公开(公告)号：US07285659B2

公开(公告)日：2007-10-23

申请号：US10485335

申请日：2002-07-29

申请人： Aldo Banfi ,  Bruno Dall'Oro ,  Marco Frigerio ,  Alfredo Mancini

发明人： Aldo Banfi ,  Bruno Dall'Oro ,  Marco Frigerio ,  Alfredo Mancini

IPC分类号： C07H19/56 ,  C07H5/04

CPC分类号： C07H19/056 ,  C07H1/00

摘要： A process for the preparation of ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid. Said process comprises: a) the reaction of a triazole of the formula  with a protected ribofuranose of the formula b) the removal of the Pg groups and, optionally, the conversion into a carboxyamide group of the R2 group of the compound obtained of the formula  DD/mac—01.07.02.

摘要翻译： 描述了以工业规模制备利巴韦林的方法，其包括在路易斯酸存在下3-取代三唑的糖基化反应。 所述方法包括：a）将下式的三唑与式b的保护的呋喃核糖反应：除去Pg基团，以及任选地转化为R 2的羧酰胺基团， 所述化合物由式DD / mac-01.07.02得到。

公开(公告)号：US07285660B2

公开(公告)日：2007-10-23

申请号：US10485436

申请日：2002-07-25

申请人： Aldo Banfi ,  Bruno Dall'Oro ,  Marco Frigerio ,  Alfredo Mancini

发明人： Aldo Banfi ,  Bruno Dall'Oro ,  Marco Frigerio ,  Alfredo Mancini

IPC分类号： C07H19/56 ,  C07H5/04

CPC分类号： C07H19/056 ,  C07H1/00

摘要： A process for the preparation of L-ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid. Said process comprises: a) the reaction of a triazole of the formula with a protected ribofuranose of the formula (II) b) the removal of the Pg groups and, optionally, the conversion into a carboxyamide group of the R2 group of the compound obtained of the formula (III)

摘要翻译：

公开(公告)号：US07091382B2

公开(公告)日：2006-08-15

申请号：US10841403

申请日：2004-05-07

申请人： Aldo Banfi ,  Alfredo Mancini

发明人： Aldo Banfi ,  Alfredo Mancini

IPC分类号： C07C211/00

CPC分类号： C07C221/00 ,  C07C223/02

摘要： A process is disclosed for manufacturing N-methyl-N-phenylaminoacrolein of formula (I) which comprises reacting N-methylformanilide and an alkyl vinyl ether of formula (III) wherein R is a C3–C4 alkyl, said process being characterized in that the reaction between N-methylformanilide and said alkyl vinyl ether of formula (III) is carried out in the presence of phosgene, diphosgene or triphosgene in a solvent selected from dioxane, acetonitrile and/or chlorobenzene.

摘要翻译： 公开了制备式（I）的N-甲基-N-苯基氨基丙烯醛的方法，其包括使N-甲基甲酰苯胺和式（III）的烷基乙烯基醚反应，其中R是C 3 -C 所述方法的特征在于N-甲基甲酰苯胺和式（III）的所述烷基乙烯基醚之间的反应在光气，双光气或三光气存在下，在选自二恶烷， 乙腈和/或氯苯。

公开(公告)号：US20090139162A1

公开(公告)日：2009-06-04

申请号：US11998681

申请日：2007-11-30

申请人： Alfredo Mancini

发明人： Alfredo Mancini

IPC分类号： E06B7/02 ,  G08B17/10

CPC分类号： E06B7/02 ,  A62B13/00

摘要： A bedroom window that detects predetermined levels of carbon monoxide and automatically open by itself to save the occupants lives without any external electrical supply, replaceable alkaline batteries or any human action; this lifesaver window is self-contained, pre-assembled, solar-powered, environmentally friendly and able to open the window sash by itself to allow the CO to escape, to reduce CO concentration, to let the outside clean air to enter the room, to sound it's alarm, and to trigger the Fire & Police Private Central Station Alarm; it can be installed as new or as a replacement window in homes, hotels, hospitals, dormers or wherever humans or animals live; can be manufactured in different sizes and styles to accommodate any architectural design and furthermore it installation requires the same skills & tools needed to install a regular window without the need of other trades.

