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公开(公告)号：US07888332B2
公开(公告)日：2011-02-15
申请号：US12175982
申请日：2008-07-18
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： A61K31/165 , A01K67/027 , A01K2227/105 , A01K2267/0306 , A61K31/195 , A61K31/47 , A61K31/7012 , C07D215/38 , Y02A50/471
摘要： The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions and pharmaceutical preparations of the invention may comprise one or more hydrazide-containing compounds, and may additionally comprise one or more pharmaceutically acceptable carriers, excipients and/or adjuvants. The methods of the invention comprise, in certain embodiments, administering to a patient suffering from a CFTR-mediated disease or condition, an efficacious amount of a hydrazide-containing compound. In other embodiments the invention provides methods of inhibiting CFTR that comprise contacting cells in a subject with an effective amount of a hydrazide-containing compound. In addition, the invention features a non-human animal model of CFTR-mediated disease which model is produced by administration of a hydrazide-containing compound to a non-human animal in an amount sufficient to inhibit CFTR.
摘要翻译： 本发明提供用于抑制囊性纤维化跨膜传导调节蛋白（CFTR）的组合物，药物制剂和方法，其可用于研究和治疗CFTR介导的疾病和病症。 本发明的组合物和药物制剂可以包含一种或多种含酰肼的化合物，并且还可以包含一种或多种药学上可接受的载体，赋形剂和/或佐剂。 在某些实施方案中，本发明的方法包括给予患有CFTR介导的疾病或病症的患者，有效量的含酰肼的化合物。 在其它实施方案中，本发明提供了抑制CFTR的方法，其包括使受试者中的细胞与有效量的含酰肼化合物接触。 此外，本发明的特征在于CFTR介导的疾病的非人动物模型，其通过以足以抑制CFTR的量向非人动物施用含酰肼的化合物来产生该模型。
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公开(公告)号：US07414037B2
公开(公告)日：2008-08-19
申请号：US11093749
申请日：2005-03-29
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： A61K31/165 , A01K67/027 , A01K2227/105 , A01K2267/0306 , A61K31/195 , A61K31/47 , A61K31/7012 , C07D215/38 , Y02A50/471
摘要： The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions and pharmaceutical preparations of the invention may comprise one or more hydrazide-containing compounds, and may additionally comprise one or more pharmaceutically acceptable carriers, excipients and/or adjuvants. The methods of the invention comprise, in certain embodiments, administering to a patient suffering from a CFTR-mediated disease or condition, an efficacious amount of a hydrazide-containing compound. In other embodiments the invention provides methods of inhibiting CFTR that comprise contacting cells in a subject with an effective amount of a hydrazide-containing compound. In addition, the invention features a non-human animal model of CFTR-mediated disease which model is produced by administration of a hydrazide-containing compound to a non-human animal in an amount sufficient to inhibit CFTR.
摘要翻译： 本发明提供用于抑制囊性纤维化跨膜传导调节蛋白（CFTR）的组合物，药物制剂和方法，其可用于研究和治疗CFTR介导的疾病和病症。 本发明的组合物和药物制剂可以包含一种或多种含酰肼的化合物，并且还可以包含一种或多种药学上可接受的载体，赋形剂和/或佐剂。 在某些实施方案中，本发明的方法包括给予患有CFTR介导的疾病或病症的患者，有效量的含酰肼的化合物。 在其它实施方案中，本发明提供了抑制CFTR的方法，其包括使受试者中的细胞与有效量的含酰肼化合物接触。 此外，本发明的特征在于CFTR介导的疾病的非人动物模型，其通过以足以抑制CFTR的量向非人动物施用含酰肼的化合物来产生该模型。
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公开(公告)号：US20110119775A1
公开(公告)日：2011-05-19
申请号：US13011626
申请日：2011-01-21
IPC分类号： A01K67/00 , C07C243/22 , A61K31/165 , C12N5/071 , A61P13/00 , A61P13/12
CPC分类号： A61K31/165 , A01K67/027 , A01K2227/105 , A01K2267/0306 , A61K31/195 , A61K31/47 , A61K31/7012 , C07D215/38 , Y02A50/471
摘要： The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions and pharmaceutical preparations of the invention may comprise one or more hydrazide-containing compounds, and may additionally comprise one or more pharmaceutically acceptable carriers, excipients and/or adjuvants. The methods of the invention comprise, in certain embodiments, administering to a patient suffering from a CFTR-mediated disease or condition, an efficacious amount of a hydrazide-containing compound. In other embodiments the invention provides methods of inhibiting CFTR that comprise contacting cells in a subject with an effective amount of a hydrazide-containing compound. In addition, the invention features a non-human animal model of CFTR-mediated disease which model is produced by administration of a hydrazide-containing compound to a non-human animal in an amount sufficient to inhibit CFTR.
