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4 条记录 (耗时 0.017 秒)

    Hydrazide-containing CFTR inhibitor compounds and uses thereof
    1.
    发明申请
    Hydrazide-containing CFTR inhibitor compounds and uses thereof 有权
    含酰肼的CFTR抑制剂化合物及其用途

    公开(公告)号：US20050239740A1

    公开(公告)日：2005-10-27

    申请号：US11093749

    申请日：2005-03-29

    申请人： Alan Verkman ,  Nitin Sonawane ,  Chatchai Muanprasat

    发明人： Alan Verkman ,  Nitin Sonawane ,  Chatchai Muanprasat

    IPC分类号： A61K31/165 ,  A61K31/195 ,  A61K31/47 ,  A61K31/7012

    CPC分类号： A61K31/165 ,  A01K67/027 ,  A01K2227/105 ,  A01K2267/0306 ,  A61K31/195 ,  A61K31/47 ,  A61K31/7012 ,  C07D215/38 ,  Y02A50/471

    摘要： The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions and pharmaceutical preparations of the invention may comprise one or more hydrazide-containing compounds, and may additionally comprise one or more pharmaceutically acceptable carriers, excipients and/or adjuvants. The methods of the invention comprise, in certain embodiments, administering to a patient suffering from a CFTR-mediated disease or condition, an efficacious amount of a hydrazide-containing compound. In other embodiments the invention provides methods of inhibiting CFTR that comprise contacting cells in a subject with an effective amount of a hydrazide-containing compound. In addition, the invention features a non-human animal model of CFTR-mediated disease which model is produced by administration of a hydrazide-containing compound to a non-human animal in an amount sufficient to inhibit CFTR.

    摘要翻译： 本发明提供用于抑制囊性纤维化跨膜传导调节蛋白（CFTR）的组合物，药物制剂和方法，其可用于研究和治疗CFTR介导的疾病和病症。 本发明的组合物和药物制剂可以包含一种或多种含酰肼的化合物，并且还可以包含一种或多种药学上可接受的载体，赋形剂和/或佐剂。 在某些实施方案中，本发明的方法包括给予患有CFTR介导的疾病或病症的患者，有效量的含酰肼的化合物。 在其它实施方案中，本发明提供了抑制CFTR的方法，其包括使受试者中的细胞与有效量的含酰肼化合物接触。 此外，本发明的特征在于CFTR介导的疾病的非人动物模型，其通过以足以抑制CFTR的量向非人动物施用含酰肼的化合物来产生该模型。

    System and method for receiving broadcast multimedia on a mobile device
    2.
    发明申请
    System and method for receiving broadcast multimedia on a mobile device 有权
    用于在移动设备上接收广播多媒体的系统和方法

    公开(公告)号：US20090083803A1

    公开(公告)日：2009-03-26

    申请号：US12284948

    申请日：2008-09-26

    申请人： Osama Alshaykh ,  Chris Johnson ,  Steven K. Rossi ,  Nitin Sonawane ,  Jim Kosmach ,  Richard June

    发明人： Osama Alshaykh ,  Chris Johnson ,  Steven K. Rossi ,  Nitin Sonawane ,  Jim Kosmach ,  Richard June

    IPC分类号： H04N7/16

    CPC分类号： H04N21/4402 ,  H04N21/4126 ,  H04N21/43615 ,  H04N21/43637

    摘要： A system and a method receive broadcast multimedia on a mobile device. The system and the method may use a broadcast receiver accessory that may connect to a mobile device. The system and the method may have a bidirectional data connection between the broadcast receiver accessory and the mobile device. The broadcast receiver accessory may translate, reformat and/or repackage content into a form that may be viewed on the mobile device. The broadcast receiver accessory may have a tuner component, an application processor, an audio rendering element and/or memory.

    摘要翻译： 系统和方法在移动设备上接收广播多媒体。 系统和方法可以使用可以连接到移动设备的广播接收器附件。 该系统和方法可以在广播接收机附件和移动设备之间具有双向数据连接。 广播接收机附件可以将内容转换，重新格式化和/或重新包装成可以在移动设备上观看的形式。 广播接收机附件可以具有调谐器组件，应用处理器，音频呈现元件和/或存储器。