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公开(公告)号：US08101056B2
公开(公告)日：2012-01-24
申请号：US12567433
申请日：2009-09-25
IPC分类号： G01N27/403 , G01N27/327
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： A hollow electrochemical cell is provided. In one exemplary embodiment, a hollow electrochemical cell includes two sets of electrodes and an opening for admitting an analyte to the cell. At least one of the two sets of electrodes can be in fluid communication with the opening. Further, a first set of electrodes can include a working electrode spaced from a counter or counter/reference electrode by less than 500 μm one embodiment the working and counter or counter/reference electrodes are not co-planer. In another embodiment the working and counter or counter/reference electrodes are of substantially corresponding area. In yet another embodiment the working and counter or counter/reference electrodes are spaced from 100 to 200 μm apart. The first set of electrodes and the second set of electrodes can be spaced apart by greater than about 500 μm. Other embodiments of a hollow electrochemical cell are also provided, as are several embodiments of a glucose sensor.
摘要翻译： 提供了一种中空的电化学电池。 在一个示例性实施例中，中空电化学电池包括两组电极和用于允许分析物进入细胞的开口。 两组电极中的至少一个可以与开口流体连通。 此外，第一组电极可以包括与计数器或对准/参考电极间隔小于500μm的工作电极。 在一个实施例中，工作和计数器或计数器/参考电极不是共平面的。 在另一个实施例中，工作和计数器或计数器/参考电极具有基本对应的区域。 在又一个实施例中，工作和计数器或对准/参考电极间隔开100至200微米。 第一组电极和第二组电极可间隔开大于约500μm。 还提供了中空电化学电池的其它实施方案，葡萄糖传感器的几个实施方案也是如此。
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公开(公告)号：US20120145539A1
公开(公告)日：2012-06-14
申请号：US13357318
申请日：2012-01-24
IPC分类号： C25B9/00
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： Devices and methods are provided for determining the concentration of a reduced form of a redox species. For example, a device can include a working electrode and a counter electrode spaced by a predetermined distance so that reaction produces from the counter electrode arrive at the working electrode. An electric potential difference can be applied between the electrodes, and the potential of the working electrode can be selected such that the rate of electro-oxidation of the reduced form of the species is diffusion controlled. Current as a function of time can be determined, the magnitude of the steady state current can be estimated, and a value indicative of the diffusion coefficient and/or of the concentration of the reduced form of the species can be obtained from the change in current with time and the magnitude of the steady state current. Other embodiments of apparatuses, devices, and methods are also provided.
摘要翻译： 提供了用于确定还原形式的氧化还原物质的浓度的装置和方法。 例如，器件可以包括隔开预定距离的工作电极和对电极，使得从反电极产生的反应到达工作电极。 可以在电极之间施加电位差，并且可以选择工作电极的电位，使得物种的还原形式的电氧化速率被扩散控制。 可以确定作为时间的函数的电流，可以估计稳态电流的大小，并且可以从电流的变化获得指示物种的还原形式的扩散系数和/或浓度的值 随着时间和稳态电流的大小。 还提供了装置，装置和方法的其他实施例。
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公开(公告)号：US07604722B2
公开(公告)日：2009-10-20
申请号：US10624823
申请日：2003-07-22
IPC分类号： G01N27/327
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.
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公开(公告)号：US06413410B1
公开(公告)日：2002-07-02
申请号：US09618515
申请日：2000-07-18
IPC分类号： G01N2726
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.