摘要翻译： 本发明提供用于抑制囊性纤维化跨膜传导调节蛋白（CFTR）的组合物，药物制剂和方法，其可用于研究和治疗CFTR介导的疾病和病症。 本发明的组合物和药物制剂可以包含一种或多种含酰肼的化合物，并且还可以包含一种或多种药学上可接受的载体，赋形剂和/或佐剂。 在某些实施方案中，本发明的方法包括给予患有CFTR介导的疾病或病症的患者，有效量的含酰肼的化合物。 在其它实施方案中，本发明提供了抑制CFTR的方法，其包括使受试者中的细胞与有效量的含酰肼化合物接触。 此外，本发明的特征在于CFTR介导的疾病的非人动物模型，其通过以足以抑制CFTR的量向非人动物施用含酰肼的化合物来产生该模型。
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公开(公告)号：US20090048207A1
公开(公告)日：2009-02-19
申请号：US12175982
申请日：2008-07-18
IPC分类号： A61K31/7016 , A61K31/16 , C12N5/02 , A61K31/195 , A61K31/47
CPC分类号： A61K31/165 , A01K67/027 , A01K2227/105 , A01K2267/0306 , A61K31/195 , A61K31/47 , A61K31/7012 , C07D215/38 , Y02A50/471
摘要： The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions and pharmaceutical preparations of the invention may comprise one or more hydrazide-containing compounds, and may additionally comprise one or more pharmaceutically acceptable carriers, excipients and/or adjuvants. The methods of the invention comprise, in certain embodiments, administering to a patient suffering from a CFTR-mediated disease or condition, an efficacious amount of a hydrazide-containing compound. In other embodiments the invention provides methods of inhibiting CFTR that comprise contacting cells in a subject with an effective amount of a hydrazide-containing compound. In addition, the invention features a non-human animal model of CFTR-mediated disease which model is produced by administration of a hydrazide-containing compound to a non-human animal in an amount sufficient to inhibit CFTR.
摘要翻译： 本发明提供用于抑制囊性纤维化跨膜传导调节蛋白（CFTR）的组合物，药物制剂和方法，其可用于研究和治疗CFTR介导的疾病和病症。 本发明的组合物和药物制剂可以包含一种或多种含酰肼的化合物，并且还可以包含一种或多种药学上可接受的载体，赋形剂和/或佐剂。 在某些实施方案中，本发明的方法包括给予患有CFTR介导的疾病或病症的患者，有效量的含酰肼的化合物。 在其它实施方案中，本发明提供了抑制CFTR的方法，其包括使受试者中的细胞与有效量的含酰肼化合物接触。 此外，本发明的特征在于CFTR介导的疾病的非人动物模型，其通过以足以抑制CFTR的量向非人动物施用含酰肼的化合物来产生该模型。
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公开(公告)号：US20050239740A1
公开(公告)日：2005-10-27
申请号：US11093749
申请日：2005-03-29
IPC分类号： A61K31/165 , A61K31/195 , A61K31/47 , A61K31/7012
CPC分类号： A61K31/165 , A01K67/027 , A01K2227/105 , A01K2267/0306 , A61K31/195 , A61K31/47 , A61K31/7012 , C07D215/38 , Y02A50/471
摘要： The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions and pharmaceutical preparations of the invention may comprise one or more hydrazide-containing compounds, and may additionally comprise one or more pharmaceutically acceptable carriers, excipients and/or adjuvants. The methods of the invention comprise, in certain embodiments, administering to a patient suffering from a CFTR-mediated disease or condition, an efficacious amount of a hydrazide-containing compound. In other embodiments the invention provides methods of inhibiting CFTR that comprise contacting cells in a subject with an effective amount of a hydrazide-containing compound. In addition, the invention features a non-human animal model of CFTR-mediated disease which model is produced by administration of a hydrazide-containing compound to a non-human animal in an amount sufficient to inhibit CFTR.
摘要翻译： 本发明提供用于抑制囊性纤维化跨膜传导调节蛋白（CFTR）的组合物，药物制剂和方法，其可用于研究和治疗CFTR介导的疾病和病症。 本发明的组合物和药物制剂可以包含一种或多种含酰肼的化合物，并且还可以包含一种或多种药学上可接受的载体，赋形剂和/或佐剂。 在某些实施方案中，本发明的方法包括给予患有CFTR介导的疾病或病症的患者，有效量的含酰肼的化合物。 在其它实施方案中，本发明提供了抑制CFTR的方法，其包括使受试者中的细胞与有效量的含酰肼化合物接触。 此外，本发明的特征在于CFTR介导的疾病的非人动物模型，其通过以足以抑制CFTR的量向非人动物施用含酰肼的化合物来产生该模型。
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