摘要翻译： 一个卧室窗口，可检测预定水平的一氧化碳，并自动打开，以免任何外部电源，可更换的碱性电池或任何人的行为，从而挽救居住者的生命; 这个救生窗是独立的，预组装的，太阳能的，环保的，并且能够自己打开窗框，以允许CO逃逸，以减少CO浓度，使外部清洁空气进入房间， 听起来闹闹，触发消防警察私人中央车站报警; 它可以安装在家庭，酒店，医院，宿舍或人类或动物居住地方的新的或作为替代窗口; 可以以不同的尺寸和风格制造以适应任何建筑设计，此外，安装需要与安装常规窗口相同的技能和工具，而不需要其他行业。

公开(公告)号：US20120322996A1

公开(公告)日：2012-12-20

申请号：US12160629

申请日：2007-02-26

申请人： Gianluca Di Lernia ,  Alfredo Mancini ,  Franco Mancini ,  Maurizio Serra ,  Domenico Vergani

发明人： Gianluca Di Lernia ,  Alfredo Mancini ,  Franco Mancini ,  Maurizio Serra ,  Domenico Vergani

IPC分类号： C07H1/00

CPC分类号： C07D405/04

摘要： A novel method for the preparation of stavudine polymorphic form I and form II is described. 5′-acetate-2′,3′-diacetyl-5-methyluridine is reacted with catalytic amounts of sodium methoxide in a C1-C4 alcoholic solvent, resulting in crude stavudine form II. Crude stavudine form II can be converted into polymorphic stavudine form I by slurry at reflux in isopropanol, without isolating or purifying the crude stavudine form II.

摘要翻译： 描述了一种制备司他夫定多形态I和II型的新方法。 5'-乙酸酯-2'，3'-二乙酰基-5-甲基尿苷与C1-C4醇溶剂中的催化量的甲醇钠反应，得到粗制的司他夫定II型。 粗制的司他夫定II型可以通过在异丙醇中回流的浆液转化成I型多形态，而不分离或纯化粗制的司他夫定II型。

公开(公告)号：USRE45804E1

公开(公告)日：2015-11-17

申请号：US13998919

申请日：2013-12-23

申请人： Alfredo Mancini

发明人： Alfredo Mancini

IPC分类号： G08B17/10 ,  E06B7/02

CPC分类号： E06B7/02 ,  A62B13/00

摘要： A window with built-in devices that senses carbon monoxide; powered only by the exterior daylight; that automatically opens by itself and sounds an alarm when a dangerous level of carbon monoxide is sensed to release the accumulated carbon monoxide and let the clean air with fresh oxygen enter the contaminated area to prevent or minimize poisoning and/or death of humans & animals without the need of any human physical action; the provided contacts can be connected to a private alarm station to alert the Fire & Police Departments to provide immediate assistance to the endangered humans & animals and protect the opened residence.

摘要翻译： 带有内置设备的窗口，可感测一氧化碳; 仅由外部日光灯驱动; 当自动打开时，当感测到危险程度的一氧化碳释放累积的一氧化碳并使新鲜氧气的清洁空气进入污染区域，以防止或最小化人类和动物的中毒和/或死亡，而没有 任何人的身体行为的需要; 所提供的联系人可以连接到私人警报站，以提醒消防局和警察署立即援助濒危人类和动物，并保护开放的住所。

公开(公告)号：US08120501B2

公开(公告)日：2012-02-21

申请号：US11998681

申请日：2007-11-30

申请人： Alfredo Mancini

发明人： Alfredo Mancini

IPC分类号： G08B17/10

CPC分类号： E06B7/02 ,  A62B13/00

摘要： A window with built-in devices that senses carbon monoxide; powered only by the exterior daylight; that automatically opens by itself and sounds an alarm when a dangerous level of carbon monoxide is sensed to release the accumulated carbon monoxide and let the clean air with fresh oxygen enter the contaminated area to prevent or minimize poisoning and/or death of humans & animals without the need of any human physical action; the provided contacts can be connected to a private alarm station to alert the Fire & Police Departments to provide immediate assistance to the endangered humans & animals and protect the opened residence.

摘要翻译： 带有内置设备的窗口，可感测一氧化碳; 仅由外部日光灯驱动; 当自动打开时，当感测到危险程度的一氧化碳释放累积的一氧化碳并使新鲜氧气的清洁空气进入污染区域以防止或最小化人类和动物的中毒和/或死亡而没有 任何人的身体行为的需要; 所提供的联系人可以连接到私人报警站，以提醒消防局和警察署立即向濒危人类和动物提供援助，并保护开放的住所。