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公开(公告)号：US08075760B2
公开(公告)日：2011-12-13
申请号：US12560773
申请日：2009-09-16
IPC分类号： G01N27/327
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： A method for determining the concentration of a reduced or oxidized form of a redox species is provided. In one exemplary embodiment, an electrochemical apparatus is provided in which the apparatus includes a hollow electrochemical cell for measuring a concentration of glucose in a blood sample, a current of the cell is measured, and a concentration of a redox mediator is determined, at least in part from, a measured current of the cell. The hollow electrochemical cell can include at least one non-metal working electrode, at least one counter electrode or counter/reference electrode, and a spacer interposed between the working electrode and the counter or counter/reference electrode. In one embodiment the working electrode and the counter or counter/reference electrode are not co-planer and are separated by a distance of from about 20 microns to about 200 microns. In another embodiment the working electrode and the counter or counter/reference electrode are not co-planer and the cell has an effective cell volume of less than 1.5 microliters.
摘要翻译： 提供了确定还原或氧化形式的氧化还原物质的浓度的方法。 在一个示例性实施例中，提供了一种电化学装置，其中所述装置包括用于测量血液样品中葡萄糖浓度的中空电化学电池，测量电池的电流，并且至少确定氧化还原介体的浓度 部分来自电池的测量电流。 中空电化学电池可以包括至少一个非金属工作电极，至少一个对电极或对置/参考电极，以及插入在工作电极和计数器或反/参比电极之间的间隔物。 在一个实施例中，工作电极和计数器或对位/参比电极不是共平面的并且分开约20微米至约200微米的距离。 在另一个实施例中，工作电极和计数器或对准/参比电极不是共平面的，并且电池具有小于1.5微升的有效电池容积。
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公开(公告)号：US20100084288A1
公开(公告)日：2010-04-08
申请号：US12560773
申请日：2009-09-16
IPC分类号： G01N27/26
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： A method for determining the concentration of a reduced or oxidized form of a redox species is provided. In one exemplary embodiment, an electrochemical apparatus is provided in which the apparatus includes a hollow electrochemical cell for measuring a concentration of glucose in a blood sample, a current of the cell is measured, and a concentration of a redox mediator is determined, at least in part from, a measured current of the cell. The hollow electrochemical cell can include at least one non-metal working electrode, at least one counter electrode or counter/reference electrode, and a spacer interposed between the working electrode and the counter or counter/reference electrode. In one embodiment the working electrode and the counter or counter/reference electrode are not co-planer and are separated by a distance of from about 20 microns to about 200 microns. In another embodiment the working electrode and the counter or counter/reference electrode are not co-planer and the cell has an effective cell volume of less than 1.5 microliters.
摘要翻译： 提供了确定还原或氧化形式的氧化还原物质的浓度的方法。 在一个示例性实施例中，提供了一种电化学装置，其中所述装置包括用于测量血液样品中葡萄糖浓度的中空电化学电池，测量电池的电流，并且至少确定氧化还原介体的浓度 部分来自电池的测量电流。 中空电化学电池可以包括至少一个非金属工作电极，至少一个对电极或对置/参考电极，以及插入在工作电极和计数器或反/参比电极之间的间隔物。 在一个实施例中，工作电极和计数器或对位/参比电极不是共平面的并且分开约20微米至约200微米的距离。 在另一个实施例中，工作电极和计数器或对准/参比电极不是共平面的，并且电池具有小于1.5微升的有效电池容积。
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公开(公告)号：US06960289B2
公开(公告)日：2005-11-01
申请号：US10035924
申请日：2001-12-21
IPC分类号： C12Q1/00 , G01N27/327 , G01N27/49
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.
摘要翻译： 本发明涉及一种生物传感器，更具体地说，涉及用于确定载体中分析物浓度的电化学生物传感器。 本发明对于确定血液中葡萄糖的浓度特别有用，并且在此参考该用途进行了描述，但是应当理解，本发明可应用于其它分析测定。
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公开(公告)号：US5980709A
公开(公告)日：1999-11-09
申请号：US973086
申请日：1997-10-10
IPC分类号： G01N27/28 , B01D61/38 , B01D65/00 , B01D67/00 , B01D69/00 , C25B9/10 , G01N27/30 , G01N27/40 , G01N27/403 , G01N27/26 , C25B11/00
CPC分类号： B01D67/0086 , G01N27/30
摘要： The present invention relates to a method for defining an area (4) of a layer on a porous substrate comprising compressing a volume of the substrate to produce a compressed region (8) which defines, or which in combination with an edge (7) of the substrate or of the layer defines, a boundary of the area and which substantially prevents the transport of material through or across its surface. The present invention also relates to an electrochemical sensing device comprising: a porous substrate; and an electrode (1) on one side of the substrate; wherein a region of the substrate is compressed to an extent which forms a barrier to migration of electrolyte within the substrate, the compressedregion defining, or in combination with an edge of the substrate or the electrode defining, a zone on the electrode of predetermined area.
