector is introduced into the body lumen and the distribution of a localized marker detected in situ. The information is useful for a number of purposes including the identification of unstable plaque in patients suffering from atherosclerotic disease.
摘要:
An ambulatory ventricular function anaylzer system is provided. The ambulatory ventricular function analyzer system is carried by a garment worn by a cardiac patient and includes ECG electrodes, a main left ventricular probe detector, and a background lung probe detector for providing diagnostically useful information while the patient goes about the normal activities of daily life. An information processing sub-system including a microprocessor responds to the electrode signal and to the probe signals and provides composite data representative of the ECG activity, the background lung time-activity, the left ventricular time-activity, and an R-wave histogram averaged over multiple cardiac cycles. The averaged data is sequentially sotred over a long time interval on magnetic tape in plural categories representing premature ventricular contraction, postpremature ventricular contraction, and normal ventricular contraction for subsequent display on a computer-based graphics display for study by a cardiac specialist. The main left ventricular function probe detector includes an array of cadmium telluride crystals mounted in a Pb housing having a parallel hole Pb collimator. The detector is substantially insensitive to position changes that arise during ambulatory monitoring.