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    COMPOSITIONS FOR TREATING MICROBIAL INFECTIONS
    7.
    发明申请
    COMPOSITIONS FOR TREATING MICROBIAL INFECTIONS 审中-公开
    用于治疗微生物感染的组合物

    公开(公告)号：US20150174137A1

    公开(公告)日：2015-06-25

    申请号：US14632547

    申请日：2015-02-26

    申请人： ALCON RESEARCH, LTD.

    发明人： Malay Ghosh ,  Masood A. Chowhan

    IPC分类号： A61K31/5383 ,  A61K47/02 ,  A61K45/06

    CPC分类号： A61K31/5383 ,  A61K9/0048 ,  A61K33/06 ,  A61K33/30 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to methods for treating a microbial infection comprising treating the infected tissue with a composition comprising a quinolone such as finafloxacin and a divalent cation such as magnesium. The present invention also relates to antimicrobial compositions comprising a quinolone such as finafloxacin and a divalent cation such as magnesium.

    摘要翻译： 本发明涉及用于治疗微生物感染的方法，包括用包含喹诺酮如氟尼沙星和二价阳离子如镁的组合物处理感染组织。 本发明还涉及包含喹诺酮如氟咪沙星和二价阳离子如镁的抗微生物组合物。

    Phospholipid Compositions for Contact Lens Care and Preservation of Pharmaceutical Compositions
    10.
    发明申请
    Phospholipid Compositions for Contact Lens Care and Preservation of Pharmaceutical Compositions 审中-公开
    用于隐形眼镜护理和药物组合物保存的磷脂组合物

    公开(公告)号：US20150209466A1

    公开(公告)日：2015-07-30

    申请号：US14626443

    申请日：2015-02-19

    申请人： ALCON RESEARCH, LTD.

    发明人： Malay Ghosh ,  Masood A. Chowhan ,  L. Wayne Schneider

    IPC分类号： A61L12/14 ,  A01N57/12

    CPC分类号： A61L12/143 ,  A01N57/12 ,  A61L2/18

    摘要： The use of certain synthetic phospholipids to preserve pharmaceutical compositions from microbial contamination is described. The synthetic phospholipids have unique molecular arrangements wherein a phosphate group is linked to a quaternary ammonium functionality via a substituted-propenyl group, and the quaternary ammonium functionality is further linked to at least one long hydrocarbon chain. Such molecular arrangements are what make the phospholipids of formula (I) highly water soluble, e.g., the length of the hydrocarbon chain assists to maintain solubility and efficacy of the molecules for the uses described herein. The synthetic phospholipids described herein have been found to be particularly useful as antimicrobial preservatives for ophthalmic, otic and nasal pharmaceutical compositions, especially ophthalmic compositions. These compounds may also be utilized to disinfect contact lenses. The invention is based in-part upon a finding that the antimicrobial activity of the synthetic phospholipids is affected by the ionic strength of the compositions in which the compounds are contained. The provision of compounds having limited ionic strengths is therefore preferred.

    摘要翻译： 描述了使用某些合成磷脂来保护药物组合物免受微生物污染。 合成磷脂具有独特的分子结构，其中磷酸基通过取代丙烯基与季铵官能团连接，并且季铵官能团进一步连接至至少一个长烃链。 这样的分子结构使得式（I）的磷脂具有高度水溶性，例如，烃链的长度有助于保持分子用于本文所述用途的溶解度和功效。 已经发现本文所述的合成磷脂特别可用作眼用，耳用和鼻用药物组合物，特别是眼用组合物的抗微生物防腐剂。 这些化合物也可用于消毒隐形眼镜。 本发明部分地基于这样的发现，即合成磷脂的抗微生物活性受包含化合物的组合物的离子强度的影响。 因此优选提供具有有限离子强度的化合物。