摘要翻译： PCT No.PCT / AU96 / 00210 Sec。 371日期：1997年10月10日 102（e）1997年10月10日PCT PCT 1996年4月11日PCT公布。 公开号WO96 / 32635 PCT 日期：1996年10月17日本发明涉及一种用于限定多孔基底上的层的区域（4）的方法，包括压缩一定体积的基底以产生压缩区域（8），所述压缩区域（8）定义或与 衬底或层的边缘（7）限定了该区域的边界，并且基本上防止了材料通过其或穿过其表面的传送。 本发明还涉及一种电化学感测装置，包括：多孔基材; 以及在所述基板的一侧上的电极（1） 其中所述衬底的区域被压缩到对所述衬底内的电解质迁移的阻挡的程度，所述压缩区限定或者与所述衬底或所述电极的边缘组合以限定所述预定区域的电极上的区域。
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公开(公告)号：US5942102A
公开(公告)日：1999-08-24
申请号：US852804
申请日：1997-05-07
IPC分类号： G01N27/28 , C12Q1/00 , C12Q1/54 , G01N20060101 , G01N27/30 , G01N27/327 , G01N27/403 , G01N27/416 , G01N27/42 , G01N27/49 , G01N33/487 , G01N27/26
CPC分类号： C12Q1/006 , C12Q1/004 , G01N27/3272
摘要： A method for determining the concentration of a reduced or oxidized form of a redox species in an electrochemical cell (FIG. 10) of the kind comprising a working electrode (2) and a counter electrode (16) spaced from the working electrode such that reaction products from the counter electrode arrive at the working electrode, the method comprising the steps (FIG. 5) of applying (21) an electric potential between the electrodes, such that the electro-oxidation of the redox species is diffusion controlled, determining the current as a function of time, estimating the magnitude of the steady state current (23), reversing the potential, again determining current as a function of time and estimating the reverse potential steady state (25).
摘要翻译： 一种用于确定电化学电池（图10）中还原或氧化形式的还原或氧化形式的浓度的方法，其包括与工作电极间隔开的工作电极（2）和对电极（16），使得反应 来自对电极的产品到达工作电极，该方法包括在电极之间施加（21）电位的步骤（图5），使得氧化还原物质的电氧化被扩散控制，确定电流 作为时间的函数，估计稳态电流（23）的大小，反转电位，再次确定电流作为时间的函数，并估计反向电位稳态（25）。
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公开(公告)号：US08597480B2
公开(公告)日：2013-12-03
申请号：US13357318
申请日：2012-01-24
IPC分类号： G01N27/403 , G01N27/327
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： Devices and methods are provided for determining the concentration of a reduced form of a redox species. For example, a device can include a working electrode and a counter electrode spaced by a predetermined distance so that reaction produces from the counter electrode arrive at the working electrode. An electric potential difference can be applied between the electrodes, and the potential of the working electrode can be selected such that the rate of electro-oxidation of the reduced form of the species is diffusion controlled. Current as a function of time can be determined, the magnitude of the steady state current can be estimated, and a value indicative of the diffusion coefficient and/or of the concentration of the reduced form of the species can be obtained from the change in current with time and the magnitude of the steady state current. Other embodiments of apparatuses, devices, and methods are also provided.
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